DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and Lingo1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	XP_006511149.1	Gene:	Lingo1 / 235402	MGIID:	1915522	Length:	647	Species:	Mus musculus

Alignment Length:	521	Identity:	134/521 - (25%)
Similarity:	194/521 - (37%)	Gaps:	127/521 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LCLVLATLPVALGLA-NCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSS 90
            |.|||.:  |..|.| .||..|||......|.|.......:|..: |...||
Mouse    54 LLLVLGS--VLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGI-PTETRL------------- 102

  Fly    91 MQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLI 155
                     |||..|.:.|:.:..||....|:||.|:.|.:..|....|..|..:..|.||.|.:
Mouse   103 ---------LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRL 158

  Fly   156 AELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAE 220
            ..:....|:.:..|.:|::.:|:|..:..:....|.||:.|.:.||.|..: ....|..|:||.:
Mouse   159 KLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYI-SHRAFSGLNSLEQ 222

  Fly   221 LYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLS-----DNRLP--- 277
            |.|...:..:||..|...|.||..|.||...::.|...:.|.|..|:.|::|     |...|
Mouse   223 LTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCL 287

  Fly   278 ----------------AIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLR 326
                            |:|..|.:.|..|..||:..|....|.......|..|:.::|.|.| |.
Mouse   288 YGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQ-LA 351

  Fly   327 RVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLV-PWADLQTL 390
            .||..||.|...|..||:|                         .|||::|:|... ...:|:||
Mouse   352 VVEPYAFRGLNYLRVLNVS-------------------------GNQLTTLEESAFHSVGNLETL 391

  Fly   391 DLSENPFECDCRLLWLRHLLVSRNASGQYAPVICAYPTALRDLPLAHLAEPLLGCAHGAASKQAI 455
            .|..||..|||||||:.......|.:.|..  .||.|..::........:.||.
Mouse   392 ILDSNPLACDCRLLWVFRRRWRLNFNRQQP--TCATPEFVQGKEFKDFPDVLLP----------- 443

  Fly   456 IGILVVACAALITTLALVLYTCRHRIREMLKGHSALGRKEREYQKTFSDE----EYMSR----PP 512
                             ..:|||       :.|.    ::|:.|:.|.||    :::.|    ||
Mouse   444 -----------------NYFTCR-------RAHI----RDRKAQQVFVDEGHTVQFVCRADGDPP 480

  Fly   513 P 513
            |
Mouse   481 P 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	2/20 (10%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_8	143..201	CDD:290566	13/57 (23%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_RI	147..397	CDD:238064	73/274 (27%)
		leucine-rich repeat	169..192	CDD:275380	5/22 (23%)
		leucine-rich repeat	193..217	CDD:275380	7/23 (30%)
		LRR_8	217..276	CDD:290566	20/63 (32%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	7/22 (32%)
		LRR_8	265..321	CDD:290566	17/79 (22%)
		leucine-rich repeat	266..289	CDD:275380	9/46 (20%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	15/61 (25%)
		leucine-rich repeat	314..335	CDD:275380	9/20 (45%)
		leucine-rich repeat	339..363	CDD:275380	4/23 (17%)
		LRRCT	395..445	CDD:214507	16/49 (33%)
Lingo1	XP_006511149.1	LRRNT	68..102	CDD:214470	9/34 (26%)
		LRR	<93..398	CDD:227223	92/354 (26%)
		leucine-rich repeat	100..123	CDD:275380	9/44 (20%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR_8	147..206	CDD:338972	15/58 (26%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..219	CDD:275380	13/47 (28%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..291	CDD:275380	12/46 (26%)
		leucine-rich repeat	292..315	CDD:275380	4/22 (18%)
		leucine-rich repeat	316..339	CDD:275380	6/22 (27%)
		leucine-rich repeat	340..363	CDD:275380	10/23 (43%)
		leucine-rich repeat	364..384	CDD:275380	9/44 (20%)
		PCC	368..>448	CDD:188093	27/134 (20%)
		Ig	466..541	CDD:386229	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12115
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8753
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910