DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and LINGO2

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001245211.1	Gene:	LINGO2 / 158038	HGNCID:	21207	Length:	606	Species:	Homo sapiens

Alignment Length:	423	Identity:	129/423 - (30%)
Similarity:	190/423 - (44%)	Gaps:	46/423 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PHLGQAFSLCLCLCLCLVLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRL 77
            |.||          |.:||..:...:|   ||..|||......|:|....|..:|..:....:.|
Human    11 PFLG----------LAVVLIFMGSTIG---CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKIL 62

  Fly    78 VIKNNKLKTIDSSMQF--YAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFL 140
            .:..|:||:::.. :|  |..|..:|||.|.:..:...:|.....|:.|.|..|::..|....|.
Human    63 DLSKNRLKSVNPE-EFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFT 126

  Fly   141 GLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTT 205
            |||.::.|::..|.|..|....|..:..|..|.:|.|.:.:|...|..||.:|..|.|:...||.
Human   127 GLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTA 191

  Fly   206 VPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDL-RGAGLHNISGDALKGLVSLRFL 269
            ||.| ....|.||..|:|...:...:|..||:.|..|..|:: ....|..:..::|.|| :|..|
Human   192 VPTE-ALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGL-NLTSL 254

  Fly   270 DLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFS 334
            .:::..|..:|..||:.|..|..||:..|....|.:|.||.|..|:.|.:.||| ||.:|..:|.
Human   255 SVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQ-LRTIEPHSFQ 318

  Fly   335 GNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFEC 399
            |...|..||:|.|.               |.|  |:.|..||      |.| |:.|.::.||..|
Human   319 GLRFLRVLNVSQNL---------------LET--LEENVFSS------PRA-LEVLSINNNPLAC 359

  Fly   400 DCRLLWLRHLLVSRNASGQYAPVICAYPTALRD 432
            ||||||:.....:....||..  :||.|..:|:
Human   360 DCRLLWILQRQPTLQFGGQQP--MCAGPDTIRE 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	6/22 (27%)
		LRR_8	96..155	CDD:290566	17/58 (29%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_8	143..201	CDD:290566	17/57 (30%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_RI	147..397	CDD:238064	78/250 (31%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..217	CDD:275380	9/23 (39%)
		LRR_8	217..276	CDD:290566	16/59 (27%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	6/23 (26%)
		LRR_8	265..321	CDD:290566	18/55 (33%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		LRR_8	312..374	CDD:290566	19/61 (31%)
		leucine-rich repeat	314..335	CDD:275380	9/20 (45%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	15/38 (39%)
LINGO2	NP_001245211.1	LRRNT	27..60	CDD:214470	10/35 (29%)
		leucine-rich repeat	39..57	CDD:275380	4/17 (24%)
		LRR 1	58..79		5/21 (24%)
		leucine-rich repeat	59..82	CDD:275380	6/23 (26%)
		LRR_8	60..117	CDD:316378	16/57 (28%)
		LRR 2	82..103		6/20 (30%)
		leucine-rich repeat	83..106	CDD:275380	6/22 (27%)
		LRR_8	106..165	CDD:316378	18/58 (31%)
		LRR 3	106..127		6/20 (30%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		LRR 4	130..151		5/20 (25%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		LRR_5	146..276	CDD:331043	39/131 (30%)
		LRR 5	154..175		6/20 (30%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		LRR 6	178..199		8/21 (38%)
		leucine-rich repeat	179..202	CDD:275380	9/23 (39%)
		LRR 7	202..223		7/20 (35%)
		leucine-rich repeat	203..250	CDD:275380	13/47 (28%)
		LRR 8	226..247		3/20 (15%)
		LRR_8	250..309	CDD:316378	21/59 (36%)
		LRR 9	250..271		6/20 (30%)
		leucine-rich repeat	251..274	CDD:275380	7/22 (32%)
		LRR 10	274..295		7/20 (35%)
		leucine-rich repeat	275..298	CDD:275380	9/22 (41%)
		LRR_8	298..357	CDD:316378	26/83 (31%)
		LRR 11	298..319		9/21 (43%)
		leucine-rich repeat	299..322	CDD:275380	10/23 (43%)
		LRR 12	322..343		9/37 (24%)
		leucine-rich repeat	323..343	CDD:275380	9/36 (25%)
		PCC	327..>391	CDD:188093	28/90 (31%)
		I-set	410..500	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8524
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5661
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940