DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and FLRT3

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_037413.1	Gene:	FLRT3 / 23767	HGNCID:	3762	Length:	649	Species:	Homo sapiens

Alignment Length:	490	Identity:	113/490 - (23%)
Similarity:	182/490 - (37%)	Gaps:	118/490 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKT--IDSSM 91
            |.|...|:::...:||:.|.||..  .:.|.:..|..:|..:......|.::||::..  |.|.:
Human    17 LFLQVAPLSVMAKSCPSVCRCDAG--FIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDL 79

  Fly    92 QFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIA 156
            :             ::|.: ||.:.||..|.|...:..|.             :..|:|:.|.|.
Human    80 K-------------NLLKV-ERIYLYHNSLDEFPTNLPKY-------------VKELHLQENNIR 117

  Fly   157 ELEYRTFSPMVKLAELNLGQNRIS--HIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLA 219
            .:.|.:.|.:..|.||:|..|.:|  .|:..|....:.||:|:|..|.|:|:|..|.    .::.
Human   118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLP----RTIE 178

  Fly   220 ELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGL--HNISGDALKGLVSLRFLDLSDNRLPAIPTA 282
            ||.|..|...||...:.|.|..|.||.|.|..|  |.:.......||:|..|.|..|.|.|.|.
Human   179 ELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPV- 242

  Fly   283 AFQRL--GRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLS 345
               .|  ..|.:|.:..|....:...|||.||:|..|:::.
Human   243 ---NLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSN------------------------ 280

  Fly   346 SNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWAD-LQTLDLSENPFECDCRLLWLRHL 409
                                      |.||:|.:|:....| :..|.|..||:.|.|::.|:|..
Human   281 --------------------------NNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDW 319

  Fly   410 LVSRNASGQYAPVICAYPTALRDLPLAHLAEPLLGCAHGAASKQAIIGILVVACAALITTLALVL 474
            |.|.........::|..|..:|.:.:..|...|..|....          :|:...:.|.:...:
Human   320 LQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSG----------IVSTIQITTAIPNTV 374

  Fly   475 Y----------TCRHRIR--EMLKGHSALGRKERE 497
            |          |.:..|:  ::.|.|...|...|:
Human   375 YPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	5/22 (23%)
		LRR_8	96..155	CDD:290566	11/58 (19%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	3/22 (14%)
		LRR_8	143..201	CDD:290566	18/59 (31%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	67/256 (26%)
		leucine-rich repeat	169..192	CDD:275380	8/24 (33%)
		leucine-rich repeat	193..217	CDD:275380	9/23 (39%)
		LRR_8	217..276	CDD:290566	21/60 (35%)
		leucine-rich repeat	218..241	CDD:275380	8/22 (36%)
		leucine-rich repeat	242..265	CDD:275380	8/24 (33%)
		LRR_8	265..321	CDD:290566	18/57 (32%)
		leucine-rich repeat	266..289	CDD:275380	8/24 (33%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		LRR_8	312..374	CDD:290566	4/61 (7%)
		leucine-rich repeat	314..335	CDD:275380	2/20 (10%)
		leucine-rich repeat	339..363	CDD:275380	0/23 (0%)
		LRRCT	395..445	CDD:214507	13/49 (27%)
FLRT3	NP_037413.1	LRRNT	31..61	CDD:214470	8/31 (26%)
		Interaction with ADGRL3. /evidence=ECO:0000269\|PubMed:26235030	38..67		5/30 (17%)
		LRR 1. /evidence=ECO:0000255	59..80		5/20 (25%)
		leucine-rich repeat	61..84	CDD:275378	5/35 (14%)
		LRR 2. /evidence=ECO:0000255	84..104		6/20 (30%)
		leucine-rich repeat	85..104	CDD:275380	6/19 (32%)
		LRR 3. /evidence=ECO:0000255	105..126		5/33 (15%)
		LRR_8	106..166	CDD:290566	19/59 (32%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_RI	<120..259	CDD:238064	47/146 (32%)
		LRR 4. /evidence=ECO:0000255	129..150		7/20 (35%)
		leucine-rich repeat	130..155	CDD:275380	8/24 (33%)
		LRR 5. /evidence=ECO:0000255	155..175		9/23 (39%)
		leucine-rich repeat	156..176	CDD:275380	9/23 (39%)
		LRR_8	175..237	CDD:290566	21/61 (34%)
		LRR 6. /evidence=ECO:0000255	176..197		6/20 (30%)
		leucine-rich repeat	177..200	CDD:275380	8/22 (36%)
		LRR 7. /evidence=ECO:0000255	200..220		7/19 (37%)
		leucine-rich repeat	201..226	CDD:275380	8/24 (33%)
		LRR 8. /evidence=ECO:0000255	226..247		8/24 (33%)
		leucine-rich repeat	227..248	CDD:275380	8/24 (33%)
		LRR_8	247..306	CDD:290566	18/108 (17%)
		LRR_4	247..287	CDD:289563	13/89 (15%)
		LRR 9. /evidence=ECO:0000255	248..269		5/20 (25%)
		leucine-rich repeat	249..272	CDD:275380	7/22 (32%)
		LRR 10. /evidence=ECO:0000255	272..293		7/70 (10%)
		leucine-rich repeat	273..296	CDD:275380	7/72 (10%)
		LRRCT	305..356	CDD:214507	13/50 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		4/19 (21%)
		fn3	413..478	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870