DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and si:ch211-180f4.1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001373634.1	Gene:	si:ch211-180f4.1 / 100144405	ZFINID:	ZDB-GENE-080327-27	Length:	744	Species:	Danio rerio

Alignment Length:	497	Identity:	138/497 - (27%)
Similarity:	207/497 - (41%)	Gaps:	81/497 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RRAITMSLAPHLGQAFSLCLCLCLCLVLATLPVALGLANCPNGCECD-----------DDTLMVN 57
            |.||:.||             |.:|||||....:|.:..||..|.|:           .....|:
Zfish     3 RTAISTSL-------------LTVCLVLAVCRCSLAVPFCPAQCVCETRPWYTPQSVYHQAKTVD 54

  Fly    58 CGEGTLDVLPIALNPAIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQ 122
            |.|..|..:|..::...|.|::::|.:....|.:|....||.||||.|           :..::.
Zfish    55 CNELHLSRIPWNISVDTQVLLLQSNNISRGTSQLQSLVNLTELDLSQN-----------HFTQIH 108

  Fly   123 ELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHAL 187
            ::.|::             |:.:..|.|..|.|.||.......:|.|.||.:..|:||.|.|:|.
Zfish   109 DVGLNN-------------LTQLVTLYLEENQIKELPDMCLKDLVSLEELYINHNQISSIGPNAF 160

  Fly   188 DGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGL 252
            .||.||..|:|:.|.|..:... .|::|.:|..|.:|.|..:.:....|..|..|..|.|.|.||
Zfish   161 SGLGNLLRLHLNSNKLVAIDSH-WFESLPNLEILMIGENPILGLQDMNFHPLTKLHSLVLAGMGL 224

  Fly   253 HNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHL 317
            ..|...|.:||..|..|...||:|.|:|..|.:.|..|:.|::.:|....|..|.|.....|..|
Zfish   225 REIPEGAFQGLEYLESLSFFDNKLTAVPKKALRVLPSLKFLDLNKNPIVRIQEGDFQDFPHLEEL 289

  Fly   318 ELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLV 382
            .|...:.|..||.|:||....:..|.|.:|..|..:...|...:..|.|:::..|.|:.|...:|
Zfish   290 SLNNMEELVAVERGSFSNLPQMAKLELYNNPHLFFIDRAAFLKMRGLRTLLIHNNDLTLLPHEIV 354

  Fly   383 -PWADLQTLDLSENPFECDCRLLWLRHLLVSRNASGQYAP--VICAYP-----TALRD------- 432
             .:.:|..:.|..||..|||...| ..:|.::::.....|  .:||.|     .||:|
Zfish   355 SAFPNLDEISLHSNPLRCDCLNNW-GPVLGNQSSLKVLEPQITLCASPQHLVGQALQDVVSASWN 418

  Fly   433 ------LPL--AHLAEPLLGCAHGAASKQAIIGILVVACAAL 466
                  |||  .|...|.|....|.        :|.:.|.|:
Zfish   419 GASNTCLPLISQHAFPPQLNVTLGQ--------LLTLDCWAV 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	5/20 (25%)
		LRR_8	96..155	CDD:290566	12/58 (21%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	2/22 (9%)
		LRR_8	143..201	CDD:290566	22/57 (39%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	80/250 (32%)
		leucine-rich repeat	169..192	CDD:275380	11/22 (50%)
		leucine-rich repeat	193..217	CDD:275380	7/23 (30%)
		LRR_8	217..276	CDD:290566	20/58 (34%)
		leucine-rich repeat	218..241	CDD:275380	6/22 (27%)
		leucine-rich repeat	242..265	CDD:275380	10/22 (45%)
		LRR_8	265..321	CDD:290566	18/55 (33%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	17/61 (28%)
		leucine-rich repeat	314..335	CDD:275380	8/20 (40%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	20/71 (28%)
si:ch211-180f4.1	NP_001373634.1	leucine-rich repeat	51..70	CDD:275380	5/18 (28%)
		PPP1R42	55..266	CDD:411060	70/235 (30%)
		leucine-rich repeat	71..93	CDD:275380	5/21 (24%)
		leucine-rich repeat	94..117	CDD:275380	9/46 (20%)
		leucine-rich repeat	118..141	CDD:275380	6/22 (27%)
		leucine-rich repeat	142..165	CDD:275380	11/22 (50%)
		leucine-rich repeat	166..189	CDD:275380	7/23 (30%)
		leucine-rich repeat	190..213	CDD:275380	6/22 (27%)
		leucine-rich repeat	214..237	CDD:275380	10/22 (45%)
		leucine-rich repeat	238..261	CDD:275380	9/22 (41%)
		LRR_8	260..320	CDD:404697	17/59 (29%)
		leucine-rich repeat	262..285	CDD:275380	6/22 (27%)
		leucine-rich repeat	286..310	CDD:275380	9/23 (39%)
		leucine-rich repeat	311..330	CDD:275380	4/18 (22%)
		leucine-rich repeat	336..359	CDD:275378	6/22 (27%)
		PCC	341..>412	CDD:188093	19/71 (27%)
		leucine-rich repeat	360..372	CDD:275378	4/11 (36%)
		IG	434..528	CDD:214652	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	157	1.000	Inparanoid score	I4248
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	1	0.900	-	-		OOG6_103993
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.860