DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and Lrrn2

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001170839.1	Gene:	Lrrn2 / 289020	RGDID:	1305482	Length:	750	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	151/572 - (26%)
Similarity:	239/572 - (41%)	Gaps:	110/572 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LPVALGLANCPNGCECD-----------DDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTI 87
            :||......||..|.|.           .:...|:|.:..|..:|..|....|.|::::|.:..|
  Rat    20 VPVVPWRVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPGLPAGTQTLLLQSNSISRI 84

  Fly    88 D-SSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLR 151
            : :.:.:.|.||.||||.|......:..|....:|..|||:.|::.::.:.:|.||:
  Rat    85 EQTELGYLANLTELDLSQNSFSDARDCDFQALPQLLSLHLEENQLSRLEDHSFAGLT-------- 141

  Fly   152 GNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALH 216
                            :|.||.|..|::..|.|.|.:||.||..|:|:.|.|.|:... .|:.|.
  Rat   142 ----------------RLQELYLNHNQLCRISPRAFEGLGNLLRLHLNSNLLRTIDSR-WFEMLP 189

  Fly   217 SLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPT 281
            :|..|.:|.|....|....|:.|..|..|.|.|..|..||..||:||.||..|...||:|..:|.
  Rat   190 NLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMSLREISDYALEGLQSLESLSFYDNQLAQVPK 254

  Fly   282 AAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSS 346
            .|.:::..|:.|::.:|..:.:..|.|:.:..|:.|.|...:.|..::..|......|..|::::
  Rat   255 RALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITN 319

  Fly   347 NKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLV-PWADLQTLDLSENPFECDCRLLWLRHLL 410
            |.:|:.:...|...||.:.|::|..|.||:|.:..| ...:||.:.|..||..|||.:.|
  Rat   320 NPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRW----- 379

  Fly   411 VSRNASGQYA------PVICAYPTAL-----RDLPLAHLAE---PLLGCAHGAASKQAIIG-ILV 460
              .||:|.:.      ..:||.|..|     |::|...:.:   ||:......:|.|...| .||
  Rat   380 --ANATGTHVRFIEPQSTLCAEPPDLQRRPVREVPFREMTDHCLPLISPRSFPSSLQVASGESLV 442

  Fly   461 VACAAL---------ITTLALVLYTCRHRIREMLKGHSALGRKER-------EYQKTFSDEEYMS 509
            :.|.||         :|...:.|...|.            |||.|       |.::..::|
  Rat   443 LHCRALAEPEPEIYWVTPAGVRLTPARS------------GRKYRVFPEGTLELRRVTAEE---- 491

  Fly   510 RPPPGGGGVHPAAGGYPYIAGN---SRMIPVTELXLEAPPPPQLRGRGGGGG 558
                        ||.|..:|.|   :....|:.:...||..|   ||..|.|
  Rat   492 ------------AGLYTCVAQNLVGADTKTVSVVVGHAPFQP---GRDKGPG 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/21 (19%)
		LRR_8	96..155	CDD:290566	16/58 (28%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_8	143..201	CDD:290566	14/57 (25%)
		leucine-rich repeat	145..168	CDD:275380	0/22 (0%)
		LRR_RI	147..397	CDD:238064	73/250 (29%)
		leucine-rich repeat	169..192	CDD:275380	10/22 (45%)
		leucine-rich repeat	193..217	CDD:275380	8/23 (35%)
		LRR_8	217..276	CDD:290566	23/58 (40%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	11/22 (50%)
		LRR_8	265..321	CDD:290566	16/55 (29%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	5/22 (23%)
		LRR_8	312..374	CDD:290566	15/61 (25%)
		leucine-rich repeat	314..335	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..363	CDD:275380	6/23 (26%)
		LRRCT	395..445	CDD:214507	17/63 (27%)
Lrrn2	NP_001170839.1	LRR_RI	46..288	CDD:238064	76/266 (29%)
		leucine-rich repeat	51..69	CDD:275380	5/17 (29%)
		leucine-rich repeat	71..94	CDD:275380	4/22 (18%)
		leucine-rich repeat	95..118	CDD:275380	8/22 (36%)
		LRR_8	117..177	CDD:290566	23/83 (28%)
		leucine-rich repeat	119..142	CDD:275380	8/46 (17%)
		leucine-rich repeat	143..166	CDD:275380	10/22 (45%)
		LRR_8	166..222	CDD:290566	19/56 (34%)
		leucine-rich repeat	167..190	CDD:275380	8/23 (35%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		LRR_RI	214..>372	CDD:238064	48/157 (31%)
		LRR_8	214..273	CDD:290566	22/58 (38%)
		leucine-rich repeat	215..238	CDD:275380	11/22 (50%)
		leucine-rich repeat	239..262	CDD:275380	7/22 (32%)
		leucine-rich repeat	263..286	CDD:275380	5/22 (23%)
		leucine-rich repeat	287..311	CDD:275380	5/23 (22%)
		LRR_8	310..371	CDD:290566	18/60 (30%)
		leucine-rich repeat	312..334	CDD:275380	5/21 (24%)
		leucine-rich repeat	337..360	CDD:275378	7/22 (32%)
		leucine-rich repeat	361..373	CDD:275378	5/11 (45%)
		TPKR_C2	369..412	CDD:301599	14/49 (29%)
		I-set	430..514	CDD:254352	23/111 (21%)
		Ig	438..514	CDD:299845	21/103 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21274
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4127
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8997
orthoMCL	1	0.900	-	-		OOG6_103993
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.860