DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and LRRTM4

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001317299.1 Gene:LRRTM4 / 80059 HGNCID:19411 Length:591 Species:Homo sapiens


Alignment Length:602 Identity:138/602 - (22%)
Similarity:216/602 - (35%) Gaps:202/602 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 CPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTFLDLSSNHL 94
            ||..|:||..  :|.|.......:|..::...|.|.::.|.|:.:.|:                 
Human    35 CPKNCRCDGK--IVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSN----------------- 80

  Fly    95 MTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEEL 159
                  .||...:|..::|:||.|..:....|.|:..:..|.|..|:|:.||..||.|:..:..|
Human    81 ------QFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNL 139

  Fly   160 NLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQ 224
            :|..|::..|..:.|.||.:|.||:|..|:|.|||..|                         ||
Human   140 DLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRV-------------------------FQ 179

  Fly   225 DLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEV 289
            |.:.|..|:|....||::|.::|.||.:|:.|.|..|:..:|......:|..|..:.|..|....
Human   180 DCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRS 244

  Fly   290 ISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHV 354
            ||:|.......|..|:::|. .::.:..|.|....||:.|||.|||         |:.:||    
Human   245 ISQGLTWTWSSLHNLDLSGN-DIQGIEPGTFKCLPNLQKLNLDSNK---------LTNISQ---- 295

  Fly   355 VLKANALTSLAEGLFPWKDLQTLDLSENPLSCD---CRVM-WLHNLLVAKNASQDDVSELLCEFP 415
                       |.:..|..|.::.||.|...|.   |.:. ||      ||...:..|.::|..|
Human   296 -----------ETVNAWISLISITLSGNMWECSRSICPLFYWL------KNFKGNKESTMICAGP 343

  Fly   416 ERLRGESL--------------------RHLNPAMMGCTHADPRKQALI---------------- 444
            :.::||.:                    .||.|       ..|:|..:|                
Human   344 KHIQGEKVSDAVETYNICSEVQVVNTERSHLVP-------QTPQKPLIIPRPTIFKPDVTQSTFE 401

  Fly   445 -----------GA-----------LLVGSAATITALALVLY-----------------------R 464
                       ||           ::.||.|...::|::|.                       |
Human   402 TPSPSPGFQIPGAEQEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKR 466

  Fly   465 CRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYT-------- 521
            .|.|.||:.:   ..||.|.....:|:.|          ......:.::.:.|.|||        
Human   467 RRKKARESER---QMNSPLQEYYVDYKPT----------NSETMDISVNGSGPCTYTISGSRECE 518

  Fly   522 APHHPGATHHYGMCPMP 538
            .|||        |.|:|
Human   519 MPHH--------MKPLP 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 5/17 (29%)
LRR_8 83..142 CDD:290566 12/58 (21%)
leucine-rich repeat 84..107 CDD:275380 2/22 (9%)
leucine-rich repeat 108..131 CDD:275380 7/22 (32%)
LRR_RI 129..421 CDD:238064 81/295 (27%)
LRR_8 132..190 CDD:290566 21/57 (37%)
leucine-rich repeat 132..155 CDD:275380 9/22 (41%)
leucine-rich repeat 156..179 CDD:275380 7/22 (32%)
leucine-rich repeat 180..204 CDD:275380 10/23 (43%)
LRR_8 203..263 CDD:290566 16/59 (27%)
leucine-rich repeat 205..228 CDD:275380 3/22 (14%)
leucine-rich repeat 229..252 CDD:275380 9/22 (41%)
LRR_8 252..308 CDD:290566 14/55 (25%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
leucine-rich repeat 277..300 CDD:275380 6/22 (27%)
leucine-rich repeat 301..322 CDD:275380 5/20 (25%)
LRR_8 325..384 CDD:290566 17/58 (29%)
leucine-rich repeat 326..350 CDD:275380 8/23 (35%)
leucine-rich repeat 351..373 CDD:275380 2/21 (10%)
LRRTM4NP_001317299.1 leucine-rich repeat 44..62 CDD:275380 3/19 (16%)
leucine-rich repeat 65..87 CDD:275380 7/44 (16%)
LRR_RI <85..291 CDD:238064 70/240 (29%)
LRR_8 87..146 CDD:290566 19/58 (33%)
leucine-rich repeat 88..111 CDD:275380 7/22 (32%)
leucine-rich repeat 112..135 CDD:275380 9/22 (41%)
LRR_8 134..194 CDD:290566 23/84 (27%)
leucine-rich repeat 136..159 CDD:275380 7/22 (32%)
leucine-rich repeat 160..183 CDD:275380 13/47 (28%)
leucine-rich repeat 184..207 CDD:275380 9/22 (41%)
leucine-rich repeat 208..231 CDD:275380 6/22 (27%)
LRR_8 231..290 CDD:290566 19/68 (28%)
leucine-rich repeat 232..255 CDD:275380 6/22 (27%)
leucine-rich repeat 256..279 CDD:275380 5/23 (22%)
leucine-rich repeat 304..316 CDD:275378 4/11 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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