DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and Lingo3

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001013780.2	Gene:	Lingo3 / 237403	MGIID:	3609246	Length:	589	Species:	Mus musculus

Alignment Length:	613	Identity:	156/613 - (25%)
Similarity:	225/613 - (36%)	Gaps:	192/613 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSSMQF 93
            |:|.|.|:|.|   ||..|||...|..|.||...|..:|..:....:.|.:..|:::.::.
Mouse    13 LLLPTAPLAAG---CPARCECSASTRTVACGRRRLTAIPEGIPAETRMLELSRNRIRCLNP---- 70

  Fly    94 YAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAEL 158
                       .|:.::|        .|:||.|:||.|..|....|..|..:.||.||||
Mouse    71 -----------GDLASLP--------TLEELDLNHNVIAHVEPGAFANLPRLRVLRLRGN----- 111

  Fly   159 EYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELYL 223
                        :|.|       |.|.....||:|.:|.|.:|.|..:. :.:||.|.||..|.:
Mouse   112 ------------QLKL-------IPPGVFTHLDSLTLLDLSENKLVILL-DFSFQDLRSLQRLEV 156

  Fly   224 GTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDA---LKGLVSLRF----------------- 268
            |.|..:.|...||..|.||..|.|....|.::|.::   |:||.:||.
Mouse   157 GDNDLVFISRRAFAGLLGLAELTLERCNLTSLSPESLGHLRGLGALRLRHLAIAALEDQNFQKLP 221

  Fly   269 ----------------------------LDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISS 305
                                        |.::...:.|:|.||.::...|..||:..|...::..
Mouse   222 GLSHLEIDNWPLLEEVAPGSLRGLNLTSLSITHTNITAVPAAALRQQAHLTCLNLSHNPISMVPR 286

  Fly   306 GAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLK 370
            |:|..|..||.|.|.|| .|..:|..||.|...:..||||.|.               |||  |:
Mouse   287 GSFRDLVRLRELHLAGA-LLAVIEPQAFVGLRQIRLLNLSDNL---------------LST--LE 333

  Fly   371 ANQLSSLDEGLVPWADLQTLDLSENPFECDCRLLWLRHLLVSRNASGQYAPVICAYPTALRDLPL 435
            .|...|::       .|:||.:..||..|||||||:.....:.|..|:..  .||.|..:|...|
Mouse   334 ENTFHSVN-------TLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLP--ACATPAEVRGDAL 389

  Fly   436 AHLAEPLLGCAHGAASKQAIIGILVVACAALITTLALVLYTCRH-RIREMLKGHSALGRKEREYQ 499
            .:|.:.:|                            ...:.||. :|||         |:.:...
Mouse   390 HNLPDSVL----------------------------FEYFVCRKPKIRE---------RRLQHVT 417

  Fly   500 KTFSDE-EYMSR----PPPGGGGVHP------AAGGYPYIAGNSRMIPVTELXLEAPPPPQLRG- 552
            .|..|: .::.|    |.|....|.|      ||.     .|.:|::|...|.: |...||..|
Mouse   418 ATEGDDVRFLCRAEGEPAPTVAWVTPQHHSVTAAS-----RGRARVLPGGTLTI-ADTRPQDSGT 476

  Fly   553 ------RGGGGGASTASGAVQQLQVPSA 574
                  ..||.....|:..||    |:|
Mouse   477 YTCVASNAGGNDTYFATLTVQ----PAA 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	2/20 (10%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	2/22 (9%)
		leucine-rich repeat	121..144	CDD:275380	10/22 (45%)
		LRR_8	143..201	CDD:290566	15/57 (26%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	78/297 (26%)
		leucine-rich repeat	169..192	CDD:275380	5/22 (23%)
		leucine-rich repeat	193..217	CDD:275380	8/23 (35%)
		LRR_8	217..276	CDD:290566	21/106 (20%)
		leucine-rich repeat	218..241	CDD:275380	8/22 (36%)
		leucine-rich repeat	242..265	CDD:275380	8/25 (32%)
		LRR_8	265..321	CDD:290566	18/100 (18%)
		leucine-rich repeat	266..289	CDD:275380	7/67 (10%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		LRR_8	312..374	CDD:290566	21/61 (34%)
		leucine-rich repeat	314..335	CDD:275380	10/20 (50%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	18/49 (37%)
Lingo3	NP_001013780.2	LRRNT	23..55	CDD:214470	12/34 (35%)
		leucine-rich repeat	34..53	CDD:275380	6/18 (33%)
		LRR 1	54..75		3/35 (9%)
		LRR	<55..353	CDD:227223	92/370 (25%)
		leucine-rich repeat	55..78	CDD:275380	4/45 (9%)
		LRR 2	78..99		9/20 (45%)
		leucine-rich repeat	79..102	CDD:275380	10/22 (45%)
		LRR 3	102..123		10/44 (23%)
		leucine-rich repeat	103..150	CDD:275380	20/71 (28%)
		LRR 4	126..147		6/21 (29%)
		LRR 5	150..171		8/20 (40%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		LRR 6	174..195		6/20 (30%)
		leucine-rich repeat	175..198	CDD:275380	6/22 (27%)
		leucine-rich repeat	199..222	CDD:275380	3/22 (14%)
		LRR 7	206..227		0/20 (0%)
		leucine-rich repeat	223..246	CDD:275380	0/22 (0%)
		LRR_8	246..302	CDD:338972	16/55 (29%)
		LRR 8	246..267		5/20 (25%)
		leucine-rich repeat	247..270	CDD:275380	5/22 (23%)
		LRR 9	270..291		6/20 (30%)
		leucine-rich repeat	271..292	CDD:275380	6/20 (30%)
		LRR 10	294..315		10/21 (48%)
		leucine-rich repeat	295..318	CDD:275380	11/23 (48%)
		LRR 11	318..339		10/37 (27%)
		leucine-rich repeat	321..342	CDD:275380	11/44 (25%)
		PCC	331..>405	CDD:188093	26/112 (23%)
		I-set	406..496	CDD:369462	24/104 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910