DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and Lrrn1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_032542.1	Gene:	Lrrn1 / 16979	MGIID:	106038	Length:	716	Species:	Mus musculus

Alignment Length:	429	Identity:	111/429 - (25%)
Similarity:	186/429 - (43%)	Gaps:	60/429 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ATLPVALGL------------ANCPNGCECD-----------DDTLMVNCGEGTLDVLPIALNPA 73
            |...|.|||            :.||..|.|:           .:...|:|.:..|..:|..|:..
Mouse     9 AACQVVLGLLITSLTESSILTSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPGNLSSD 73

  Fly    74 IQRLVIKNNKL-KTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNK 137
            .|.|::::|.: ||:|...|.: .||.||.|.|:...|.|...|...:|..|||:.|:|.::::.
Mouse    74 TQVLLLQSNNIAKTVDELQQLF-NLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQISEMTDY 137

  Fly   138 TFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNT 202
            ....||.:..|.:..|.|:.:....||.:..|..|:|..|::..||....|...||.:|.:.:|.
Mouse   138 CLQDLSNLQELYINHNQISTISANAFSGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENP 202

  Fly   203 LTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLR 267
            :..:                |..|         |:.|..|..|.|.|..|.::.|:||.||.||.
Mouse   203 VIGI----------------LDMN---------FRPLSNLRSLVLAGMYLTDVPGNALVGLDSLE 242

  Fly   268 FLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGA 332
            .|...||:|..:|..|.|::..|:.|::.:|....|..|.|..:..|:.|.:.....|..|:..|
Mouse   243 SLSFYDNKLIKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYA 307

  Fly   333 FSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLV-PWADLQTLDLSENP 396
            ......|..|..::|.:|:.:..:|...:|.|.:::|..|.|:::.:..| ...:|:.:.:..||
Mouse   308 LDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAVYQKTVESLPNLREISIHSNP 372

  Fly   397 FECDCRLLWLRHLLVSRNASG----QYAPVICAYPTALR 431
            ..|||.:.|     ::.|.:.    :...:.||.|...|
Mouse   373 LRCDCVIHW-----INSNKTNIRFMEPLSMFCAMPPEYR 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	7/21 (33%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_8	143..201	CDD:290566	16/57 (28%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_RI	147..397	CDD:238064	63/250 (25%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		leucine-rich repeat	193..217	CDD:275380	3/23 (13%)
		LRR_8	217..276	CDD:290566	19/58 (33%)
		leucine-rich repeat	218..241	CDD:275380	4/22 (18%)
		leucine-rich repeat	242..265	CDD:275380	10/22 (45%)
		LRR_8	265..321	CDD:290566	17/55 (31%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	14/61 (23%)
		leucine-rich repeat	314..335	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	11/41 (27%)
Lrrn1	NP_032542.1	LRR_RI	11..273	CDD:238064	78/287 (27%)
		leucine-rich repeat	54..73	CDD:275380	5/18 (28%)
		LRR 1	73..95		7/21 (33%)
		leucine-rich repeat	74..96	CDD:275380	7/22 (32%)
		LRR 2	96..117		8/20 (40%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		LRR_8	119..179	CDD:290566	17/59 (29%)
		LRR 3	120..141		6/20 (30%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR 4	144..165		4/20 (20%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR 5	168..189		6/20 (30%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		LRR 6	192..213		7/45 (16%)
		leucine-rich repeat	193..216	CDD:275380	7/47 (15%)
		LRR_RI	211..>376	CDD:238064	46/164 (28%)
		LRR_8	215..275	CDD:290566	22/59 (37%)
		LRR 7	216..237		8/20 (40%)
		leucine-rich repeat	217..240	CDD:275380	10/22 (45%)
		LRR 8	240..261		8/20 (40%)
		leucine-rich repeat	241..264	CDD:275380	8/22 (36%)
		LRR_8	263..323	CDD:290566	13/59 (22%)
		LRR 9	264..285		6/20 (30%)
		leucine-rich repeat	265..288	CDD:275380	6/22 (27%)
		leucine-rich repeat	289..313	CDD:275380	5/23 (22%)
		LRR_8	312..373	CDD:290566	13/60 (22%)
		leucine-rich repeat	314..335	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..362	CDD:275378	5/22 (23%)
		leucine-rich repeat	363..375	CDD:275378	3/11 (27%)
		LRRCT	371..419	CDD:214507	11/41 (27%)
		I-set	429..516	CDD:254352
		Ig	431..516	CDD:299845
		fn3	531..600	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4234
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8753
orthoMCL	1	0.900	-	-		OOG6_103993
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.860