DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and lrrn3

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001072526.1	Gene:	lrrn3 / 779981	XenbaseID:	XB-GENE-490955	Length:	706	Species:	Xenopus tropicalis

Alignment Length:	633	Identity:	158/633 - (24%)
Similarity:	259/633 - (40%)	Gaps:	117/633 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NCPPGCQCD-----------DNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYA 82
            :||..|.|:           ...|.|.|....|..:|..|....|.|::::|.|:.|.::..|..
Frog    28 DCPHSCSCEIRPWFTPKSIYIEALTVDCNALDLYSVPDKLPAKTQILLLQANNIEEIKNTDHFPV 92

  Fly    83 ELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQ 147
            .||.||||.|:|..|....|....::..|:|..||                        ::||.:
Frog    93 NLTGLDLSQNNLSLIANINFTNMHQILSVYLEENK------------------------LTELME 133

  Fly   148 GTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGM 212
            |:|:.|..::||.:..|.|..:.||||.|:|.|..|:|:.|.|..: :.:.|:|:|:|..|.:|.
Frog   134 GSFSGLENLQELYINHNLISVISPKAFAGVSNLLRLHLNSNRLQMI-NSMWFEAIPNLEILMIGE 197

  Fly   213 NTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRL 277
            |.:.:|:...|:.|..|..|.|.|.:|..|..::||||.:|..:...||:...:|||.|.|:|.|
Frog   198 NPIVNIEDMNFKPLINLRSLVLAGVNLTEIPDNAFLGLDKLESISFYDNKFIHVPSVALQKVVNL 262

  Fly   278 EQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQE 342
            :.|.|.:|....|..|.|..:..||.|.:|....|..:.:.|..:...|..:..::|..|..:..
Frog   263 KFLDLNKNPVRRIQRGDFSNMLHLKELGINNMPELVSIDSLAIENLPELRKIEATNNPKLAYIHP 327

  Fly   343 GALSGLSQLKHVVLKANALT----SLAEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNAS 403
            .|...|.:|:.::|.:|:|:    |..|.|   .:|:.:.:..||:.|||.:.|::....:....
Frog   328 NAFYRLPKLETLMLNSNSLSAIYRSTIEAL---PNLKEISIHSNPMRCDCVIRWINMNKTSIRFM 389

  Fly   404 QDDVSELLCEFPERLRGESLR--HLNPAMMGC--------------------------THADPRK 440
            :.|  .|.|..|...:|.::|  |....|..|                          ..|:|..
Frog   390 EPD--SLFCFDPPEFQGLNIRQVHFREMMEICLPLIAPQSFPLDLDLNTGSSVSLHCRATAEPEP 452

  Fly   441 QAL----IGALLVGSAA------------TITALALV---LYRCRHK---------IRETIKGGL 477
            :..    .|..||.:.|            ||..::|.   ||.|..|         |..|:.|..
Frog   453 EIYWITPSGYKLVPNIASGIFYVHPEGTLTIKNVSLAEAGLYTCVAKNLVGADLKTILITVDGSF 517

  Fly   478 WG--NSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHH----PGATHHYGMCP 536
            .|  |.:|....:|.|.......:.|:.:....|:...:.....||...|    |.....|.:..
Frog   518 TGEVNGSLKIIIKEVQSNSVMVSWKSKSKILKSSVQWTAYVKTEYTQIAHSVRMPSDIKQYNLTR 582

  Fly   537 M-PVNDLG-AIDPQQKFQQLV-----VPTA---TMISEKKLNNNKALV 574
            : |:.:.. .||....:|.:.     |.|.   ||:.|::..|:..::
Frog   583 LNPLTEYEICIDAPNIYQHIEKQCINVTTKGMDTMMKEREFINSATVI 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	5/17 (29%)
		LRR_8	83..142	CDD:290566	14/58 (24%)
		leucine-rich repeat	84..107	CDD:275380	10/22 (45%)
		leucine-rich repeat	108..131	CDD:275380	4/22 (18%)
		LRR_RI	129..421	CDD:238064	85/295 (29%)
		LRR_8	132..190	CDD:290566	19/57 (33%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		LRR_8	252..308	CDD:290566	19/55 (35%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..322	CDD:275380	6/20 (30%)
		LRR_8	325..384	CDD:290566	14/62 (23%)
		leucine-rich repeat	326..350	CDD:275380	5/23 (22%)
		leucine-rich repeat	351..373	CDD:275380	7/25 (28%)
lrrn3	NP_001072526.1	leucine-rich repeat	52..70	CDD:275380	5/17 (29%)
		leucine-rich repeat	71..93	CDD:275380	6/21 (29%)
		leucine-rich repeat	94..117	CDD:275380	10/22 (45%)
		leucine-rich repeat	118..141	CDD:275380	9/46 (20%)
		LRR_8	120..176	CDD:290566	23/79 (29%)
		leucine-rich repeat	142..165	CDD:275380	9/22 (41%)
		LRR_8	164..221	CDD:290566	19/57 (33%)
		leucine-rich repeat	166..189	CDD:275380	7/23 (30%)
		leucine-rich repeat	190..213	CDD:275380	7/22 (32%)
		LRR_8	213..272	CDD:290566	23/58 (40%)
		leucine-rich repeat	214..237	CDD:275380	10/22 (45%)
		leucine-rich repeat	238..261	CDD:275380	8/22 (36%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		leucine-rich repeat	286..310	CDD:275380	6/23 (26%)
		LRR_8	309..370	CDD:290566	14/63 (22%)
		leucine-rich repeat	311..333	CDD:275380	4/21 (19%)
		leucine-rich repeat	336..359	CDD:275378	7/25 (28%)
		leucine-rich repeat	360..372	CDD:275378	3/11 (27%)
		TPKR_C2	368..419	CDD:301599	14/52 (27%)
		I-set	429..513	CDD:254352	14/83 (17%)
		IGc2	437..503	CDD:197706	13/65 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11458
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4049
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14097
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060