DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and Lrfn2

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001034788.1	Gene:	Lrfn2 / 316205	RGDID:	1311831	Length:	788	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	161/719 - (22%)
Similarity:	252/719 - (35%)	Gaps:	242/719 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 LNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTF 212
            |.|.||.|..:..:.|:.|..|.:|.|.:|.||||.|.:...|::||.|:||.|.|.:: ||.|.
  Rat    57 LRLGGNFIIHIGRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSL-GEDTL 120

  Fly   213 QALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLP 277
            :.|.:|..|.:..|....|...||:|.                       |::|..||||.|.|.
  Rat   121 RGLVNLQHLIVNNNQLGGIADDAFEDF-----------------------LLTLEDLDLSYNNLH 162

  Fly   278 AIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHL 342
            .:|..:.:|:..|.||::..|..:.|:.|.|:.|::|..|:|| :.||::
  Rat   163 GLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLT-SNRLQK--------------- 211

  Fly   343 NLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFECDCRLLWLR 407
                              ||  ...:...:|.|.|.  ..|:|...:.....||..|:|.|||||
  Rat   212 ------------------LP--PDPIFARSQASLLT--ATPFAPPLSFSFGGNPLHCNCELLWLR 254

  Fly   408 HL---------------------------------LVSRNA------SGQYAPVICAYPTALRD- 432
            .|                                 |::::.      .||.|.:.|   .|:.|
  Rat   255 RLERDDDLETCGSPGGLKGRYFWHIREEEFVCEPPLITQHTHKLLVLEGQAATLKC---KAIGDP 316

  Fly   433 LPLAHLAEP---LLGCAHGAASKQAII--GILVVACAALITTLA-LVLYTCRHRIREMLKGHSAL 491
            .||.|...|   |:    |.:|:.|:.  |.|.:    ||||.. ...:||        ...:|.
  Rat   317 SPLIHWVAPDDRLV----GNSSRTAVYDNGTLDI----LITTSQDSGPFTC--------IAANAA 365

  Fly   492 GRKEREYQKTFSDEEYMSRPPPGGGGVHPAAGGYPYIAGNSRMIPVTELXLEAPPPPQL------ 550
            |......:.:.....::|.                   ..|||         |||..:|
  Rat   366 GEATATVEVSIVQLPHLSN-------------------STSRM---------APPKSRLSDITGS 402

  Fly   551 --RGRGGGGGASTASGAVQQLQVPSAVDQASNSFAQLSHIHYMTNNGQQQQAQQQQSTSKMHHSQ 613
              ..|||||     |||.:.   |.:..:.:...:.::....:......:.|.:    .||:..|
  Rat   403 SKTSRGGGG-----SGAGEP---PKSTPERAVLVSDVTTTSALVKWSVSKSAPR----VKMYQLQ 455

  Fly   614 QDMRLLACNGGKPLNATSLPRHRPPVVQESTLSHYSQPLA-------NGIRLTQDHF-------- 663
            .:     |:..:.|....:|......|..:.:|.....|.       ....||..:.
  Rat   456 YN-----CSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFT 515

  Fly   664 --NHNQNQS-HNQHYGG----------------------VYAKPC--DAMSEPG----------Y 691
              ::.|.|| |:|..||                      |..|.|  ||   ||          |
  Rat   516 KADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVILMVRYKVCNHDA---PGKMAAATVSNVY 577

  Fly   692 IHNNSHYSLPLDHDLPPSPTPTPPPPALPLRNGVGMALIHGNTTGRRSFNNNNNVSTLSNNNHHG 756
            ...|.....||. .:|....|..||..: :||    .|:..:|:..|:.::::: |:|.:....|
  Rat   578 SQTNGAQPPPLG-GMPVGQLPQAPPKVV-VRN----ELMDFSTSLARACDSSSS-SSLGSGEAAG 635

  Fly   757 IGGG 760
            :..|
  Rat   636 LSRG 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380
		LRR_8	96..155	CDD:290566	4/6 (67%)
		leucine-rich repeat	97..120	CDD:275380
		leucine-rich repeat	121..144	CDD:275380
		LRR_8	143..201	CDD:290566	22/52 (42%)
		leucine-rich repeat	145..168	CDD:275380	7/19 (37%)
		LRR_RI	147..397	CDD:238064	67/248 (27%)
		leucine-rich repeat	169..192	CDD:275380	10/22 (45%)
		leucine-rich repeat	193..217	CDD:275380	11/23 (48%)
		LRR_8	217..276	CDD:290566	14/58 (24%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	1/22 (5%)
		LRR_8	265..321	CDD:290566	20/55 (36%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		LRR_8	312..374	CDD:290566	8/61 (13%)
		leucine-rich repeat	314..335	CDD:275380	6/20 (30%)
		leucine-rich repeat	339..363	CDD:275380	1/23 (4%)
		LRRCT	395..445	CDD:214507	22/92 (24%)
Lrfn2	NP_001034788.1	LRR_RI	27..>209	CDD:238064	57/176 (32%)
		LRR 1	53..74		6/16 (38%)
		leucine-rich repeat	54..77	CDD:275380	7/19 (37%)
		LRR_8	76..136	CDD:290566	24/60 (40%)
		LRR 2	77..98		9/20 (45%)
		leucine-rich repeat	78..101	CDD:275380	10/22 (45%)
		LRR 3	101..122		10/21 (48%)
		leucine-rich repeat	102..125	CDD:275380	11/23 (48%)
		LRR_8	125..185	CDD:290566	21/82 (26%)
		LRR 4	125..146		6/20 (30%)
		leucine-rich repeat	126..150	CDD:275380	8/46 (17%)
		LRR 5	150..171		8/20 (40%)
		leucine-rich repeat	151..174	CDD:275380	9/22 (41%)
		LRR_8	174..>215	CDD:290566	16/76 (21%)
		LRR 6	174..195		7/20 (35%)
		leucine-rich repeat	175..198	CDD:275380	8/22 (36%)
		LRR 7	198..219		8/56 (14%)
		LRRCT	242..286	CDD:214507	10/43 (23%)
		IG_like	298..376	CDD:214653	24/96 (25%)
		Ig	303..376	CDD:299845	24/91 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..423		17/75 (23%)
		fn3	428..493	CDD:278470	10/73 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..655		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..707
		PDZ-binding	785..788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000