DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and Vasn

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001102852.1	Gene:	Vasn / 679921	RGDID:	1598149	Length:	673	Species:	Rattus norvegicus

Alignment Length:	423	Identity:	118/423 - (27%)
Similarity:	172/423 - (40%)	Gaps:	90/423 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTID-SSI 78
            :|..:|    :|:.:||.||||:....|. |...|...:|..:.|....|.|..|.|.|:| ...
  Rat    14 LLVLLG----SGVQSCPSGCQCNQPQTVF-CTARQGTTVPRDVPPDTVGLYIFENGITTLDVGCF 73

  Fly    79 QFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQIS 143
            ..:..|..||||.|.:.::|...|.....|..:.|..||:.:|||:||.||.
  Rat    74 AGFPGLQLLDLSQNQITSLPGGIFQPLVNLSNLDLTANKLHEISNETFRGLR------------- 125

  Fly   144 ELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAEL 208
                       ::|.|.||:|||.::.|.|||.|..|..|.|.||.|..:| |:   .:|.|..|
  Rat   126 -----------RLERLYLGKNRIRHIQPGAFDALDHLLELKLPDNELRVLP-PL---HLPRLLLL 175

  Fly   209 FLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSK 273
            .|..|::.:::| ...|...:..|.|.|..||.:....|..|:.|..||:|||:|..:|||
  Rat   176 DLSHNSIPALEA-GILDTANVEALRLAGLGLRQLDEGLFGRLRNLHDLDVSDNQLGHMPSV---- 235

  Fly   274 LVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLL 338
                                 ..||:.|.|                         |.|:.|..:.
  Rat   236 ---------------------IQGLRGLTR-------------------------LRLAGNTRIA 254

  Fly   339 EVQEGALSGLSQLKHV---VLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAK 400
            :::...|:||:.|:.:   .|...||.|....|||  .|:.|..:.||.:|.|.:.|....:...
  Rat   255 QIRPEDLAGLTALQELDVSNLSLQALPSDLSSLFP--RLRLLAAARNPFNCLCPLSWFGPWVRES 317

  Fly   401 NASQDDVSELLCEFPERLRGESLRHLNPAMMGC 433
            :.......|..|.||.:..|..|..|:.|..||
  Rat   318 HVVLASPEETRCHFPPKNAGRLLLELDYADFGC 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	6/18 (33%)
		LRR_8	83..142	CDD:290566	19/58 (33%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	11/22 (50%)
		LRR_RI	129..421	CDD:238064	74/294 (25%)
		LRR_8	132..190	CDD:290566	17/57 (30%)
		leucine-rich repeat	132..155	CDD:275380	0/22 (0%)
		leucine-rich repeat	156..179	CDD:275380	12/22 (55%)
		leucine-rich repeat	180..204	CDD:275380	8/23 (35%)
		LRR_8	203..263	CDD:290566	20/59 (34%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	14/55 (25%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	2/22 (9%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		LRR_8	325..384	CDD:290566	17/61 (28%)
		leucine-rich repeat	326..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	8/24 (33%)
Vasn	NP_001102852.1	LRRNT	25..55	CDD:214470	11/30 (37%)
		leucine-rich repeat	35..57	CDD:275380	5/22 (23%)
		PPP1R42	58..257	CDD:411060	76/277 (27%)
		leucine-rich repeat	58..78	CDD:275380	6/19 (32%)
		leucine-rich repeat	79..102	CDD:275380	8/22 (36%)
		leucine-rich repeat	103..126	CDD:275380	11/46 (24%)
		leucine-rich repeat	127..150	CDD:275380	12/22 (55%)
		leucine-rich repeat	151..194	CDD:275380	15/47 (32%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		leucine-rich repeat	219..241	CDD:275380	12/46 (26%)
		leucine-rich repeat	242..266	CDD:275380	8/48 (17%)
		leucine-rich repeat	267..290	CDD:275380	8/24 (33%)
		PCC	271..>350	CDD:188093	22/80 (28%)
		EGF	410..441	CDD:394967
		fn3	469..546	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010