DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and Lrrc15

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_659551.1	Gene:	Lrrc15 / 246296	RGDID:	70551	Length:	578	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	136/460 - (29%)
Similarity:	209/460 - (45%)	Gaps:	61/460 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LCLVLATLPVALGLA--NCPNGCECDDDTLMVNCGEGTLDVLP---------------------- 67
            |.|::.....|||||  .||:.|.|...: .|.|....:..:|
  Rat     7 LLLLVGCQAWALGLAYYGCPSECTCSRAS-QVECTGARIVAMPTPLPWNAMSLQVVNTHITELPE 70

  Fly    68 -IALN-PAIQRLVIKNNKLKTI-DSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHN 129
             :.|| .|:..|.::.|:|.|| ..:.:....|.:|.|:.|.:..:|.|.|.....|:.|.|.:|
  Rat    71 NLFLNISALIALKMEKNELSTIMPGAFRNLGSLRYLSLANNKLRMLPIRVFQDVNNLESLLLSNN 135

  Fly   130 KIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLR 194
            ::.|:....|...|.:..|.|.||.:..:....|..:|.|.:||||:|..:|:.|.....|.||:
  Rat   136 QLVQIQPAQFSQFSNLRELQLHGNNLESIPEEAFDHLVGLTKLNLGRNSFTHLSPRLFQHLGNLQ 200

  Fly   195 VLYLDDNTLTTVP-GELTFQALHSLAE------------------------LYLGTNSFMTIPGG 234
            ||.|.:|.|:.:| |  ||.||.:|.|                        |||..|....:|.|
  Rat   201 VLRLHENRLSDIPMG--TFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISQLPPG 263

  Fly   235 AFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQND 299
            .|..|..|.:|.|.|..|..:|......:.:||.|.|.:|.:.::....|..|.:|:.|.:..|.
  Rat   264 IFMQLPQLNKLTLFGNSLRELSPGVFGPMPNLRELWLYNNHITSLADNTFSHLNQLQVLILSHNQ 328

  Fly   300 FEVISSGAFSGLRELRHLEL-TGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPH 363
            ...||.|||:||..||.|.| |.|  |:.::|..|....||::::|.||: |.:|.......:..
  Rat   329 LTYISPGAFNGLTNLRELSLHTNA--LQDLDSNVFRSLANLQNISLQSNR-LRQLPGSIFANVNG 390

  Fly   364 LSTVVLKANQLSSLDEGLVP-WADLQTLDLSENPFECDCRLLWLRH-LLVSRNASGQYAPVICAY 426
            |:|:.|:.|.|.:|..|:.. ..:|..|.|.:||:.||..:|.|.: ||::|...|.....:|:.
  Rat   391 LTTIQLQNNNLENLPLGIFDHLVNLCELRLYDNPWRCDSDILPLHNWLLLNRARLGTDTLPVCSS 455

  Fly   427 PTALR 431
            |..:|
  Rat   456 PANVR 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	5/21 (24%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_8	143..201	CDD:290566	21/57 (37%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_RI	147..397	CDD:238064	88/276 (32%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		leucine-rich repeat	193..217	CDD:275380	12/24 (50%)
		LRR_8	217..276	CDD:290566	21/82 (26%)
		leucine-rich repeat	218..241	CDD:275380	10/46 (22%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		LRR_8	265..321	CDD:290566	21/56 (38%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	10/22 (45%)
		LRR_8	312..374	CDD:290566	20/62 (32%)
		leucine-rich repeat	314..335	CDD:275380	9/21 (43%)
		leucine-rich repeat	339..363	CDD:275380	6/23 (26%)
		LRRCT	395..445	CDD:214507	13/38 (34%)
Lrrc15	NP_659551.1	LRR_8	54..113	CDD:290566	12/58 (21%)
		LRR 1	54..75		0/20 (0%)
		LRR 2	78..99		6/20 (30%)
		leucine-rich repeat	79..102	CDD:275380	5/22 (23%)
		LRR_RI	<94..303	CDD:238064	62/210 (30%)
		LRR_8	102..161	CDD:290566	18/58 (31%)
		LRR 3	102..123		7/20 (35%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		LRR 4	126..147		6/20 (30%)
		leucine-rich repeat	127..150	CDD:275380	6/22 (27%)
		LRR_8	149..209	CDD:290566	22/59 (37%)
		LRR 5	150..171		5/20 (25%)
		leucine-rich repeat	151..174	CDD:275380	5/22 (23%)
		LRR 6	174..195		8/20 (40%)
		leucine-rich repeat	175..198	CDD:275380	9/22 (41%)
		LRR_8	198..257	CDD:290566	19/60 (32%)
		LRR 7	198..219		11/22 (50%)
		leucine-rich repeat	199..222	CDD:275380	12/24 (50%)
		LRR 8	222..243		2/20 (10%)
		leucine-rich repeat	223..246	CDD:275380	2/22 (9%)
		LRR_8	245..305	CDD:290566	19/59 (32%)
		LRR 9	246..267		7/20 (35%)
		leucine-rich repeat	247..270	CDD:275380	8/22 (36%)
		LRR 10	270..291		6/20 (30%)
		leucine-rich repeat	271..294	CDD:275380	6/22 (27%)
		LRR_8	293..353	CDD:290566	23/61 (38%)
		LRR 11	294..315		6/20 (30%)
		leucine-rich repeat	295..318	CDD:275380	7/22 (32%)
		LRR_4	318..358	CDD:289563	17/41 (41%)
		LRR 12	318..339		8/20 (40%)
		leucine-rich repeat	319..342	CDD:275380	10/22 (45%)
		LRR 13	342..363		9/22 (41%)
		leucine-rich repeat	343..364	CDD:275380	9/22 (41%)
		LRR_8	366..424	CDD:290566	17/58 (29%)
		LRR 14	366..387		7/21 (33%)
		leucine-rich repeat	367..387	CDD:275380	6/20 (30%)
		LRR 15	390..411		7/20 (35%)
		leucine-rich repeat	391..412	CDD:275380	7/20 (35%)
		TPKR_C2	423..>462	CDD:301599	13/38 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010