DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and Lrrtm1

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001349038.1	Gene:	Lrrtm1 / 74342	MGIID:	2389173	Length:	522	Species:	Mus musculus

Alignment Length:	595	Identity:	134/595 - (22%)
Similarity:	212/595 - (35%)	Gaps:	176/595 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IWCIL-ASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTID 75
            :.|:| |...:.|||. :.||..|:|:...|..:           |||               :.
Mouse    21 VLCLLGACFQMLPAAP-SGCPGQCRCEGRLLYCE-----------ALN---------------LT 58

  Fly    76 SSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGN 140
            .:....:.|..|.|..|.|..:....|....:|..::|:||.|..:....|..|..|..|.|..|
Mouse    59 EAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSN 123

  Fly   141 QISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSL 205
            ||:||...||.|:..:..::|..|::..|.|..|.||.:|..|::..||:..|| ..|||...||
Mouse   124 QITELANTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVP-VRIFQDCRSL 187

  Fly   206 AELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVG 270
            ..|.:|.|.|:|:..::|..|..||.|.|:...|..::...|..|..|..|.|..|::..:.| .
Mouse   188 KFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLIKVNFAHFPRLISLHSLCLRRNKVAIVVS-S 251

  Fly   271 LSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNK 335
            |..:..||::.|..|:.|.:....|..:..|:.|::               |:..|.|
Mouse   252 LDWVWNLEKMDLSGNEIEYMEPHVFETVPYLQTLQL---------------DSNRLTY------- 294

  Fly   336 MLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRV----MWLHNL 396
                                ::...|.|       ||.|.::.|:.|...|...|    .||.|.
Mouse   295 --------------------IEPRILNS-------WKSLTSITLAGNLWDCGRNVCALASWLSNF 332

  Fly   397 LVAKNASQDDVSELLCEFPERLRGESL-----------------------------RHLNP---- 428
            ....:|:      |.|..||..:||.:                             ..|.|
Mouse   333 QGRYDAN------LQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSVAVTNRSDLTPPESS 391

  Fly   429 --------------------AMMGCTHADPRKQALIGALLVGSAATITA---LALVLY---RC-- 465
                                |:.|..||:...|  |..::.|:.|.|.:   :.||||   :|
Mouse   392 ATTLVDGGEGHDGTFEPITVALPGGEHAENAVQ--IHKVVTGTMALIFSFLIVVLVLYVSWKCFP 454

  Fly   466 --RHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPGA 528
              ..::|:..        ...|::::.::|......||..:::.           .|...|..||
Mouse   455 ASLRQLRQCF--------VTQRRKQKQKQTMHQMAAMSAQEYYV-----------DYKPNHIEGA 500

  Fly   529 ---THHYGMC 535
               .:.||.|
Mouse   501 LVIINEYGSC 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	0/17 (0%)
		LRR_8	83..142	CDD:290566	17/58 (29%)
		leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_RI	129..421	CDD:238064	78/295 (26%)
		LRR_8	132..190	CDD:290566	21/57 (37%)
		leucine-rich repeat	132..155	CDD:275380	11/22 (50%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	9/23 (39%)
		LRR_8	203..263	CDD:290566	20/59 (34%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	14/55 (25%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		LRR_8	325..384	CDD:290566	9/58 (16%)
		leucine-rich repeat	326..350	CDD:275380	2/23 (9%)
		leucine-rich repeat	351..373	CDD:275380	3/21 (14%)
Lrrtm1	NP_001349038.1	LRR 1	64..87		6/22 (27%)
		LRR	<75..>315	CDD:227223	76/290 (26%)
		LRR 2	89..111		6/21 (29%)
		leucine-rich repeat	91..114	CDD:275380	7/22 (32%)
		LRR 3	112..135		11/22 (50%)
		leucine-rich repeat	115..138	CDD:275380	11/22 (50%)
		LRR 4	136..159		5/22 (23%)
		leucine-rich repeat	139..162	CDD:275380	7/22 (32%)
		LRR 5	161..183		8/22 (36%)
		leucine-rich repeat	163..186	CDD:275380	9/23 (39%)
		LRR 6	184..207		8/22 (36%)
		leucine-rich repeat	187..210	CDD:275380	8/22 (36%)
		LRR 7	209..231		6/21 (29%)
		leucine-rich repeat	211..234	CDD:275380	7/22 (32%)
		LRR 8	233..255		6/22 (27%)
		leucine-rich repeat	235..257	CDD:275380	6/22 (27%)
		LRR 9	256..278		6/21 (29%)
		leucine-rich repeat	258..281	CDD:275380	6/22 (27%)
		LRR 10	280..302		6/63 (10%)
		leucine-rich repeat	282..300	CDD:275380	5/59 (8%)
		leucine-rich repeat	306..318	CDD:275378	3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010