DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and LRRC53

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001369209.1	Gene:	LRRC53 / 105378803	HGNCID:	25255	Length:	1247	Species:	Homo sapiens

Alignment Length:	655	Identity:	139/655 - (21%)
Similarity:	206/655 - (31%)	Gaps:	219/655 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 TISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVP- 207
            |..||.:....::.:|....|.:..||.|:|.:|.|..:...||.||..||.|.|:.|.:::..
Human    34 TTRVLIITDGYLSSIESTNLSLLFNLALLSLSRNGIEDVQEDALHGLTMLRTLLLEHNQISSSSL 98

  Fly   208 GELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKG--LVSLRFLD 270
            .:.||..||||..|.|..|:..|:.|..|::..|||||.|.|..:.|::..:..|  |.|||:||
Human    99 TDHTFSKLHSLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQITNLTDSSFGGTNLHSLRYLD 163

  Fly   271 LSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSG 335
            ||:|.:..|...||:
Human   164 LSNNFISYIGKDAFR-------------------------------------------------- 178

  Fly   336 NTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFECD 400
                                    .||.|..|.|..|:|:.:.:...|...|..|.|.:|.:.|.
Human   179 ------------------------PLPQLQEVDLSRNRLAHMPDVFTPLKQLILLSLDKNQWSCT 219

  Fly   401 CRL----LWLRHLLVS-----RNASG-QYAPVICAYPTALRDLPLAHL---------------AE 440
            |.|    .:||:.:.|     |||.. ...|...|...|...|.|:..               ..
Human   220 CDLHPLARFLRNYIKSSAHTLRNAKDLNCQPSTAAVAAAQSVLRLSETNCDSKAPNFTLVLKDRS 284

  Fly   441 PLLGCAHGAASKQAIIGILVVACAALITTLALVLYT----------------CRHRIREMLKGHS 489
            |||     .....|::.:|..|.|..:|.|.||::.                |.....|.|..|.
Human   285 PLL-----PGPDVALLTVLGFAGAVGLTCLGLVVFNWKLHQGKANEHTSENLCCRTFDEPLCAHE 344

  Fly   490 ALGRKEREYQKTFSDEEYMSRPPPGGGGVHPAAGG---YPYIAGNSRMIPVTELXLEAPPPPQLR 551
            |.....:.|......:|...:       |....|.   .|.:..||....
Human   345 ARNYHTKGYCNCHLTQENEIK-------VMSTVGSRKEMPLLQENSHQAT--------------- 387

  Fly   552 GRGGGGGASTASGAVQQLQVPSAVDQASNSFAQLSHIHYMTNNGQQQQAQQQQSTSKMHHSQQDM 616
               ....::|..|:.:.|:.... ...|..|.|         :|:...::..:....|....:..
Human   388 ---SASESATLDGSFRNLKKKDR-GVGSTLFCQ---------DGRLLHSECSEPPGNMRAFNEAG 439

  Fly   617 RLLACNGGKPLNATSLPRHRPPVVQESTLSHY---SQPLANGI-------------------RLT 659
            .|...|   |.....|....|..||..||.|:   ::.:::.|                   |||
Human   440 LLTTYN---PRKVQKLWNLEPGEVQPQTLQHHIIRTEDISSDIFRRRYATPASALAGESLEKRLT 501

  Fly   660 ----------QDHFNHNQNQSH------------NQHY--------GGVYAKPCDAM--SEPGYI 692
                      :|:..|...|.|            .:||        ...|..||..:  |:|.|.
Human   502 NESWQPPIEKEDNGLHPHRQRHFITSSSSKPCEPEEHYVQKIVQKNRSKYDDPCGLLKQSKPRYF 566

  Fly   693 H-NNS 696
            . |||
Human   567 QPNNS 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380
		LRR_8	96..155	CDD:290566	3/10 (30%)
		leucine-rich repeat	97..120	CDD:275380
		leucine-rich repeat	121..144	CDD:275380	139/655 (21%)
		LRR_8	143..201	CDD:290566	19/56 (34%)
		leucine-rich repeat	145..168	CDD:275380	4/22 (18%)
		LRR_RI	147..397	CDD:238064	64/252 (25%)
		leucine-rich repeat	169..192	CDD:275380	10/22 (45%)
		leucine-rich repeat	193..217	CDD:275380	8/24 (33%)
		LRR_8	217..276	CDD:290566	26/60 (43%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	9/24 (38%)
		LRR_8	265..321	CDD:290566	11/55 (20%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	0/22 (0%)
		LRR_8	312..374	CDD:290566	6/61 (10%)
		leucine-rich repeat	314..335	CDD:275380	0/20 (0%)
		leucine-rich repeat	339..363	CDD:275380	1/23 (4%)
		LRRCT	395..445	CDD:214507	18/74 (24%)
LRRC53	NP_001369209.1	LRR 1	34..55		4/20 (20%)
		LRR 2	58..79		8/20 (40%)
		LRR 3	82..102		5/19 (26%)
		LRR_8	83..143	CDD:404697	24/59 (41%)
		leucine-rich repeat	83..108	CDD:275380	8/24 (33%)
		LRR 4	108..129		8/20 (40%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		LRR_8	131..193	CDD:404697	27/135 (20%)
		LRR 5	132..153		8/20 (40%)
		leucine-rich repeat	133..158	CDD:275380	9/24 (38%)
		LRR 6	158..179		11/94 (12%)
		leucine-rich repeat	159..182	CDD:275380	11/96 (11%)
		LRR 7	182..203		5/20 (25%)
		leucine-rich repeat	183..205	CDD:275380	6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	828..866
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1247
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160237
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930