DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and Lingo1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001094192.1	Gene:	Lingo1 / 315691	RGDID:	1308668	Length:	620	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	134/521 - (25%)
Similarity:	194/521 - (37%)	Gaps:	127/521 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LCLVLATLPVALGLA-NCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSS 90
            |.|||.:  |..|.| .||..|||......|.|.......:|..: |...||
  Rat    27 LLLVLGS--VLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGI-PTETRL------------- 75

  Fly    91 MQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLI 155
                     |||..|.:.|:.:..||....|:||.|:.|.:..|....|..|..:..|.||.|.:
  Rat    76 ---------LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL 131

  Fly   156 AELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAE 220
            ..:....|:.:..|.:|::.:|:|..:..:....|.||:.|.:.||.|..: ....|..|:||.:
  Rat   132 KLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYI-SHRAFSGLNSLEQ 195

  Fly   221 LYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLS-----DNRLP--- 277
            |.|...:..:||..|...|.||..|.||...::.|...:.|.|..|:.|::|     |...|
  Rat   196 LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCL 260

  Fly   278 ----------------AIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLR 326
                            |:|..|.:.|..|..||:..|....|.......|..|:.::|.|.| |.
  Rat   261 YGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQ-LA 324

  Fly   327 RVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLV-PWADLQTL 390
            .||..||.|...|..||:|                         .|||::|:|... ...:|:||
  Rat   325 VVEPYAFRGLNYLRVLNVS-------------------------GNQLTTLEESAFHSVGNLETL 364

  Fly   391 DLSENPFECDCRLLWLRHLLVSRNASGQYAPVICAYPTALRDLPLAHLAEPLLGCAHGAASKQAI 455
            .|..||..|||||||:.......|.:.|..  .||.|..::........:.||.
  Rat   365 ILDSNPLACDCRLLWVFRRRWRLNFNRQQP--TCATPEFVQGKEFKDFPDVLLP----------- 416

  Fly   456 IGILVVACAALITTLALVLYTCRHRIREMLKGHSALGRKEREYQKTFSDE----EYMSR----PP 512
                             ..:|||       :.|.    ::|:.|:.|.||    :::.|    ||
  Rat   417 -----------------NYFTCR-------RAHI----RDRKAQQVFVDEGHTVQFVCRADGDPP 453

  Fly   513 P 513
            |
  Rat   454 P 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	2/20 (10%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_8	143..201	CDD:290566	13/57 (23%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_RI	147..397	CDD:238064	73/274 (27%)
		leucine-rich repeat	169..192	CDD:275380	5/22 (23%)
		leucine-rich repeat	193..217	CDD:275380	7/23 (30%)
		LRR_8	217..276	CDD:290566	20/63 (32%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	7/22 (32%)
		LRR_8	265..321	CDD:290566	17/79 (22%)
		leucine-rich repeat	266..289	CDD:275380	9/46 (20%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	15/61 (25%)
		leucine-rich repeat	314..335	CDD:275380	9/20 (45%)
		leucine-rich repeat	339..363	CDD:275380	4/23 (17%)
		LRRCT	395..445	CDD:214507	16/49 (33%)
Lingo1	NP_001094192.1	LRRNT	41..75	CDD:214470	9/34 (26%)
		LRR	<66..371	CDD:227223	92/354 (26%)
		leucine-rich repeat	73..96	CDD:275380	9/44 (20%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		LRR_8	120..179	CDD:404697	15/58 (26%)
		leucine-rich repeat	121..144	CDD:275380	5/22 (23%)
		leucine-rich repeat	145..192	CDD:275380	13/47 (28%)
		leucine-rich repeat	193..216	CDD:275380	7/22 (32%)
		leucine-rich repeat	217..264	CDD:275380	12/46 (26%)
		leucine-rich repeat	265..288	CDD:275380	4/22 (18%)
		leucine-rich repeat	289..312	CDD:275380	6/22 (27%)
		leucine-rich repeat	313..336	CDD:275380	10/23 (43%)
		leucine-rich repeat	337..357	CDD:275380	9/44 (20%)
		PCC	341..>421	CDD:188093	27/134 (20%)
		IgI_Lingo-1	423..514	CDD:409561	10/36 (28%)
		Ig strand B	442..446	CDD:409561	0/3 (0%)
		Ig strand C	455..459	CDD:409561	134/521 (26%)
		Ig strand E	480..484	CDD:409561
		Ig strand F	494..499	CDD:409561
		Ig strand G	507..510	CDD:409561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I11953
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8997
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910