DRSC/TRiP Functional Genomics Resources

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Protein Alignment caps and Lingo2

DIOPT Version :9

Sequence 1:NP_001303391.1 Gene:caps / 39493 FlyBaseID:FBgn0023095 Length:811 Species:Drosophila melanogaster
Sequence 2:NP_001159471.1 Gene:Lingo2 / 242384 MGIID:2442298 Length:606 Species:Mus musculus


Alignment Length:423 Identity:131/423 - (30%)
Similarity:191/423 - (45%) Gaps:46/423 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 PHLGQAFSLCLCLCLCLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRL 77
            |.||          |.:||..:...:|   ||..|||......|:|....|..:|..:....:.|
Mouse    11 PFLG----------LAVVLLLMGSTIG---CPARCECSAQNKSVSCHRRRLLAIPEGIPIETKIL 62

  Fly    78 VIKNNKLKTIDSSMQF--YAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFL 140
            .:..|:||:|:.. :|  |..|..:|||.|.:..:...:|.....|:.|.|..|::..|....|.
Mouse    63 DLSKNRLKSINPE-EFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFT 126

  Fly   141 GLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTT 205
            |||.::.|::..|.|..|....|..:..|..|.:|.|.:.:|...|..||.:|..|.|:...||.
Mouse   127 GLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTA 191

  Fly   206 VPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNI-SGDALKGLVSLRFL 269
            ||.| ....|.||..|:|...:...:|..||:.|..|..|::....|.:: ..::|.|| :|..|
Mouse   192 VPTE-ALSHLRSLIALHLKHLNINNMPVYAFKRLFHLKNLEIDYWPLLDLMPANSLYGL-NLTSL 254

  Fly   270 DLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFS 334
            .:::..|..:|..||:.|..|..||:..|....|.:|.||.|..|:.|.:.||| ||.:|..:|.
Mouse   255 SITNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQ-LRTIEPHSFQ 318

  Fly   335 GNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFEC 399
            |...|..||:|.|.               |.|  |:.|..||      |.| |:.|.::.||..|
Mouse   319 GLRFLRVLNVSQNL---------------LET--LEENVFSS------PRA-LEVLSINNNPLAC 359

  Fly   400 DCRLLWLRHLLVSRNASGQYAPVICAYPTALRD 432
            |||||||.....:....||..  :||.|..:|:
Mouse   360 DCRLLWLLQRQPNLQFGGQQP--MCAGPDTIRE 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
capsNP_001303391.1 leucine-rich repeat 75..96 CDD:275380 7/22 (32%)
LRR_8 96..155 CDD:290566 17/58 (29%)
leucine-rich repeat 97..120 CDD:275380 6/22 (27%)
leucine-rich repeat 121..144 CDD:275380 8/22 (36%)
LRR_8 143..201 CDD:290566 17/57 (30%)
leucine-rich repeat 145..168 CDD:275380 5/22 (23%)
LRR_RI 147..397 CDD:238064 78/250 (31%)
leucine-rich repeat 169..192 CDD:275380 8/22 (36%)
leucine-rich repeat 193..217 CDD:275380 9/23 (39%)
LRR_8 217..276 CDD:290566 16/59 (27%)
leucine-rich repeat 218..241 CDD:275380 7/22 (32%)
leucine-rich repeat 242..265 CDD:275380 6/23 (26%)
LRR_8 265..321 CDD:290566 18/55 (33%)
leucine-rich repeat 266..289 CDD:275380 7/22 (32%)
leucine-rich repeat 290..313 CDD:275380 9/22 (41%)
LRR_8 312..374 CDD:290566 19/61 (31%)
leucine-rich repeat 314..335 CDD:275380 9/20 (45%)
leucine-rich repeat 339..363 CDD:275380 5/23 (22%)
LRRCT 395..445 CDD:214507 16/38 (42%)
Lingo2NP_001159471.1 LRRNT 27..60 CDD:214470 10/35 (29%)
leucine-rich repeat 39..57 CDD:275380 4/17 (24%)
LRR 1 58..79 6/21 (29%)
leucine-rich repeat 59..82 CDD:275380 7/23 (30%)
LRR_8 60..117 CDD:404697 17/57 (30%)
LRR 2 82..103 6/20 (30%)
leucine-rich repeat 83..106 CDD:275380 6/22 (27%)
LRR_8 106..165 CDD:404697 18/58 (31%)
LRR 3 106..127 6/20 (30%)
leucine-rich repeat 107..130 CDD:275380 8/22 (36%)
LRR 4 130..151 5/20 (25%)
leucine-rich repeat 131..154 CDD:275380 5/22 (23%)
LRR 5 154..175 6/20 (30%)
leucine-rich repeat 155..178 CDD:275380 8/22 (36%)
PPP1R42 176..>373 CDD:411060 75/223 (34%)
LRR 6 178..199 8/21 (38%)
leucine-rich repeat 179..202 CDD:275380 9/23 (39%)
LRR 7 202..223 7/20 (35%)
leucine-rich repeat 203..250 CDD:275380 13/47 (28%)
LRR 8 226..247 3/20 (15%)
LRR 9 250..271 6/20 (30%)
leucine-rich repeat 251..274 CDD:275380 7/22 (32%)
LRR 10 274..295 7/20 (35%)
leucine-rich repeat 275..298 CDD:275380 9/22 (41%)
LRR 11 298..319 9/21 (43%)
leucine-rich repeat 299..322 CDD:275380 10/23 (43%)
LRR 12 322..343 9/37 (24%)
leucine-rich repeat 323..343 CDD:275380 9/36 (25%)
LRRCT 355..408 CDD:214507 16/38 (42%)
Ig 411..500 CDD:416386
Ig strand A' 417..421 CDD:409353
Ig strand B 427..436 CDD:409353
Ig strand C 441..446 CDD:409353
Ig strand C' 449..451 CDD:409353
Ig strand D 460..463 CDD:409353
Ig strand E 466..473 CDD:409353
Ig strand F 479..487 CDD:409353
Ig strand G 490..500 CDD:409353
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8753
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5661
SonicParanoid 1 1.000 - - X1280
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.940

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