DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and flrt1b

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	XP_005169675.1	Gene:	flrt1b / 100144397	ZFINID:	ZDB-GENE-080327-6	Length:	715	Species:	Danio rerio

Alignment Length:	870	Identity:	199/870 - (22%)
Similarity:	283/870 - (32%)	Gaps:	276/870 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TMSLAPHLGQAFSLCLCLCLCL--------VLATLPVALGLAN------CPNGCECDDDTLMVNC 58
            |.||.......|.|.|||.|.:        ..|....|||.|.      ||:.|.|||.  .:.|
Zfish     3 TESLVELRDWLFLLLLCLTLLVEVLEFAAATAAAAEAALGEAELQGEVPCPSACRCDDG--FIYC 65

  Fly    59 GEGTLDVL-PIALNPAIQRLVIKNNKLKTIDSSMQFYAQLTF----------------------- 99
            .:..|.:: |:.|..|:  |.::||::...........:||.
Zfish    66 NDRGLTLIPPLPLTAAV--LYLQNNRIDNAGLPTSLERRLTVRVVYLYDNELDDFPTHLPPSLRE 128

  Fly   100 LDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVS--NKTFLGLSTISVLNLRGNLIAELEYRT 162
            |.|..|::.|:|..:.|....|::||:|.|.|..||  :|.|.....:.:|.|..|.::.:
Zfish   129 LHLQDNNIRTLPRSALARLPLLEKLHMDDNSISTVSIEDKAFTNNPRLRLLFLSRNHLSSI---- 189

  Fly   163 FSPM---VKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVP-GELTFQALHSLAELYL 223
              |.   ..|.||.|..||||.|..||..||.:||.|:||.|.|.... .:.||..|.:|.||.|
Zfish   190 --PSGLPASLEELRLDDNRISTIPTHAFRGLSSLRRLFLDGNLLANQRIADDTFSRLSNLTELSL 252

  Fly   224 GTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLG 288
            ..||....|              |....||            |..|.|.||.:..:|..:...:.
Zfish   253 VRNSLQAPP--------------LNLPSLH------------LLRLYLQDNAIAHMPRGSLDGMR 291

  Fly   289 RLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNEL 353
            ||::|:|..|:...:..|.|                                       |.|:.|
Zfish   292 RLQKLDISGNNLTTLPRGLF---------------------------------------KDLDSL 317

  Fly   354 SSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLSENPFECDCRLLWLRHLLVSRNASGQ 418
            |.:.:.|                                  ||:.|.|.|.||...|..|.:|..
Zfish   318 SQLLVRG----------------------------------NPWYCGCNLRWLHDWLHERGSSVT 348

  Fly   419 YAPVICAYPTALRDLPLAHLAEPLLGCAHGAASKQAIIGILVV--------ACAALITTLAL--- 472
            ...:.|..|..||.:.|..|:..|..|.....:...::|..|.        ......||..|
Zfish   349 VRGLTCHAPERLRGMALRDLSSQLEDCEVTVDAAGGMVGNEVAKKEKGYFPTQPPATTTPPLPQG 413

  Fly   473 VLYTCRHRIREMLKGHSALGRKEREYQKTFSDEEYMSRPPPGGGGVHPAAGGYPYIAGNSRMIPV 537
            .|:|.|.|    ..||.            :||   |.:...|||      .|:   ...|.:|.|
Zfish   414 SLFTLRSR----RPGHK------------YSD---MGQDSLGGG------NGF---VSKSLLISV 450

  Fly   538 TELXLE--------APPPPQLRGRGGGGGASTASGAVQQLQVPS-------------------AV 575
            ..| .|        |.|.|..|......|.|.|.|::.:..||.                   .|
Zfish   451 KPLTPETVHITWQAAQPVPSFRLSWLRLGNSPAMGSITETLVPGDRREYLLTQLQPQSSYIICLV 515

  Fly   576 DQASN-----SFAQLSHIHYMTNNGQQQQAQQQQSTSKMHH--SQQDMRLLACNGGKPLNATSLP 633
            ..|.|     ||.....::..||:..:..|..:..|..:..  |.||    :..|...|:|..|
Zfish   516 PLAGNDGKRTSFTATGGLNINTNSEHEHPACAKTETDPLEQPMSDQD----SDRGTDALSALPL- 575

  Fly   634 RHRPPVVQEST--------------LSHYSQPLANGIRLTQDHFNHNQ----NQSHNQHYGGVYA 680
               ..::..:|              ..|.:..||.|     ||..:.:    ::..::||
Zfish   576 ---AGIIGGATALVSLFLIFGIFCWYGHRAGYLAPG-----DHSIYGRDVVGSRDASKHY----- 627

  Fly   681 KPCDAMSEPGYIHNNSHYSLPLDHDLPPSPTPTPPPPALPLRNGVGMALIHGNTTGRRSFNNNNN 745
               |...|.|.|.:.|...:.. |....:|. :...|..|......|..||      ..|.:||.
Zfish   628 ---DDYVESGTIKDTSILEIRA-HGFQMTPM-SAQQPLQPKAKVEDMTYIH------TIFPSNNA 681

  Fly   746 V---STLSNNNHHGIGGGVGVAVGG 767
            .   |||::..:...|...|...||
Zfish   682 TLYRSTLNHTGNPSYGTNRGYREGG 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	3/20 (15%)
		LRR_8	96..155	CDD:290566	21/83 (25%)
		leucine-rich repeat	97..120	CDD:275380	8/45 (18%)
		leucine-rich repeat	121..144	CDD:275380	10/24 (42%)
		LRR_8	143..201	CDD:290566	22/60 (37%)
		leucine-rich repeat	145..168	CDD:275380	4/25 (16%)
		LRR_RI	147..397	CDD:238064	56/253 (22%)
		leucine-rich repeat	169..192	CDD:275380	13/22 (59%)
		leucine-rich repeat	193..217	CDD:275380	10/24 (42%)
		LRR_8	217..276	CDD:290566	15/58 (26%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	3/22 (14%)
		LRR_8	265..321	CDD:290566	13/55 (24%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	5/61 (8%)
		leucine-rich repeat	314..335	CDD:275380	0/20 (0%)
		leucine-rich repeat	339..363	CDD:275380	5/23 (22%)
		LRRCT	395..445	CDD:214507	17/49 (35%)
flrt1b	XP_005169675.1	LRRNT	51..77	CDD:214470	9/27 (33%)
		leucine-rich repeat	82..104	CDD:275378	3/23 (13%)
		leucine-rich repeat	105..125	CDD:275380	0/19 (0%)
		LRR_RI	<120..305	CDD:238064	64/216 (30%)
		LRR_8	124..186	CDD:290566	19/61 (31%)
		leucine-rich repeat	126..149	CDD:275380	6/22 (27%)
		leucine-rich repeat	150..175	CDD:275380	10/24 (42%)
		LRR_8	174..231	CDD:290566	23/62 (37%)
		leucine-rich repeat	176..196	CDD:275380	4/25 (16%)
		leucine-rich repeat	197..220	CDD:275380	13/22 (59%)
		leucine-rich repeat	221..246	CDD:275380	10/24 (42%)
		leucine-rich repeat	247..268	CDD:275380	8/34 (24%)
		LRR_8	268..326	CDD:290566	19/142 (13%)
		leucine-rich repeat	269..292	CDD:275380	6/22 (27%)
		leucine-rich repeat	293..316	CDD:275380	8/61 (13%)
		LRRCT	325..375	CDD:214507	17/49 (35%)
		fn3	448..515	CDD:278470	14/66 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	1	0.960