DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and lron-1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_510424.4	Gene:	lron-1 / 181553	WormBaseID:	WBGene00008093	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	609	Identity:	146/609 - (23%)
Similarity:	243/609 - (39%)	Gaps:	131/609 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GQAFSLCLCLCL---CLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNP----- 72
            |..:|.|..|.|   |...:|...|:.: ||..|...|.....::.....:|.|.|:..|
Worm    12 GWVYSQCPTLQLQEPCTCTSTRYEAVSI-NCDGGSSLDAVLESLSNSPQAIDSLTISNTPIEKMP 75

  Fly    73 -------AIQRLVIKNNKLKT-----------------------ID----SSMQFYAQLTFLDLS 103
                   .|::|.::||.|::                       ||    |.:....||..|.|.
Worm    76 GYAFQGFQIKKLFLRNNGLRSFHPNTFTGNLENSLEELEIRGNYIDGIPQSGVSILKQLKILSLP 140

  Fly   104 FNDMLTIPERSF-AYHAK--LQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSP 165
            .|.:..:.:.:| :||::  |.:|.|..|.:..:.....|||..:|.|:|..||::|:..:....
Worm   141 DNLIEYVQDNAFLSYHSRDSLLKLDLSANNLTAIHPTGLLGLENLSQLSLDKNLLSEIPSQALEN 205

  Fly   166 MVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMT 230
            :..|.:|:||.|||..|..::|. |.||:.|.|:.|.:..:|.: :|.....|:.||||.|...:
Worm   206 IPSLEDLSLGVNRIHTISRNSLP-LPNLKSLSLEVNQIRLIPSD-SFSETPLLSYLYLGNNLLTS 268

  Fly   231 IPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQR---LGRLEQ 292
            |....|..:.||..|.:  :...:|:.....|.:|::...|      .|...|||.   |.|||.
Worm   269 IDASMFLHIGGLKVLSM--SNNKDITSIQANGKLSVQQFKL------CICILAFQHAPSLIRLEL 325

  Fly   293 LNIGQNDFEVISSGAFSGLRELRHLE--LTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSS 355
            .:...:..|..|      |::::|::  |....::.|:....||....|..|:||.| .:|.:..
Worm   326 FDCSISRIEPKS------LQKVQHIQVILLSRNQITRISHDTFSNLPELSELDLSGN-SINAVDD 383

  Fly   356 IALGGLPHLSTVVLKANQLSSLDEGLVPWADLQ--------TLDLSENPFECDCRLLWLRHLLVS 412
            .|...||.|:::.|.:|:|.||...::..:.:|        .|.:..||:.||..|:|||..|..
Worm   384 FAFSQLPMLTSLDLSSNRLESLPSNVIYDSLMQKKTSPVQRKLSIQNNPWRCDKDLMWLRKWLRD 448

  Fly   413 R----NASGQYAPVICAYPTALRDLPLAHLAEPL---------------------------LGC- 445
            .    .|:....|..|..|:.|..|.|......|                           ||.
Worm   449 NGDVTTAASNSPPAKCWTPSNLSGLDLRQTDSKLPHKTTKPPVDQFQYKNQQVTNSNGTSQLGYQ 513

  Fly   446 -----AHGAASKQAIIGILV---VACAAL--ITTLALVLYTCRHR-------------IREMLKG 487
                 .:|.|....|:||::   |:|..|  :.....:.|..:.:             ||.|..|
Worm   514 NPHTEVNGLALVGLILGIVLVVFVSCIILGYLMRFIFLSYEAKTKPNVFGSTISSSGCIRNMYGG 578

  Fly   488 HSALGRKEREYQKTFSDEEYMSRP 511
            ...|..::..:..:.::..|::||
Worm   579 DGTLVSEDHGHPSSANNNVYLNRP 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	7/47 (15%)
		LRR_8	96..155	CDD:290566	19/61 (31%)
		leucine-rich repeat	97..120	CDD:275380	7/23 (30%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_8	143..201	CDD:290566	20/57 (35%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	71/262 (27%)
		leucine-rich repeat	169..192	CDD:275380	10/22 (45%)
		leucine-rich repeat	193..217	CDD:275380	6/23 (26%)
		LRR_8	217..276	CDD:290566	15/58 (26%)
		leucine-rich repeat	218..241	CDD:275380	8/22 (36%)
		leucine-rich repeat	242..265	CDD:275380	4/22 (18%)
		LRR_8	265..321	CDD:290566	15/60 (25%)
		leucine-rich repeat	266..289	CDD:275380	6/25 (24%)
		leucine-rich repeat	290..313	CDD:275380	5/22 (23%)
		LRR_8	312..374	CDD:290566	17/63 (27%)
		leucine-rich repeat	314..335	CDD:275380	4/22 (18%)
		leucine-rich repeat	339..363	CDD:275380	8/23 (35%)
		LRRCT	395..445	CDD:214507	18/80 (23%)
lron-1	NP_510424.4	PRK15370	<58..>289	CDD:185268	61/234 (26%)
		leucine-rich repeat	85..109	CDD:275380	4/23 (17%)
		leucine-rich repeat	110..133	CDD:275380	3/22 (14%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..231	CDD:275380	10/22 (45%)
		leucine-rich repeat	232..255	CDD:275380	6/23 (26%)
		leucine-rich repeat	256..279	CDD:275380	8/22 (36%)
		leucine-rich repeat	280..319	CDD:275380	10/46 (22%)
		leucine-rich repeat	320..343	CDD:275380	7/28 (25%)
		LRR_8	343..402	CDD:338972	17/59 (29%)
		leucine-rich repeat	344..367	CDD:275380	4/22 (18%)
		leucine-rich repeat	368..391	CDD:275380	8/23 (35%)
		leucine-rich repeat	392..410	CDD:275380	6/17 (35%)
		leucine-rich repeat	414..435	CDD:275378	4/20 (20%)
		LRRCT	431..>472	CDD:214507	14/40 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D187891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020