DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and lrrn3a

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	XP_005163128.1	Gene:	lrrn3a / 101887059	ZFINID:	ZDB-GENE-061220-7	Length:	691	Species:	Danio rerio

Alignment Length:	697	Identity:	165/697 - (23%)
Similarity:	260/697 - (37%)	Gaps:	134/697 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LCLCLCLVLATLPVALGLAN----------CPNGCECD-----------DDTLMVNCGEGTLDVL 66
            |...:||:     ..|.|.|          |...|:|:           ::...|:|.:..|..|
Zfish     4 LLFAVCLL-----AGLALTNSVQASKWSVVCLKLCKCEIRPWFSPLSMYNEAPTVDCNDLGLLTL 63

  Fly    67 PIALNPAIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKI 131
            |..|....|.|:.:.|.:..|||.:.:...||.:|||.|::.::.:....:..:|..|||:.|.:
Zfish    64 PERLPSDTQVLLSQANSIAKIDSPLDYLVNLTEVDLSRNNISSLSDIYIGHIPQLLSLHLEENWL 128

  Fly   132 GQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVL 196
            .                :|..|.:|...        .|.||.:..|.:|.|...|..||:.|..|
Zfish   129 S----------------SLHDNFLAHFP--------NLQELYVNHNLLSLISAEAFQGLNKLLRL 169

  Fly   197 YLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALK 261
            :|:.|.|..:..| .||.|..|..|.:|.|....|....|:.|..|..|.|....|..|...||.
Zfish   170 HLNSNQLRAIRSE-WFQDLSQLEILMIGENPIARIQNMNFKPLINLRSLVLTRMNLTEIPDSALV 233

  Fly   262 GLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLR 326
            ||..|..:...||..|.:|.||.:::..|:.|::.:|..|.|..|.|..:..|:.|.:.....|.
Zfish   234 GLDKLESVSFYDNMFPKVPQAALRQVRNLKFLDLNKNPIERIQRGDFVDMIHLKELGINSMPELV 298

  Fly   327 RVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLD----EGLVPWADL 387
            .::|.|......|..:..::|.:|:.:...|...||.|.:::|.:|.|.:|.    |.|   .:|
Zfish   299 SIDSFALHNLPELTKIEATNNPRLSYIHPNAFSQLPRLESLMLNSNALRALHHITVESL---PNL 360

  Fly   388 QTLDLSENPFECDCRLLWLRHLLVSRNASGQYAPVICAYPTALRDLPLAHLAEPLLGCAHGAASK 452
            |.:.:..||..|||.:.|: ::..:|....:...::||.|:..                .|...|
Zfish   361 QEVSIHSNPIYCDCVIRWI-NMNNTRVRFMELDALLCAGPSEF----------------EGRLVK 408

  Fly   453 QAIIGILVVACAALIT-----------TLALVLYTCRHRIREMLKGHSALGRKERE-YQKTFSDE 505
            |.....:...|..||:           |..||...||           |....|.| |..|.|.|
Zfish   409 QVHSREMADICLPLISPESLPDQVNVGTGHLVSLHCR-----------AFADPEPEIYWVTPSGE 462

  Fly   506 EYMSRPPPGGGGVHP------------AAGGYPYIAGNSRMIPVTELXLEAPPPPQLRGRGGGGG 558
            :.:.:.......:||            .||.|..:|.|...:.:..:.:
Zfish   463 KILPQMDSKKYHLHPEGTFDIYGITENEAGQYTCVAHNLIGVDMRSVLV---------------- 511

  Fly   559 ASTASGAVQQLQVPSAVDQASNSFAQLSHIHYMTNNGQQQQAQQQQSTSKMHHSQQDMRLLACNG 623
              ..:|....|...|...|..|:......|.::...| ...:..:.||:..|||.|....:..|.
Zfish   512 --IVNGYYPLLVNESLHIQVENTEPNSVSISWVPPKG-SLVSNIKWSTNSQHHSLQFTSHVVSNV 573

  Fly   624 GK--PLNATSLPRHRPPVVQESTLSHYSQPLANGIRLTQDHFNHNQN 668
            .|  ..|..||.::.  |..|.| ...|:.|.|.|.:|....:..:|
Zfish   574 KKFYLTNLHSLTQYE--VCVEIT-DMQSRHLKNCINVTTTEVSKRKN 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	6/20 (30%)
		LRR_8	96..155	CDD:290566	13/58 (22%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	5/22 (23%)
		LRR_8	143..201	CDD:290566	15/57 (26%)
		leucine-rich repeat	145..168	CDD:275380	3/22 (14%)
		LRR_RI	147..397	CDD:238064	72/253 (28%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		leucine-rich repeat	193..217	CDD:275380	9/23 (39%)
		LRR_8	217..276	CDD:290566	19/58 (33%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	9/22 (41%)
		LRR_8	265..321	CDD:290566	16/55 (29%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		LRR_8	312..374	CDD:290566	14/61 (23%)
		leucine-rich repeat	314..335	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	10/49 (20%)
lrrn3a	XP_005163128.1	LRR_RI	29..>272	CDD:238064	73/267 (27%)
		leucine-rich repeat	52..70	CDD:275380	6/17 (35%)
		leucine-rich repeat	71..93	CDD:275380	6/21 (29%)
		leucine-rich repeat	94..117	CDD:275380	6/22 (27%)
		leucine-rich repeat	118..141	CDD:275380	8/46 (17%)
		LRR_8	140..200	CDD:290566	22/68 (32%)
		leucine-rich repeat	142..165	CDD:275380	9/22 (41%)
		leucine-rich repeat	166..189	CDD:275380	9/23 (39%)
		leucine-rich repeat	190..213	CDD:275380	7/22 (32%)
		LRR_8	213..272	CDD:290566	19/58 (33%)
		leucine-rich repeat	214..237	CDD:275380	9/22 (41%)
		leucine-rich repeat	238..261	CDD:275380	7/22 (32%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		leucine-rich repeat	286..310	CDD:275380	5/23 (22%)
		LRR_8	309..370	CDD:290566	16/63 (25%)
		leucine-rich repeat	311..333	CDD:275380	4/21 (19%)
		leucine-rich repeat	336..359	CDD:275378	7/25 (28%)
		leucine-rich repeat	360..372	CDD:275378	4/11 (36%)
		LRRCT	368..412	CDD:214507	13/60 (22%)
		IG_like	429..513	CDD:214653	19/112 (17%)
		Ig	437..513	CDD:299845	18/104 (17%)
		FN3	526..>591	CDD:238020	16/67 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	157	1.000	Inparanoid score	I4248
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	1	0.900	-	-		OOG6_103993
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.860