DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caps and lrrn1-like

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001106456.1	Gene:	lrrn1-like / 100127637	XenbaseID:	XB-GENE-492890	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	710	Identity:	169/710 - (23%)
Similarity:	273/710 - (38%)	Gaps:	177/710 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 CLCLCLVLATLPVALGLANCPNGCECD-----------DDTLMVNCGEGTLDVLPIALNPAIQRL 77
            ||.:.::.:.....||:  ||..|.|:           .:...|:|.:..|..:|..|:..||.|
Frog    21 CLFVIVLHSVFFSTLGV--CPPQCVCETRPWFTPQSVYHEAKTVDCNDLLLTHIPENLSTDIQVL 83

  Fly    78 VIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGL 142
            ::::||:..:...:|..:.||.||||.|...:|.:...:..::|..|:|:.|::.::.:.:...|
Frog    84 LLQSNKISHLTWELQELSNLTELDLSQNHFQSIDDLGVSNLSQLITLYLEENQLRELPDYSLKDL 148

  Fly   143 STISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVP 207
            .::..|.:..|.|:.:..|.||.:.:|..|:|..||:..|||...:.|.||.:|.:.:|.:|
Frog   149 GSLEELYINHNQISYIGPRAFSGLGRLLRLHLNANRLEIIDPRWFEDLPNLEILMVGENPVT--- 210

  Fly   208 GELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLS 272
                  ||.||                .||.|..|..|.|.|..|.:|..:|.:||..|..|...
Frog   211 ------ALQSL----------------NFQPLGRLHSLVLAGMELEHIPENAFQGLDYLESLSFF 253

  Fly   273 DNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNT 337
            ||||..:|..|.:.|..|:.|::.:|....|..|.|:|:..|..|.|...:.|.|||:.||....
Frog   254 DNRLTEVPKEALKNLKLLKFLDLNKNPIPEIRGGDFTGMEHLEELSLNSMEELERVEAEAFQDLP 318

  Fly   338 NLEHLNLSSNKQLNELSSIAL-GGLPHLSTVVLKANQLSSLDEGLVPWADLQTL------DLSEN 395
            .|..|.:.:|.:|:.|...|. ..|..|.|::|..|:|:     :||....|.|      .|..|
Frog   319 ELIKLEMCNNPRLSYLDPEAFSSNLGALKTLLLNNNRLA-----MVPLKIFQALPGLLEISLYSN 378

  Fly   396 PFECDCRLLW-----LRHLLVSRNASGQYAPVICAYPTALRDLPL--AHLAEPLLGCAHGAASKQ 453
            |..|||:..|     ||  |:...|:      :|..|      ||  .||.:.:.|        |
Frog   379 PIRCDCQNCWKGLSKLR--LIEAQAT------LCINP------PLVSGHLFQEIQG--------Q 421

  Fly   454 AIIGILVVACAALITT--LALVLYTCRH---RIREMLKGHSALGRKEREYQKTFSDEEYMSRPPP 513
            |.:.    .|..||.|  :.......||   ::.....||
Frog   422 AWLN----RCPPLIDTHLIPPQFQIARHQPVKLSCQASGH------------------------- 457

  Fly   514 GGGGVHPAAGGYPYIAGNSRMIPVTELXLEAPPPPQLRGRGG-----GGGASTASGAVQQLQVPS 573
                                  |..|: ...|...::.|..|     .||:         |::..
Frog   458 ----------------------PKPEIYWMTPHGERVTGTNGRVKINAGGS---------LEITD 491

  Fly   574 AVDQASNSF---------AQLSHIHYMTNNGQQQQAQQQQSTSKMHHSQ---QDMRLLACNGGKP 626
            ||::.|.|:         .....:....|..|:.:|......:|..||.   .:.::|:.:|..|
Frog   492 AVEEDSGSYTCQMWNSDGTDSKSVFVSINRTQEPEAMSLLMVTKKVHSNFAVVEWKMLSGSGVSP 556

  Fly   627 -------LNATSLPRHRPPV---------VQESTLSHYSQPLANGIRLTQDHFNHNQNQS 670
                   .::.::..|.|.:         |||..|:|........:.||....:....||
Frog   557 NVLVPFQWSSATMRIHNPHISYTAKVPLEVQEYNLTHLQPSTKYEVCLTVSSVSQPSQQS 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	5/20 (25%)
		LRR_8	96..155	CDD:290566	15/58 (26%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		leucine-rich repeat	121..144	CDD:275380	5/22 (23%)
		LRR_8	143..201	CDD:290566	18/57 (32%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR_RI	147..397	CDD:238064	79/256 (31%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		leucine-rich repeat	193..217	CDD:275380	6/23 (26%)
		LRR_8	217..276	CDD:290566	18/58 (31%)
		leucine-rich repeat	218..241	CDD:275380	4/22 (18%)
		leucine-rich repeat	242..265	CDD:275380	9/22 (41%)
		LRR_8	265..321	CDD:290566	19/55 (35%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		LRR_8	312..374	CDD:290566	20/62 (32%)
		leucine-rich repeat	314..335	CDD:275380	9/20 (45%)
		leucine-rich repeat	339..363	CDD:275380	7/24 (29%)
		LRRCT	395..445	CDD:214507	16/56 (29%)
lrrn1-like	NP_001106456.1	NEL	<52..>262	CDD:330839	66/234 (28%)
		leucine-rich repeat	60..79	CDD:275380	5/18 (28%)
		leucine-rich repeat	80..102	CDD:275380	6/21 (29%)
		LRR_8	101..161	CDD:316378	15/59 (25%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		leucine-rich repeat	127..150	CDD:275380	5/22 (23%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		leucine-rich repeat	175..198	CDD:275380	9/22 (41%)
		leucine-rich repeat	199..222	CDD:275380	11/47 (23%)
		leucine-rich repeat	223..246	CDD:275380	9/22 (41%)
		leucine-rich repeat	247..294	CDD:275380	16/46 (35%)
		LRR_8	294..356	CDD:316378	20/61 (33%)
		leucine-rich repeat	295..319	CDD:275380	9/23 (39%)
		leucine-rich repeat	320..345	CDD:275380	7/24 (29%)
		leucine-rich repeat	346..367	CDD:275380	8/25 (32%)
		PCC	351..>412	CDD:188093	22/79 (28%)
		leucine-rich repeat	370..382	CDD:275378	3/11 (27%)
		Ig	448..515	CDD:319273	14/122 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11458
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4049
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14097
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960