DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and lingo3

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	XP_004911049.2	Gene:	lingo3 / 100497438	XenbaseID:	XB-GENE-6051175	Length:	605	Species:	Xenopus tropicalis

Alignment Length:	437	Identity:	132/437 - (30%)
Similarity:	198/437 - (45%)	Gaps:	57/437 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FSLCLCLCLCL-----VLATLPVALGLANCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLV 78
            ||:.:.|.|.|     ||          .||..|:|..:...|.|....|..:|..:....:.|.
Frog    11 FSIVVFLLLLLYPEWKVL----------GCPARCDCTPNQRSVICHRKRLTTIPEGIPSETRLLD 65

  Fly    79 IKNNKLKTID-SSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGL 142
            :..|:::.:: .....|:.|..:|||.|.:.||...:||....||.|.|..|::..:....|..|
Frog    66 LSKNRIRCLNPGDFSPYSLLEEVDLSENIISTIEPGAFANLFFLQILKLKGNQLKLIPTGVFTKL 130

  Fly   143 STISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTV- 206
            |.:::|::..|.|..|....|..:..|..|.:|.|.:.:|...|..||.:|..|.::...||::
Frog   131 SNLTLLDISENKIVILLDFMFQDLRSLKSLEVGDNDLLYISQKAFYGLVSLDQLTIEKCNLTSIS 195

  Fly   207 PGELTF-QALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRG-AGLHNISGDALKGLVSLRFL 269
            |..|:: |.|..|...|||.||   :....||.|..|..|:|.. ..|.::...|.:|| :|..|
Frog   196 PESLSYLQGLEVLRLRYLGINS---LEEQNFQKLYNLKELELESWPLLEDVCNTAFQGL-NLTSL 256

  Fly   270 DLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFS 334
            .::...|.::|:||.:.:..||.||:..|...:|..|||..|..||.|.:.|| .|..|||.||.
Frog   257 SITYTNLTSVPSAALRNMVYLEYLNLSFNPIRIIQRGAFKDLVRLRELHIVGA-FLSTVESQAFL 320

  Fly   335 GNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWAD-LQTLDLSENPFE 398
            |...:..||:|:                         |.|::|:|......: |:||.:.:||..
Frog   321 GLRQIRLLNVSN-------------------------NLLATLEESAFQSVNTLETLRVDDNPLA 360

  Fly   399 CDCRLLWLRHLLVSRNASGQYAPVICAYP-----TALRDLPLAHLAE 440
            |||||||:.....:.|.. .:.|| ||.|     .||||.|.:.|.|
Frog   361 CDCRLLWILQRRKTLNFD-NHQPV-CASPAKIQGNALRDFPDSILFE 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	3/21 (14%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_8	143..201	CDD:290566	16/57 (28%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_RI	147..397	CDD:238064	76/253 (30%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..217	CDD:275380	8/25 (32%)
		LRR_8	217..276	CDD:290566	18/59 (31%)
		leucine-rich repeat	218..241	CDD:275380	9/22 (41%)
		leucine-rich repeat	242..265	CDD:275380	7/23 (30%)
		LRR_8	265..321	CDD:290566	19/55 (35%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	10/22 (45%)
		LRR_8	312..374	CDD:290566	16/61 (26%)
		leucine-rich repeat	314..335	CDD:275380	11/20 (55%)
		leucine-rich repeat	339..363	CDD:275380	3/23 (13%)
		LRRCT	395..445	CDD:214507	22/51 (43%)
lingo3	XP_004911049.2	LRR	41..359	CDD:227223	100/347 (29%)
		leucine-rich repeat	61..84	CDD:275380	3/22 (14%)
		leucine-rich repeat	85..108	CDD:275380	9/22 (41%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		leucine-rich repeat	133..156	CDD:275380	5/22 (23%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		leucine-rich repeat	181..204	CDD:275380	6/22 (27%)
		leucine-rich repeat	205..228	CDD:275380	10/25 (40%)
		leucine-rich repeat	229..252	CDD:275380	7/23 (30%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..298	CDD:275380	9/20 (45%)
		leucine-rich repeat	301..324	CDD:275380	12/23 (52%)
		leucine-rich repeat	325..345	CDD:275380	7/44 (16%)
		PCC	329..>399	CDD:188093	28/96 (29%)
		Ig	413..502	CDD:416386
		Ig strand A'	419..423	CDD:409353
		Ig strand B	429..438	CDD:409353
		Ig strand C	443..448	CDD:409353
		Ig strand C'	451..453	CDD:409353
		Ig strand D	462..465	CDD:409353
		Ig strand E	468..475	CDD:409353
		Ig strand F	481..489	CDD:409353
		Ig strand G	492..502	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14097
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910