DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Lrrn3

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_110483.2	Gene:	Lrrn3 / 81514	RGDID:	71066	Length:	707	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	128/476 - (26%)
Similarity:	204/476 - (42%)	Gaps:	60/476 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ASIGVEPAAGLA------------NCPPGCQCD-----------DNTLVVQCGEGQLDVLPIALN 58
            |.:.:....|||            :||..|.|:           ...|.|.|.:..|...|..|.
  Rat     4 APLQIHVLLGLAITALVQAGDKKVDCPQLCTCEIRPWFTPRSIYMEALTVDCNDLGLLNFPARLP 68

  Fly    59 PSIQRLVIKSNKIKTIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISN 123
            ...|.|::::|.|..|:.|..|...||.||||.|:|.::.........:|..|:|..||:.::..
  Rat    69 ADTQILLLQTNNIARIEHSTDFPVNLTGLDLSQNNLSSVTNINVQKMSQLLSVYLEENKLTELPE 133

  Fly   124 KTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDN 188
            |...|||.:..|.:..|.:|.:..|.|..|..:..|:|..||:..::.|.|:.|..|.||.|.||
  Rat   134 KCLYGLSNLQELYVNHNLLSAISPGAFVGLHNLLRLHLNSNRLQMINSKWFEALPNLEILMLGDN 198

  Fly   189 ALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQEL 253
            .:..:.|                ||         ||.|..|..|.:.|.:|..:..|:.:||:.|
  Rat   199 PILRIKD----------------MN---------FQPLLKLRSLVIAGINLTEVPGDALVGLENL 238

  Fly   254 RILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTG 318
            ..:...||||:::|.|.|.|.|.|:.|.|.:|....|..|.|..:..||.|.:|....|..:.:.
  Rat   239 ESISFYDNRLNKVPQVALQKAVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELVSIDSL 303

  Fly   319 AFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEG-LFPWKDLQTLDLSEN 382
            |..:..:|..:..::|..|..:...|...|.:|:.::|.:|||::|..| :....:|:.:.:..|
  Rat   304 AVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSN 368

  Fly   383 PLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLR--HLNPAMMGCTHADPRKQALIG 445
            |:.|||.:.|::  :...|....:...|.|..|...:|:::|  |....|..|.       .||.
  Rat   369 PIRCDCVIRWIN--MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICL-------PLIA 424

  Fly   446 ALLVGSAATITALALVLYRCR 466
            .....|...:.|.:.|...||
  Rat   425 PESFPSILDVEADSYVSLHCR 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	6/17 (35%)
		LRR_8	83..142	CDD:290566	19/58 (33%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_RI	129..421	CDD:238064	80/292 (27%)
		LRR_8	132..190	CDD:290566	19/57 (33%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	15/59 (25%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	20/55 (36%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..322	CDD:275380	6/20 (30%)
		LRR_8	325..384	CDD:290566	14/59 (24%)
		leucine-rich repeat	326..350	CDD:275380	5/23 (22%)
		leucine-rich repeat	351..373	CDD:275380	7/22 (32%)
Lrrn3	NP_110483.2	LRRNT	28..72	CDD:214470	10/43 (23%)
		LRR 1	70..91		6/20 (30%)
		LRR	<72..355	CDD:227223	91/307 (30%)
		leucine-rich repeat	72..93	CDD:275380	7/20 (35%)
		LRR 2	93..114		8/20 (40%)
		leucine-rich repeat	94..117	CDD:275380	8/22 (36%)
		LRR 3	117..138		6/20 (30%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		LRR 4	141..162		5/20 (25%)
		leucine-rich repeat	142..165	CDD:275380	6/22 (27%)
		LRR 5	165..186		6/20 (30%)
		leucine-rich repeat	166..189	CDD:275380	7/22 (32%)
		LRR 6	189..210		10/45 (22%)
		leucine-rich repeat	190..213	CDD:275380	12/47 (26%)
		LRR 7	213..234		5/20 (25%)
		leucine-rich repeat	214..237	CDD:275380	7/22 (32%)
		LRR 8	237..258		8/20 (40%)
		leucine-rich repeat	238..261	CDD:275380	9/22 (41%)
		LRR 9	261..282		7/20 (35%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		LRR 10	285..304		5/18 (28%)
		leucine-rich repeat	286..310	CDD:275380	6/23 (26%)
		LRR 11	310..332		4/21 (19%)
		leucine-rich repeat	311..333	CDD:275380	4/21 (19%)
		LRR 12	335..358		7/22 (32%)
		leucine-rich repeat	336..359	CDD:275378	7/22 (32%)
		PCC	341..>405	CDD:188093	17/65 (26%)
		leucine-rich repeat	360..372	CDD:275378	3/11 (27%)
		Ig	440..513	CDD:416386	3/6 (50%)
		Ig strand B	440..447	CDD:409353	3/6 (50%)
		Ig strand C	453..458	CDD:409353
		Ig strand C'	461..464	CDD:409353
		Ig strand D	470..474	CDD:409353
		Ig strand E	479..483	CDD:409353
		Ig strand F	493..500	CDD:409353
		Ig strand G	503..513	CDD:409353
		fn3	526..593	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4127
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8997
orthoMCL	1	0.900	-	-		OOG6_103993
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960