DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caps and lingo1

DIOPT Version :9

Sequence 1:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_001093719.1	Gene:	lingo1 / 100101739	XenbaseID:	XB-GENE-921957	Length:	606	Species:	Xenopus tropicalis

Alignment Length:	530	Identity:	135/530 - (25%)
Similarity:	203/530 - (38%)	Gaps:	135/530 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CLCLCLCLVLATLPVALGLANCPNGCECDDDTLMVNC-GEGTLDVLPIALNPAIQRLVIKNNKLK 85
            |||..|.:|:.:: ::...:.||..|:|......|.| .:..||| |..: |...||
Frog     8 CLCPILLIVVGSI-LSGSASGCPQRCDCSPQDRSVLCHRKRYLDV-PEGI-PTDTRL-------- 61

  Fly    86 TIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNL 150
                          ||||.|.:..:.:..|:....|:||.|:.|.:..:....|.||..:..|.|
Frog    62 --------------LDLSKNRIKALNQDEFSAFPYLEELELNENIVSIIEPGAFNGLFNLRSLGL 112

  Fly   151 RGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQAL 215
            |.|.:..:....|:.:..|.:|::.:|:|..:.......|.||:.|.:.||.|..: ....|:.|
Frog   113 RSNRLKLIPLGVFTGLSNLTQLDISENKIVILLDDMFQDLYNLKSLEVGDNDLVYI-SHRAFRGL 176

  Fly   216 HSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLR--------FLD-- 270
            :||.||.|...:..::|..|...|.||..|.||...::.|...:.|.|..|:        :||
Frog   177 NSLEELTLEKCNLTSVPTEALSHLHGLITLKLRYLNINVIRDYSFKRLYRLKNLEIAHWPYLDTM 241

  Fly   271 --------------LSDNRLPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTG 321
                          ::.:.|.:||..|.:.|..|..||:..|....:.......|..|:...|.|
Frog   242 TSNGLYGLNLTSLSITHSNLSSIPYVAIRHLVYLRFLNLSYNPITAVEGSMLYELLRLQEFHLVG 306

  Fly   322 AQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWAD 386
            .| |..||..||.|..:|:.||:|||               :|||  |:.:...|:       .:
Frog   307 GQ-LSVVEPYAFRGLNHLKVLNVSSN---------------YLST--LEESSFHSV-------GN 346

  Fly   387 LQTLDLSENPFECDCRLLWLRHLLVSRNASGQYAPVICAYP-----TALRDLPLAHLAEPLLGCA 446
            |:||.|.:||..|||||||:.......|.|.|...  |:.|     ...:|.|
Frog   347 LETLILDKNPLACDCRLLWIFRRRWRLNFSRQQPS--CSSPEYVQGKEFKDFP------------ 397

  Fly   447 HGAASKQAIIGILVVACAALITTLALVLYTCRHRIREMLKGHSALGRKEREYQKTFSDE----EY 507
                                 ..|....:|||   |..::.|||        |..:.||    .:
Frog   398 ---------------------DVLQPNYFTCR---RARIQDHSA--------QVVYVDEGHTVHF 430

  Fly   508 MSR----PPP 513
            ..|    |||
Frog   431 FCRADGDPPP 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	2/20 (10%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_8	143..201	CDD:290566	13/57 (23%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		LRR_RI	147..397	CDD:238064	73/273 (27%)
		leucine-rich repeat	169..192	CDD:275380	5/22 (23%)
		leucine-rich repeat	193..217	CDD:275380	7/23 (30%)
		LRR_8	217..276	CDD:290566	19/82 (23%)
		leucine-rich repeat	218..241	CDD:275380	7/22 (32%)
		leucine-rich repeat	242..265	CDD:275380	7/22 (32%)
		LRR_8	265..321	CDD:290566	15/79 (19%)
		leucine-rich repeat	266..289	CDD:275380	8/46 (17%)
		leucine-rich repeat	290..313	CDD:275380	5/22 (23%)
		LRR_8	312..374	CDD:290566	20/61 (33%)
		leucine-rich repeat	314..335	CDD:275380	9/20 (45%)
		leucine-rich repeat	339..363	CDD:275380	6/23 (26%)
		LRRCT	395..445	CDD:214507	16/54 (30%)
lingo1	NP_001093719.1	LRRNT	27..61	CDD:214470	11/35 (31%)
		LRR 1	58..79		8/42 (19%)
		leucine-rich repeat	59..82	CDD:275380	8/44 (18%)
		PLN00113	62..>381	CDD:215061	98/344 (28%)
		LRR 2	82..103		6/20 (30%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		LRR_8	106..165	CDD:338972	15/58 (26%)
		LRR 3	106..127		5/20 (25%)
		leucine-rich repeat	107..130	CDD:275380	5/22 (23%)
		LRR 4	130..151		4/20 (20%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		LRR 5	154..175		7/21 (33%)
		leucine-rich repeat	155..178	CDD:275380	7/23 (30%)
		LRR 6	178..199		7/20 (35%)
		leucine-rich repeat	179..250	CDD:275380	18/70 (26%)
		LRR 7	202..223		6/20 (30%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		LRR 8	250..271		4/20 (20%)
		leucine-rich repeat	251..274	CDD:275380	5/22 (23%)
		LRR 9	274..295		4/20 (20%)
		leucine-rich repeat	275..298	CDD:275380	5/22 (23%)
		LRR 10	298..319		9/21 (43%)
		leucine-rich repeat	299..322	CDD:275380	10/23 (43%)
		LRR 11	322..343		10/37 (27%)
		leucine-rich repeat	323..343	CDD:275380	10/36 (28%)
		Ig	425..500	CDD:386229	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9420
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910