DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and dma-1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_492253.1	Gene:	dma-1 / 187968	WormBaseID:	WBGene00011345	Length:	603	Species:	Caenorhabditis elegans

Alignment Length:	639	Identity:	153/639 - (23%)
Similarity:	238/639 - (37%)	Gaps:	170/639 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LCLCLVLATLPVALGLANCPNGCECD--DDTLMVNCGEG---------TLDVLPIAL-----NPA 73
            |.||.:  .||     ::|||.||||  |.:..|.|.:.         .|:.||:.|     .|.
Worm    13 LVLCSI--ALP-----SSCPNLCECDQNDSSWSVYCRKAIINDTIYAEILNQLPLTLRSLHIQPP 70

  Fly    74 IQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKT 138
            ..|  |.:|||:..|:..:| |||..|.| .|..:....||... ..|:.|.|..|.|...:...
Worm    71 SNR--IGSNKLRWNDNINRF-AQLRVLRL-INCQIPAMSRSIRL-PSLEVLDLHSNNIEHATMSN 130

  Fly   139 FLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTL 203
            |.|:..:.||:|..|.:..|....|:.:..|..|:|..|.||.:..:.|.||::||||.||.|.:
Worm   131 FGGMPKLRVLDLSSNHLNILPTGVFTYLRALRSLSLSNNTISDLSTNLLRGLNSLRVLRLDRNPI 195

  Fly   204 TTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRF 268
            ........|..:..|.||||...:..:|...|...:..|.:|.:.|..|..:....|:.|..|..
Worm   196 PIEHINELFTDVSQLDELYLNHCNLSSIYSLALDRIPQLRQLGIGGNNLKMVPTKELRSLPQLSV 260

  Fly   269 LDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFS----GLRELRHLELTGAQRLRRVE 329
            ||||.|.:..|...||... .:.:|::..|...:.....|:    ....||||:|
Worm   261 LDLSHNSIQEITACAFCNT-NISKLDLSHNLLGISKDSPFNEDAFRTMPLRHLDL---------- 314

  Fly   330 SGAFSGNTNLEHLNLSSNKQL----NELSSIALGG------------------------------ 360
                    :..|:|...:|.|    .||:||||.|
Worm   315 --------SFNHMNDFDSKWLGWAQEELTSIALSGNFLKNFEESWTYTLKSLIHLELAYNHIKFI 371

  Fly   361 ---LP----HLSTVVLKANQLSSLDEG---LVPWADLQTLDLSE--------------------- 394
               ||    ||.::.:..|:|:.|.:.   |:|  :::|.|::.
Worm   372 PVQLPSRYYHLISLNISGNELTYLPDNINTLLP--NVKTFDITANRFHTFSHTDLAFLNNVEQVY 434

  Fly   395 ---NPFECDCRLLWL----------RHLLVSRNASGQYAPVICAYPTALRDLPLAHLAE-----P 441
               ||::|.|.:..|          ||:|       .|..|.||.|:.:....:..:.:     .
Worm   435 VDGNPWDCSCAIQGLQVHMRDRYAMRHIL-------NYDNVRCATPSLVEGHSVLAITDVNDCAV 492

  Fly   442 LLGCAHGAASKQAIIGILVVACAALITTLALVLYTCRHRIREMLKGHSALGRKEREYQKTFSDEE 506
            |.|..:|......:  ::::|...|...|.|::..|.:.:|            ||:|:.::...|
Worm   493 LFGARYGLTQTSEM--LILLAGVLLFAALLLMILGCIYFLR------------ERQYKGSYVTRE 543

  Fly   507 YMSRPPPGGGGVHPAAGGY------------PYIAGNSRMIPVTELXLEAPPPP 548
            : ||.|......|..:...            |::...........|...|||.|
Worm   544 H-SRTPLTMANTHSCSSSTNDTHGPLSPPFDPFLVSTETFKATPPLIPPAPPKP 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	7/20 (35%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_8	143..201	CDD:290566	21/57 (37%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	76/321 (24%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		leucine-rich repeat	193..217	CDD:275380	8/23 (35%)
		LRR_8	217..276	CDD:290566	19/58 (33%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		LRR_8	265..321	CDD:290566	17/59 (29%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	3/26 (12%)
		LRR_8	312..374	CDD:290566	21/102 (21%)
		leucine-rich repeat	314..335	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..363	CDD:275380	13/64 (20%)
		LRRCT	395..445	CDD:214507	14/64 (22%)
dma-1	NP_492253.1	LRR_8	90..147	CDD:338972	18/58 (31%)
		leucine-rich repeat	91..112	CDD:275380	6/22 (27%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR	136..430	CDD:227223	75/314 (24%)
		leucine-rich repeat	137..160	CDD:275380	6/22 (27%)
		leucine-rich repeat	161..184	CDD:275380	9/22 (41%)
		leucine-rich repeat	185..209	CDD:275380	8/23 (35%)
		leucine-rich repeat	210..233	CDD:275380	7/22 (32%)
		leucine-rich repeat	234..257	CDD:275380	6/22 (27%)
		leucine-rich repeat	258..280	CDD:275380	9/22 (41%)
		leucine-rich repeat	281..307	CDD:275380	3/25 (12%)
		leucine-rich repeat	309..357	CDD:275380	16/65 (25%)
		leucine-rich repeat	382..405	CDD:275380	6/24 (25%)
		leucine-rich repeat	406..429	CDD:275380	2/22 (9%)
		TPKR_C2	438..>478	CDD:387596	13/46 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28910
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020