DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and Lrrc4c

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001101223.1	Gene:	Lrrc4c / 311236	RGDID:	1311013	Length:	640	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	138/532 - (25%)
Similarity:	194/532 - (36%)	Gaps:	173/532 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MSLAPH---LGQAFSLCLCLCLCLVLATLP--VALGLA---NCPNGCECDDDTLMVNCGEGTLDV 65
            |:|.|.   :|..|:..|...|.:||..|.  |..||.   .||:.|.|.:....|.|
  Rat     5 MTLHPQQIMIGPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVIC------- 62

  Fly    66 LPIALNPAIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNK 130
                        |.||                         :..:|:
  Rat    63 ------------VRKN-------------------------LREVPD------------------ 72

  Fly   131 IGQVSNKTFLGLST-ISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLR 194
                      |:|| ..:|||..|.|..::..:|..:..|..|.|.:|.|..|:..|.:||.||.
  Rat    73 ----------GISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLN 127

  Fly   195 VLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAG----LHNI 255
            .|.|.||.|||:|.. .|..|..|.||:|..|...:||..||..:..|.||||   |    |..|
  Rat   128 TLELFDNRLTTIPNG-AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDL---GELKRLSYI 188

  Fly   256 SGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELT 320
            |..|.:||.:||:|:|:...|..||.  ...|.:|::|::..|....|..|:|.||..|:.|.:.
  Rat   189 SEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMI 251

  Fly   321 GAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWA 385
            .:| ::.:|..||....:|..:||:.|.         |..|||               :...|..
  Rat   252 QSQ-IQVIERNAFDNLQSLVEINLAHNN---------LTLLPH---------------DLFTPLH 291

  Fly   386 DLQTLDLSENPFECDCRLLWL----RHLLVSR-----------NASGQ------------YAPVI 423
            .|:.:.|..||:.|:|.:|||    |.:..|.           |..|:            |||||
  Rat   292 HLERIHLHHNPWNCNCDILWLSWWIRDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVI 356

  Fly   424 CAYPTALRDLPLAHLAEPLLGC-------------------AHGAASKQAIIGILVVACAAL--- 466
            ...|.   ||.:.......|.|                   .|||..    :.|.|::...|
  Rat   357 VEPPA---DLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYK----VRIAVLSDGTLNFT 414

  Fly   467 -ITTLALVLYTC 477
             :|.....:|||
  Rat   415 NVTVQDTGMYTC 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	3/20 (15%)
		LRR_8	96..155	CDD:290566	8/59 (14%)
		leucine-rich repeat	97..120	CDD:275380	1/22 (5%)
		leucine-rich repeat	121..144	CDD:275380	1/22 (5%)
		LRR_8	143..201	CDD:290566	21/58 (36%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	82/253 (32%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		leucine-rich repeat	193..217	CDD:275380	11/23 (48%)
		LRR_8	217..276	CDD:290566	25/62 (40%)
		leucine-rich repeat	218..241	CDD:275380	9/22 (41%)
		leucine-rich repeat	242..265	CDD:275380	12/26 (46%)
		LRR_8	265..321	CDD:290566	18/55 (33%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		LRR_8	312..374	CDD:290566	14/61 (23%)
		leucine-rich repeat	314..335	CDD:275380	6/20 (30%)
		leucine-rich repeat	339..363	CDD:275380	6/23 (26%)
		LRRCT	395..445	CDD:214507	20/76 (26%)
Lrrc4c	NP_001101223.1	LRRNT	47..80	CDD:214470	13/104 (13%)
		PPP1R42	65..235	CDD:411060	65/228 (29%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		leucine-rich repeat	126..149	CDD:275380	11/23 (48%)
		leucine-rich repeat	150..173	CDD:275380	9/22 (41%)
		leucine-rich repeat	174..198	CDD:275380	12/26 (46%)
		leucine-rich repeat	199..220	CDD:275380	8/22 (36%)
		LRR_8	220..279	CDD:404697	18/68 (26%)
		leucine-rich repeat	221..244	CDD:275380	8/22 (36%)
		leucine-rich repeat	245..268	CDD:275380	6/23 (26%)
		LRR_8	267..>301	CDD:404697	11/57 (19%)
		leucine-rich repeat	269..290	CDD:275380	8/44 (18%)
		LRRCT	301..>339	CDD:214507	10/37 (27%)
		IG	360..443	CDD:214652	15/74 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910