DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Lingo3

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001103079.1	Gene:	Lingo3 / 690755	RGDID:	1592209	Length:	589	Species:	Rattus norvegicus

Alignment Length:	449	Identity:	119/449 - (26%)
Similarity:	189/449 - (42%)	Gaps:	85/449 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CILASIGVE----PAAGLA-NCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKT 73
            |.|..:|:.    |.|.|| .||..|:|..:|..|.||..:|..:|..:.
  Rat     3 CWLHMLGLHLLLLPTAPLATGCPARCECSASTRTVACGRRRLTAVPEGIP--------------- 52

  Fly    74 IDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLR 138
                    ||...|:||.|.:..:.....|....|:|:.||||.|..:....|..|..:.||.||
  Rat    53 --------AETRMLELSRNRIRCLNPGDLASLPTLEELDLNHNVIAHVEPGAFANLPRLRVLRLR 109

  Fly   139 GNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMP 203
            |||:..:..|.||.|..:..|:|.||::..|...:|..|..|:.|.:.||.|..:.... |..:.
  Rat   110 GNQLKLIPPGVFTHLDSLTLLDLSENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRA-FAGLL 173

  Fly   204 SLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFL---GLQELRI---------- 255
            .||||.|....|.|:..::...|:||..|.|:..::..:...:|.   ||..|.|
  Rat   174 GLAELTLERCNLTSLSPESLGHLRGLGALRLRHLAIAALEDQNFQKLPGLLHLEIDNWPLLEEVA 238

  Fly   256 -----------LDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGA 309
                       |.::...:..:|:..|.:...|..|:|..|...::..|:|..|.:|:.|.:.||
  Rat   239 PGSLRGLNLTSLSITHTNITAVPAAALRQQAHLTCLNLSHNPISMVPRGSFRDLVRLRELHLAGA 303

  Fly   310 LRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLF-PWKD 373
            |                          |..::..|..||.|::.:.|..|.|::|.|..| ....
  Rat   304 L--------------------------LAVIEPQAFVGLRQIRLLNLSDNLLSTLEENTFHSVNT 342

  Fly   374 LQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSEL-LCEFPERLRGESLRHLNPAMM 431
            |:||.:..|||:||||::|    :|.:..:.:....| .|..|..:||::|.:|..:::
  Rat   343 LETLRVDGNPLACDCRLLW----IVQRRKTLNFDGRLPACATPAEVRGDALHNLPDSVL 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	0/17 (0%)
		LRR_8	83..142	CDD:290566	21/58 (36%)
		leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_RI	129..421	CDD:238064	84/317 (26%)
		LRR_8	132..190	CDD:290566	22/57 (39%)
		leucine-rich repeat	132..155	CDD:275380	11/22 (50%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	6/23 (26%)
		LRR_8	203..263	CDD:290566	18/83 (22%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	6/25 (24%)
		LRR_8	252..308	CDD:290566	14/76 (18%)
		leucine-rich repeat	253..276	CDD:275380	5/43 (12%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..322	CDD:275380	5/20 (25%)
		LRR_8	325..384	CDD:290566	15/59 (25%)
		leucine-rich repeat	326..350	CDD:275380	4/23 (17%)
		leucine-rich repeat	351..373	CDD:275380	6/22 (27%)
Lingo3	NP_001103079.1	LRRNT	23..55	CDD:214470	11/54 (20%)
		leucine-rich repeat	34..53	CDD:275380	6/41 (15%)
		LRR	<55..353	CDD:227223	85/324 (26%)
		leucine-rich repeat	55..78	CDD:275380	5/22 (23%)
		leucine-rich repeat	79..102	CDD:275380	9/22 (41%)
		leucine-rich repeat	103..150	CDD:275380	18/46 (39%)
		leucine-rich repeat	151..174	CDD:275380	6/23 (26%)
		leucine-rich repeat	175..198	CDD:275380	8/22 (36%)
		leucine-rich repeat	199..222	CDD:275380	4/22 (18%)
		leucine-rich repeat	223..246	CDD:275380	3/22 (14%)
		LRR_8	246..302	CDD:404697	12/55 (22%)
		leucine-rich repeat	247..270	CDD:275380	3/22 (14%)
		leucine-rich repeat	271..292	CDD:275380	6/20 (30%)
		leucine-rich repeat	295..316	CDD:275380	7/46 (15%)
		leucine-rich repeat	319..342	CDD:275380	6/22 (27%)
		PCC	331..>405	CDD:188093	22/71 (31%)
		Ig	407..489	CDD:416386
		Ig strand A'	413..417	CDD:409353
		Ig strand B	423..432	CDD:409353
		Ig strand C	437..442	CDD:409353
		Ig strand C'	445..447	CDD:409353
		Ig strand D	456..459	CDD:409353
		Ig strand E	462..469	CDD:409353
		Ig strand F	475..483	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010