DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snky and spe-42

DIOPT Version :9

Sequence 1:	NP_648633.2	Gene:	snky / 39492	FlyBaseID:	FBgn0086916	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_872213.4	Gene:	spe-42 / 353452	WormBaseID:	WBGene00007117	Length:	774	Species:	Caenorhabditis elegans

Alignment Length:	774	Identity:	154/774 - (19%)
Similarity:	280/774 - (36%)	Gaps:	213/774 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LYGPQSEGSTR---IQCLRRFVTF--LLGLVLGFLL-WKLAALNFTLGRLFVNGATDLYVFIIFV 74
            :|....|..||   |..|.|.:..  |.|:|:.||| :|.:.....:|   .:.:|.::||:||.
Worm    63 IYDNLFEDGTRANSIVLLFRNILMIELFGIVMYFLLSFKYSQYPEFIG---TSISTIIHVFLIFT 124

  Fly    75 LV---TGTIFMLSL------PVRAVILLIFVALVGKSGRTYLRAVAFAFIISGPIANLVENAGEV 130
            |:   ..|.||:|:      .::.:||::.|.:              ||  .||..|::.|..:|
Worm   125 LIFPKMMTYFMISIHVMLTTKIKNIILILLVTM--------------AF--EGPAMNVIGNIHQV 173

  Fly   131 ARVFVCTTVLTYNLSKTRFD----------LMAKPFTNTLKHMRGDVEEIRHTFYELQEVLVDLK 185
            |....|..:   ::..:|.|          ::...|...|:::.|.:.:::.....|.|.:.  |
Worm   174 ASGVACVQI---DVMSSRNDVEGNVMDKGAMLVSRFRALLQNVSGPMNKVKKMLLVLDEKMT--K 233

  Fly   186 YAVENSDIEDEKYGDKNTKPIYERWGRETSRMNVSEIGNGGKELPTPAAVQERFQRNMRNRCKHQ 250
            :.    ||....|                                       |...|:.|:|::.
Worm   234 FV----DIMRRHY---------------------------------------RVIANLSNQCRNM 255

  Fly   251 LRSGHRACLEVFRNGYRKCTTN---FPS------MIAKA--ICWPYRVDIICELDLFGNPDKICD 304
            |::.:..||::|.:.|..|...   |.|      ||.|.  ||...:          |...::|.
Worm   256 LKTPYTKCLDIFDDAYFYCKGKARFFGSHGDACEMIQKTAKICHQAK----------GFSTEVCS 310

  Fly   305 -PS--------AVVPQNFGETYVELLK-AEKKLF---------------------DNSSQIVVNY 338
             ||        |.||  |...|.:.:: |.||:|                     ..:..|...|
Worm   311 LPSIIGKGVKGAAVP--FYAAYFQAIEFAVKKIFYVHIEAAKWALKKVNPVIEEIKKAKNIRAEY 373

  Fly   339 EIKDEQFAKSQLKSAERTGQAFKEDFERQKRIFNKVMGILQKIL--C----------LFMLRMVY 391
            :..|:....:...:......:.|:.......::.:::.|:..||  |          ::.||.:|
Worm   374 QSSDDGKPNAADDTTANLRASIKKSLMGIVNVYIRIINIISFILRYCIMPGLLIWPFIYTLRFMY 438

  Fly   392 VSINYYVKYLNDVEFDNFYITKYFKHVDQRRKEQRIDAILPLRTYEKSKYIDVDHIFSRTHHEST 456
             :.||     || :|.|.::||.|..:||....:....::||...|..:|:.... :..|..|..
Worm   439 -NYNY-----ND-DFKNRFLTKEFTKIDQDCAFRGARKVMPLMANESKQYVSRGQ-WKMTEQERP 495

  Fly   457 TVCFNLLQFLLELVTAGLFILIDHLVVELLQIVR---KRSKIVYQQDGEHEVRFNISGVGQMARL 518
            ....::...::..||.....::|:.:...|..|.   .|:.|    |........::|...|:.:
Worm   496 KFRLDIFITIVSCVTPFFMCMLDYGIFTTLSTVHTLMNRTNI----DTPAHYELKVAGNSSMSDV 556

  Fly   519 LRTTMHNFNIHEKVSTSLSN--KECL--PNAHVLPKKMYYQLILLYLIIIVLIYQSTTFLRMRRV 579
            :...:..|:...|......|  :.|.  ||.....:.|.  :.|:::..:.|......|.|...|
Worm   557 MNEFLDVFSPFTKSIRDRENRWRRCFNEPNPPNYTENMV--MFLMFIAALFLCRLKAYFGRQTLV 619

  Fly   580 ICSFFYYKREKQRILFLYNRILRNRLRSLEFLIHD-------AEDNLATHRIQQQVNVFLWLRFS 637
            :..:|:..|.:.|.|.|||:||::|...|..::.:       .||.:....:|.:       .|.
Worm   620 LADYFFPNRVRIRALSLYNKILQSRRNLLTEMLGNNKKDVVGGEDVIIRRTMQSR-------GFV 677

  Fly   638 CPVAFGWIRHFKFAKRTCMIC-----RGLEDSTFTVCGNCGLPYCDDCAEDLNSVCFQC 691
            |              ..|:.|     :..:.....||.:|...||.:|. .:...|.:|
Worm   678 C--------------SDCVKCEKYDMKVSDQENVRVCVHCSAFYCINCF-SVTLFCVKC 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snky	NP_648633.2	DC_STAMP	406..597	CDD:311636	39/197 (20%)
spe-42	NP_872213.4	DC_STAMP	446..637	CDD:369517	39/197 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167746
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3726
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770