DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Lrrc17

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_083253.1	Gene:	Lrrc17 / 74511	MGIID:	1921761	Length:	443	Species:	Mus musculus

Alignment Length:	430	Identity:	104/430 - (24%)
Similarity:	159/430 - (36%)	Gaps:	128/430 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PGCQCDDNTLV----VQCGEGQL-DVLPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTFLDLSS 91
            ||..||..|.:    :.|.|.:| .|||                        .:..:|..:.|:.
Mouse    52 PGLPCDVYTYLHEKYLDCQERKLVYVLP------------------------DWPQDLLHMLLAR 92

  Fly    92 NHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTF--TPLL 154
            |.:..:....||..|:|:.:.|..|:|.:|.::.|.||:.:|.|.|:.|||..|.:..|  ||||
Mouse    93 NKIRVLKNNMFAKFKRLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEAFIYTPLL 157

  Fly   155 K------------------IEELNLGENR-IG-YLDPKAFDGLSQLRILYLDDNALTTV------ 193
            .                  |..|.:..|| :| |....:...|...::|.|....|...
Mouse   158 SYLRLYDNPWHCTCELETLISMLQIPRNRNLGNYAKCGSPPALRNKKLLQLKPQELCDEEEKEQL 222

  Fly   194 -PDPVIFQAMPSL----AELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQEL 253
             |.|.: ..:|::    |:..|..|.:..||.   .|.|   |.|||... .||..|       :
Mouse   223 DPKPQV-SGIPAVIRPEADSTLCHNYVFPIQT---LDCK---RKELKKVP-SNIPPD-------I 272

  Fly   254 RILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTG 318
            ..||||.|::.::.......:..|::|:|..|..|.|...||:||..|:.|::
Mouse   273 VKLDLSSNKIRQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLIHLEELDL------------ 325

  Fly   319 AFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENP 383
                          ||..|.....|.|..|..||.:.|:.|          ||:
Mouse   326 --------------SNNSLQNFDYGVLEDLYFLKLLWLRDN----------PWR----------- 355

  Fly   384 LSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESL 423
              ||..:.:|:..|  |:......:.|.|:.||..:|.|:
Mouse   356 --CDYSIHYLYYWL--KHHYNVHYNGLECKTPEEYKGWSV 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	0/17 (0%)
		LRR_8	83..142	CDD:290566	18/58 (31%)
		leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_RI	129..421	CDD:238064	78/324 (24%)
		LRR_8	132..190	CDD:290566	21/79 (27%)
		leucine-rich repeat	132..155	CDD:275380	11/24 (46%)
		leucine-rich repeat	156..179	CDD:275380	7/24 (29%)
		leucine-rich repeat	180..204	CDD:275380	5/30 (17%)
		LRR_8	203..263	CDD:290566	20/63 (32%)
		leucine-rich repeat	205..228	CDD:275380	6/26 (23%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	17/55 (31%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		LRR_8	325..384	CDD:290566	12/58 (21%)
		leucine-rich repeat	326..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	6/21 (29%)
Lrrc17	NP_083253.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..48
		leucine-rich repeat	65..83	CDD:275380	6/41 (15%)
		LRR 1	84..105		4/20 (20%)
		leucine-rich repeat	85..108	CDD:275380	5/22 (23%)
		LRR_8	86..143	CDD:290566	17/56 (30%)
		LRR_4	107..148	CDD:289563	16/40 (40%)
		LRR 2	108..129		6/20 (30%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR 3	132..153		8/20 (40%)
		leucine-rich repeat	133..156	CDD:275380	9/22 (41%)
		leucine-rich repeat	157..207	CDD:275380	8/49 (16%)
		TPKR_C2	165..>201	CDD:301599	6/35 (17%)
		leucine-rich repeat	208..245	CDD:275380	7/37 (19%)
		leucine-rich repeat	251..271	CDD:275380	10/26 (38%)
		LRR_RI	<270..352	CDD:238064	27/114 (24%)
		LRR 4	271..292		6/27 (22%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		LRR_8	274..330	CDD:290566	19/81 (23%)
		LRR 5	295..316		8/20 (40%)
		LRR_4	296..334	CDD:289563	15/63 (24%)
		leucine-rich repeat	296..319	CDD:275380	10/22 (45%)
		LRR 6	319..342		7/48 (15%)
		leucine-rich repeat	320..343	CDD:275380	8/48 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100