DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and lingo2

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	XP_004910881.1	Gene:	lingo2 / 100490134	XenbaseID:	XB-GENE-922286	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	518	Identity:	152/518 - (29%)
Similarity:	230/518 - (44%)	Gaps:	71/518 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LCLVLATLPVALGLA-NCPNGCECDDDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSS 90
            |||| |.|.|.:|.| .||..|||......|:|....|..:|..:....:.|.:..||||:: :.
Frog    16 LCLV-AMLLVFMGSAFGCPAKCECSAQNKSVSCHRRRLVTIPEGIPIETKILDLSKNKLKSV-NP 78

  Fly    91 MQF--YAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGN 153
            :.|  |..|..:|||.|.:..:...:|.....|:.|.|..|::..|....|.|||.::.|::..|
Frog    79 VDFVSYPLLEDIDLSDNIISNVEPGAFNSLFNLRSLSLKGNRLKLVPLGVFTGLSNLTKLDISEN 143

  Fly   154 LIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSL 218
            .|..|....|..:..|..|.:|.|.:.:|...|..||.:|..|.|:...||.||.: ....||:|
Frog   144 KIVILLDYMFQDLHSLKSLEVGDNELVYISHRAFSGLVSLEQLTLEKCNLTAVPTD-ALSHLHNL 207

  Fly   219 AELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHN-ISGDALKGLVSLRFLDLSDNRLPAIPTA 282
            ..|:|...:...:|..||:.|..|..|::....|.: :..::|.|| :|.||.:::..|..||..
Frog   208 YSLHLKYLNINVLPPFAFKRLFHLKILEISYWPLLDLVPANSLYGL-NLTFLSITNTNLSTIPYH 271

  Fly   283 AFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSN 347
            |.:.|..|..||:..|...:|.:|.||.|..|:.|.|.||| ||.:|..||.|...|..||:|.|
Frog   272 ALKHLIYLTHLNLSYNPIGIIDTGVFSDLVRLQELHLVGAQ-LRTIEPHAFQGLRFLRLLNVSQN 335

  Fly   348 KQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFECDCRLLWL--RHLL 410
            .               |.|  |:.|...|      |.| |:.|.:.:||..|||||:|:  ||.:
Frog   336 L---------------LET--LEENAFQS------PKA-LEVLCIDDNPLVCDCRLIWMLQRHPM 376

  Fly   411 VSRNASGQYAPVICAYPTALRDLPLAHLAEPLLGCAHGAASKQAIIGILVVACAALITTLALVLY 475
            :  :..||..  :|:.|.:|::                  |...::...|::          ..:
Frog   377 L--HFGGQQP--MCSSPDSLKE------------------SSYKVLDAAVLS----------FYF 409

  Fly   476 TCRH---RIREMLKGHSALGRKEREYQKTFSDEEYM-SRPPPGGGGVHPAAGGYPYIAGNSRM 534
            ||:.   |.||||:.|...|::.:.......|.:.| |...|....|...:.|...:.||..:
Frog   410 TCKKPKIRDREMLQVHVDEGQRVQMNCNADGDPQPMISWVTPRRRTVSLKSNGRTTVLGNGTL 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	7/22 (32%)
		LRR_8	96..155	CDD:290566	17/58 (29%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_8	143..201	CDD:290566	17/57 (30%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_RI	147..397	CDD:238064	79/250 (32%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..217	CDD:275380	8/23 (35%)
		LRR_8	217..276	CDD:290566	16/59 (27%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	6/23 (26%)
		LRR_8	265..321	CDD:290566	20/55 (36%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		LRR_8	312..374	CDD:290566	21/61 (34%)
		leucine-rich repeat	314..335	CDD:275380	11/20 (55%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	15/51 (29%)
lingo2	XP_004910881.1	LRRNT	31..64	CDD:214470	9/32 (28%)
		leucine-rich repeat	43..61	CDD:275380	4/17 (24%)
		leucine-rich repeat	63..86	CDD:275380	7/23 (30%)
		internalin_A	<66..>285	CDD:380193	68/221 (31%)
		leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		leucine-rich repeat	135..158	CDD:275380	5/22 (23%)
		leucine-rich repeat	159..182	CDD:275380	8/22 (36%)
		leucine-rich repeat	183..206	CDD:275380	8/23 (35%)
		leucine-rich repeat	207..254	CDD:275380	13/47 (28%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		LRR_8	279..337	CDD:338972	26/73 (36%)
		leucine-rich repeat	279..302	CDD:275380	9/22 (41%)
		leucine-rich repeat	303..326	CDD:275380	12/23 (52%)
		leucine-rich repeat	327..347	CDD:275380	9/36 (25%)
		TPKR_C2	359..402	CDD:387596	16/64 (25%)
		Ig	429..504	CDD:386229	9/44 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9420
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000