Protein Alignment caps and LINGO4

DIOPT Version :10

• Sequence 1: NP_001303391.1
• Gene: caps / 39493
• FlyBaseID: FBgn0023095
• Length: 811
• Species: Drosophila melanogaster
• Sequence 2: NP_001004432.1
• Gene: LINGO4 / 339398
• HGNCID: 31814
• Length: 593
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 129/428 - (30%)
• Similarity: 187/428 - (43%)
• Gaps: 44/428 - (10%)

  Fly    29 LVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSSM-Q 92
            |.|..||...| .:||..|:|......|.||...|:.:|..|....:.|.:..|:|..:...| .
Human    18 LFLLLLPGGSG-GSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLS 81

  Fly    93 FYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAE 157
            ..:.|..||||:|.:.|:...:|.....|..|.|..|::..:....|.|||.:::|:||.|.|..
Human    82 RLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVL 146

  Fly   158 LEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELY 222
            .....|..:..|.:|.:|.|.:..:.|.|..||..|..|.|:...|:|||| |....|.:|..|.
Human   147 FLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPG-LALARLPALVALR 210

  Fly   223 LGTNSFMTIPGGAFQDLKGLTRLDLR-GAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQR 286
            |.......:|.||.:.|..|..|::. ...|..:...:|.|| :|..|.::...|.::|..|...
Human   211 LRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-NLSSLAITRCNLSSVPFQALYH 274

  Fly   287 LGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLN 351
            |..|..|::.||....|.:...|.|..|:.|.|:|| .|..:.:.||.|.|....|:::.
Human   275 LSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGA-CLTSIAAHAFHGLTAFHLLDVAD----- 333

  Fly   352 ELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWAD-LQTLDLSENPFECDCRLLWLRHLLVSRNA 415
                                |.|.:|:|...|..| |.||.||.||..||||||||  |.:.|:.
Human   334 --------------------NALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWL--LRLRRHL 376

  Fly   416 SGQYAPVICAYP-----TALRD----LPLAHL-AEPLL 443
            ....:|..||.|     .:|::    ||..|. .:|.|
Human   377 DFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPAL 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/21 (19%)
		LRR_8	96..155	CDD:404697	20/58 (34%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR	135..>398	CDD:443914	78/264 (30%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..217	CDD:275380	10/23 (43%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	6/23 (26%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..335	CDD:275380	8/20 (40%)
		leucine-rich repeat	339..363	CDD:275380	1/23 (4%)
		LRRCT	395..445	CDD:214507	22/59 (37%)
LINGO4	NP_001004432.1	LRRNT	31..64	CDD:214470	10/32 (31%)
		leucine-rich repeat	62..85	CDD:275380	4/22 (18%)
		LRR	<63..342	CDD:443914	84/306 (27%)
		leucine-rich repeat	86..109	CDD:275380	8/22 (36%)
		leucine-rich repeat	110..133	CDD:275380	7/22 (32%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		leucine-rich repeat	158..181	CDD:275380	8/22 (36%)
		leucine-rich repeat	182..205	CDD:275380	10/23 (43%)
		leucine-rich repeat	206..229	CDD:275380	7/22 (32%)
		leucine-rich repeat	230..277	CDD:275380	12/47 (26%)
		leucine-rich repeat	278..301	CDD:275380	7/22 (32%)
		leucine-rich repeat	302..325	CDD:275380	9/23 (39%)
		leucine-rich repeat	326..344	CDD:275380	5/42 (12%)
		leucine-rich repeat	350..362	CDD:275378	7/11 (64%)
		IG_like	420..501	CDD:214653
		Ig strand B	431..435	CDD:409353
		Ig strand C	444..448	CDD:409353
		Ig strand E	467..471	CDD:409353
		Ig strand F	481..486	CDD:409353
		Ig strand G	494..497	CDD:409353