Protein Alignment caps and let-4

DIOPT Version :10

• Sequence 1: NP_001303391.1
• Gene: caps / 39493
• FlyBaseID: FBgn0023095
• Length: 811
• Species: Drosophila melanogaster
• Sequence 2: NP_510425.2
• Gene: let-4 / 181554
• WormBaseID: WBGene00002282
• Length: 773
• Species: Caenorhabditis elegans
• Alignment Length: 698
• Identity: 162/698 - (23%)
• Similarity: 279/698 - (39%)
• Gaps: 125/698 - (17%)

  Fly    25 LCLCLVLATLPVALGLANCP----NGCECDD--DTLMVNC----GEGTLDVLPIALNPA----IQ 75
            |.|||:|.:..:......||    ..|.|.:  ..::::|    ..|.|.:  |..|.|    ||
 Worm     3 LLLCLLLFSTLLINSTNACPGVITQACFCSEVHSGIVLDCSNSSASGILQI--IRTNQAQVGLIQ 65

  Fly    76 RLVIKNNKLKTIDSSMQFYAQLTF--LDLSFNDMLTIPERSFA-YHAKLQELHLDHNKIGQVSNK 137
            .|.:  |:.:.::....|::.|..  ||||.|.:..|.:.:|| .:..|:|:.|:||.|.:|...
 Worm    66 SLTM--NQAELVELPPNFFSGLFIRRLDLSQNKIKKIDDAAFAGINPVLEEVVLNHNLIEKVPAA 128

  Fly   138 TFLGLSTISVLNLRGNLIAEL-EYRTFSPMVKLAELNLGQNRISHIDPHALDGLDN-LRVLYLDD 200
            ...||..:..|:|..|.|.|: |...|..:.||.::|||.|:|..|.......:.| ::.:.|..
 Worm   129 ALAGLPNLLRLDLSNNSIVEIQEQEIFPNLNKLYDINLGSNKIFSIHTSTFQNVKNSIQTINLGH 193

  Fly   201 NTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVS 265
            |.:|.||.. ..:.|..|..|:|..|....:....|.:|..|..|:|.|..:|.::..|...:.|
 Worm   194 NNMTAVPSS-AIRGLKQLQSLHLHKNRIEQLDALNFLNLPVLNLLNLAGNQIHELNRQAFLNVPS 257

  Fly   266 LRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVES 330
            ||:|.||.|::..:....||...:||.|::..|:...|.:.:.|||::||.|.| ...::..:.|
 Worm   258 LRYLYLSGNKITKLTAYQFQTFEQLEMLDLTNNEIGAIPANSLSGLKQLRQLYL-AHNKISNISS 321

  Fly   331 GAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLD-EGLVPWADLQTLDLSE 394
            .||: |:::..|.|||| :|..|::..:.|||:|..|..:.||:.::: ......|.|..|||::
 Worm   322 NAFT-NSSIVVLVLSSN-ELKTLTAGIISGLPNLQQVSFRDNQIKTINRNAFYDAASLVMLDLAK 384

  Fly   395 N--------PFECDCRLLWLRHLLVSRNASGQYAPVICAYPTA-LRDLPLA-----HLAE----- 440
            |        .|.....|| |..|..::.....|:.......|. |::.||.     |:.:
 Worm   385 NQLTEIAPTTFLAQLNLL-LVDLSENKLPKTPYSAFNSRVGTVLLKENPLVCTENLHMLQQGTGV 448

  Fly   441 -----PLLGCAHGAASKQAIIGILVVACAALITTLALVLYTCRHRI------------------- 481
                 |.:.|......|...:.:.:|..:.:.|....::...:.:|
 Worm   449 YVRDSPDIICGRKPTPKPEPVLVPIVTDSLISTQRPALVQIPKMQIHRNVHTTTGDQAPQIPSGA 513

  Fly   482 ---------REMLKGHSALGRKEREYQKTFSDEEYMSRPPPGGGGVHPAAGGYPYIAGNSRMIPV 537
                     |.:.:|||..               .:.:|......|.|          ...:.|:
 Worm   514 FQQIDLGKSRSLPRGHSRF---------------ILDKPSTREQSVEP----------TEELTPI 553

  Fly   538 TELXLEAPPPPQLRGRGGGGGASTASGAVQQLQVPSAVDQASNSFAQLSH-IHYM-----TNNGQ 596
            ..:.|.: ...::|......|.|..|......::||..|........|.. :.::     .:..:
 Worm   554 QPIILPS-REDEIRQSSMEAGTSQESVEATSQKIPSTTDIIDRPNVVLPFPVPFLKRGPNLSESK 617

  Fly   597 QQQAQQQQSTSKMHHSQQDMRLLACNGGKPLNATSLPRHRPPVVQEST 644
            :.::....|||::.|:.....|:.            |...|.|.|.||
 Worm   618 KVESTDMPSTSQVFHTLPPSILIE------------PGSTPKVAQPST 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/20 (20%)
		LRR_8	96..155	CDD:404697	21/61 (34%)
		leucine-rich repeat	97..120	CDD:275380	9/25 (36%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		LRR	135..>398	CDD:443914	81/273 (30%)
		leucine-rich repeat	145..168	CDD:275380	7/23 (30%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		leucine-rich repeat	193..217	CDD:275380	6/23 (26%)
		leucine-rich repeat	218..241	CDD:275380	6/22 (27%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..335	CDD:275380	7/20 (35%)
		leucine-rich repeat	339..363	CDD:275380	9/23 (39%)
		LRRCT	395..445	CDD:214507	13/73 (18%)
let-4	NP_510425.2	leucine-rich repeat	66..86	CDD:275380	3/21 (14%)
		LRR	85..414	CDD:443914	102/333 (31%)
		leucine-rich repeat	88..111	CDD:275380	8/22 (36%)
		leucine-rich repeat	112..135	CDD:275380	9/22 (41%)
		leucine-rich repeat	136..160	CDD:275380	7/23 (30%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		leucine-rich repeat	186..209	CDD:275380	6/23 (26%)
		leucine-rich repeat	210..257	CDD:275380	12/46 (26%)
		leucine-rich repeat	258..281	CDD:275380	8/22 (36%)
		leucine-rich repeat	282..305	CDD:275380	8/22 (36%)
		leucine-rich repeat	306..328	CDD:275380	8/23 (35%)
		leucine-rich repeat	329..350	CDD:275380	7/21 (33%)
		leucine-rich repeat	353..400	CDD:275380	11/46 (24%)
		leucine-rich repeat	356..376	CDD:275380	3/19 (16%)
		leucine-rich repeat	401..419	CDD:275380	5/18 (28%)