DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and Tril

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_080093.1	Gene:	Tril / 66873	MGIID:	1914123	Length:	809	Species:	Mus musculus

Alignment Length:	475	Identity:	125/475 - (26%)
Similarity:	195/475 - (41%)	Gaps:	94/475 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IAFVGIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEG------------QLDVLPIALNP 59
            :..|..|.::......|....:.||..|.|.....::....|            ..|||..:|..
Mouse     4 VGAVRFWLVVCGCLAFPPRAESVCPERCDCQHPQHLLCTNRGLRAVPKTSSLPSPQDVLTYSLGG 68

  Fly    60 S---------------IQRLVIKSNKIKTI-DSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKL 108
            :               ::||.::.|:|::: ..:.:..:.|..|.|.:|.|..:...|.|..:||
Mouse    69 NFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALVPGTLAPLRKL 133

  Fly   109 QEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKA 173
            :.::.|.|:||::|..:|.||.::..|.|.||.:..|....|.||..:..|:|..|||.:|...|
Mouse   134 RILYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLESNRIRFLGKNA 198

  Fly   174 FDGLSQLRILYLDDNAL-TTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGA 237
            |..|.:||.|.|..|.| .::.....|..:.||:.|.|..|:||.:....||.|..|..|.|.|.
Mouse   199 FSQLGKLRFLNLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGN 263

  Fly   238 SLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLK 302
            .|.:::.::|.||:.||.|.|..|||:::|...|..|..||.|.|..|:...:....|
Mouse   264 QLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALHPATF------- 321

  Fly   303 RLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEG 367
                                 |:                :|.|..||      |:.|||::|:..
Mouse   322 ---------------------GH----------------QGRLRELS------LRDNALSALSGD 343

  Fly   368 LFPWKD-LQTLDLSENPLSCDCRV----MWLHNLLVAKNASQDDVSELL--CEFPERLRGESLRH 425
            :|.... |..|||..|..:||||:    .|:.|.     .||..:..:.  |..|..|||:.|.:
Mouse   344 IFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNW-----HSQGRLLTVFVQCRHPPALRGKYLDY 403

  Fly   426 LNPAMM---GCTHADPRKQA 442
            |:..::   .|....|...|
Mouse   404 LDDQLLQNGSCVDPSPSPTA 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	4/18 (22%)
		LRR_8	83..142	CDD:290566	21/58 (36%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_RI	129..421	CDD:238064	87/299 (29%)
		LRR_8	132..190	CDD:290566	22/57 (39%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..204	CDD:275380	7/24 (29%)
		LRR_8	203..263	CDD:290566	23/59 (39%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..308	CDD:290566	16/55 (29%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	0/20 (0%)
		LRR_8	325..384	CDD:290566	15/59 (25%)
		leucine-rich repeat	326..350	CDD:275380	3/23 (13%)
		leucine-rich repeat	351..373	CDD:275380	6/21 (29%)
Tril	NP_080093.1	LRR_RI	<11..194	CDD:238064	44/182 (24%)
		leucine-rich repeat	37..57	CDD:275378	1/19 (5%)
		LRR 1	61..81		3/19 (16%)
		LRR_8	84..143	CDD:290566	15/58 (26%)
		LRR 2	84..105		4/20 (20%)
		leucine-rich repeat	85..108	CDD:275380	4/22 (18%)
		LRR 3	108..129		6/20 (30%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		LRR 4	132..153		8/20 (40%)
		leucine-rich repeat	133..156	CDD:275380	9/22 (41%)
		LRR_8	156..215	CDD:290566	22/58 (38%)
		LRR 5	156..177		6/20 (30%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		LRR 6	180..201		8/20 (40%)
		leucine-rich repeat	181..204	CDD:275380	9/22 (41%)
		LRR 7	204..223		6/18 (33%)
		leucine-rich repeat	205..230	CDD:275380	7/24 (29%)
		LRR_RI	229..>364	CDD:238064	50/184 (27%)
		LRR_8	229..289	CDD:290566	23/59 (39%)
		LRR 8	230..251		8/20 (40%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR 9	254..275		6/20 (30%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		LRR 10	278..298		8/19 (42%)
		leucine-rich repeat	279..302	CDD:275380	10/22 (45%)
		LRR_8	302..359	CDD:290566	21/106 (20%)
		LRR 11	302..323		6/48 (13%)
		leucine-rich repeat	303..323	CDD:275380	6/47 (13%)
		LRR 12	326..347		9/26 (35%)
		leucine-rich repeat	327..350	CDD:275380	9/28 (32%)
		TPKR_C2	359..406	CDD:301599	16/51 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..462		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..563
		FN3	587..659	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970