DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and pan-1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_497925.1	Gene:	pan-1 / 175596	WormBaseID:	WBGene00003915	Length:	594	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	138/579 - (23%)
Similarity:	219/579 - (37%)	Gaps:	153/579 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LCLCL--------------CLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPA 73
            :|:|.              |...:...|:..||:. ||.|....|:.    :.|::|||..|
Worm    42 VCICADNGIFSTVKGFTIECESASIASVSENLASL-NGTELGRLTIR----DSTVNVLPQDL--- 98

  Fly    74 IQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSF-AYHAKLQELHLDHNKIGQVSNK 137
            .:.:..|..||:....|                  |:...|| :.....:.|.|..|:|.::...
Worm    99 FENVFAKQVKLERCGLS------------------TLQPNSFQSLGGSAELLSLRENRIKKLEKG 145

  Fly   138 TFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNT 202
            .|.||.::..|:|..|.|.|::...|..:.|:.||.|.:|.|..:.....||:.||:.|.|.:..
Worm   146 LFTGLKSLKTLDLAMNKIQEIDVGAFEELKKVEELLLNENDIRVLKTGTFDGMKNLKKLTLQNCN 210

  Fly   203 LTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLR 267
            |..:. :..|:.|:||.:|.|..|:...|....|..||.|..|||   |.:.||...:|....|.
Worm   211 LEIIQ-KGAFRGLNSLEQLILSNNNLENIDWTIFSALKNLRVLDL---GSNKISNVEMKSFPKLE 271

  Fly   268 FLDLSDNR-----------LPAIPTAAFQR-----LG-----------RLEQLNIGQNDFEVISS 305
            .|.|::|.           ||::..|.|.|     :|           |:|.|::.:|:...||.
Worm   272 KLVLNNNTIDSMKSIKLKDLPSLVVALFDRNKIESIGDMDMFGLTRSDRIETLSLARNNLSQISP 336

  Fly   306 GAFSG-------LRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSN-----------KQL-- 350
            .||..       |.:...:|...:....:|.:...:....|..|.||||           |.|
Worm   337 KAFQHTPNLITLLLQYNQIEELSSHSPSQVRTPFLASLKKLVTLQLSSNNLSVIRSDELPKSLSS 401

  Fly   351 -----NELSSI---ALGGLPHLSTVVLKANQLSSLDEG----LVPWADLQTLDLSENPFECDCR- 402
                 |.:|.|   ||.|: .:..:.|.:|:|:.|.:|    ..| ..::.:|:|.||:.|.|.
Worm   402 LALDHNVISKIEARALEGM-EIKRLYLHSNKLNYLYQGTFDSFSP-KSVEAVDVSLNPWVCVCND 464

  Fly   403 -LLWLRHLLVSRNASGQYAPVICAYPTALRDLPLAHLAEPLLGCAH----GAASKQAII------ 456
             ..||                    |..|.....|.:||..|||..    |......::
Worm   465 PKEWL--------------------PRWLEASEEADVAEGALGCLAIPNCGQKEGSTVMPEEEEV 509

  Fly   457 ---GILVVACAALITTLALV-------LYTCRHRIREMLKGHSALGRKEREYQKTFSDE 505
               |.:.|| |.::|.:.:|       ||....|.:..|:|.    |.:.:..|...::
Worm   510 YRSGWITVA-ATILTIVTIVIMVIIAMLYFKDARYQFPLRGR----RSDSDLHKLIEND 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/20 (20%)
		LRR_8	96..155	CDD:290566	13/59 (22%)
		leucine-rich repeat	97..120	CDD:275380	3/23 (13%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_8	143..201	CDD:290566	18/57 (32%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	82/308 (27%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		leucine-rich repeat	193..217	CDD:275380	6/23 (26%)
		LRR_8	217..276	CDD:290566	21/69 (30%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	8/22 (36%)
		LRR_8	265..321	CDD:290566	20/89 (22%)
		leucine-rich repeat	266..289	CDD:275380	10/49 (20%)
		leucine-rich repeat	290..313	CDD:275380	8/29 (28%)
		LRR_8	312..374	CDD:290566	18/82 (22%)
		leucine-rich repeat	314..335	CDD:275380	2/20 (10%)
		leucine-rich repeat	339..363	CDD:275380	14/44 (32%)
		LRRCT	395..445	CDD:214507	12/51 (24%)
pan-1	NP_497925.1	leucine-rich repeat	130..152	CDD:275380	7/21 (33%)
		LRR_8	132..187	CDD:290566	18/54 (33%)
		leucine-rich repeat	153..176	CDD:275380	6/22 (27%)
		leucine-rich repeat	177..200	CDD:275380	7/22 (32%)
		LRR_8	199..259	CDD:290566	21/63 (33%)
		leucine-rich repeat	201..224	CDD:275380	6/23 (26%)
		LRR_RI	224..434	CDD:238064	55/213 (26%)
		leucine-rich repeat	225..248	CDD:275380	7/22 (32%)
		leucine-rich repeat	249..269	CDD:275380	8/22 (36%)
		LRR_8	268..355	CDD:290566	19/86 (22%)
		leucine-rich repeat	270..293	CDD:275380	5/22 (23%)
		leucine-rich repeat	294..320	CDD:275380	4/25 (16%)
		LRR_8	320..387	CDD:290566	17/66 (26%)
		leucine-rich repeat	321..344	CDD:275380	7/22 (32%)
		LRR_8	375..432	CDD:290566	16/57 (28%)
		leucine-rich repeat	377..398	CDD:275380	6/20 (30%)
		leucine-rich repeat	399..420	CDD:275380	6/20 (30%)
		leucine-rich repeat	423..442	CDD:275380	5/18 (28%)
		LRR_RI	80..326	CDD:238064	72/274 (26%)
		leucine-rich repeat	81..104	CDD:275380	6/29 (21%)
		leucine-rich repeat	105..128	CDD:275380	7/40 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010