DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and LINGO4

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001004432.1	Gene:	LINGO4 / 339398	HGNCID:	31814	Length:	593	Species:	Homo sapiens

Alignment Length:	428	Identity:	129/428 - (30%)
Similarity:	187/428 - (43%)	Gaps:	44/428 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSSM-Q 92
            |.|..||...| .:||..|:|......|.||...|:.:|..|....:.|.:..|:|..:...| .
Human    18 LFLLLLPGGSG-GSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLS 81

  Fly    93 FYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAE 157
            ..:.|..||||:|.:.|:...:|.....|..|.|..|::..:....|.|||.:::|:||.|.|..
Human    82 RLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVL 146

  Fly   158 LEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELY 222
            .....|..:..|.:|.:|.|.:..:.|.|..||..|..|.|:...|:|||| |....|.:|..|.
Human   147 FLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPG-LALARLPALVALR 210

  Fly   223 LGTNSFMTIPGGAFQDLKGLTRLDLR-GAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQR 286
            |.......:|.||.:.|..|..|::. ...|..:...:|.|| :|..|.::...|.::|..|...
Human   211 LRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-NLSSLAITRCNLSSVPFQALYH 274

  Fly   287 LGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLN 351
            |..|..|::.||....|.:...|.|..|:.|.|:|| .|..:.:.||.|.|....|:::.
Human   275 LSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGA-CLTSIAAHAFHGLTAFHLLDVAD----- 333

  Fly   352 ELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWAD-LQTLDLSENPFECDCRLLWLRHLLVSRNA 415
                                |.|.:|:|...|..| |.||.||.||..||||||||  |.:.|:.
Human   334 --------------------NALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWL--LRLRRHL 376

  Fly   416 SGQYAPVICAYP-----TALRD----LPLAHL-AEPLL 443
            ....:|..||.|     .:|::    ||..|. .:|.|
Human   377 DFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPAL 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/21 (19%)
		LRR_8	96..155	CDD:290566	20/58 (34%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_8	143..201	CDD:290566	18/57 (32%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	73/251 (29%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..217	CDD:275380	10/23 (43%)
		LRR_8	217..276	CDD:290566	15/59 (25%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	6/23 (26%)
		LRR_8	265..321	CDD:290566	16/55 (29%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		LRR_8	312..374	CDD:290566	12/61 (20%)
		leucine-rich repeat	314..335	CDD:275380	8/20 (40%)
		leucine-rich repeat	339..363	CDD:275380	1/23 (4%)
		LRRCT	395..445	CDD:214507	22/59 (37%)
LINGO4	NP_001004432.1	LRRNT	31..64	CDD:214470	10/32 (31%)
		leucine-rich repeat	62..85	CDD:275380	4/22 (18%)
		LRR_8	65..120	CDD:290566	16/54 (30%)
		leucine-rich repeat	86..109	CDD:275380	8/22 (36%)
		LRR_RI	87..320	CDD:238064	71/235 (30%)
		LRR_8	109..168	CDD:290566	18/58 (31%)
		leucine-rich repeat	110..133	CDD:275380	7/22 (32%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		LRR_8	157..212	CDD:290566	20/55 (36%)
		leucine-rich repeat	158..181	CDD:275380	8/22 (36%)
		leucine-rich repeat	182..205	CDD:275380	10/23 (43%)
		leucine-rich repeat	206..229	CDD:275380	7/22 (32%)
		leucine-rich repeat	230..277	CDD:275380	12/47 (26%)
		LRR_8	253..309	CDD:290566	16/55 (29%)
		leucine-rich repeat	278..301	CDD:275380	7/22 (32%)
		LRR_8	301..360	CDD:290566	23/84 (27%)
		leucine-rich repeat	302..325	CDD:275380	9/23 (39%)
		leucine-rich repeat	326..344	CDD:275380	5/42 (12%)
		leucine-rich repeat	350..362	CDD:275378	7/11 (64%)
		IG_like	420..501	CDD:214653
		Ig	431..501	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910