DRSC/TRiP Functional Genomics Resources

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Protein Alignment trn and Hmcn2

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:XP_006498564.1 Gene:Hmcn2 / 665700 MGIID:2677838 Length:5092 Species:Mus musculus


Alignment Length:917 Identity:169/917 - (18%)
Similarity:293/917 - (31%) Gaps:344/917 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 AGLANC----PPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYA--- 82
            ||..:|    ..|.|..|..||||        :|..::|:....|....    :.:|:...|   
Mouse   947 AGRYSCVATNVAGSQHRDVELVVQ--------VPPRIHPTSTHHVTNEG----VPASLPCIASGV 999

  Fly    83 ---ELTF------------LDLSSNHLMTI----PQRTFAYQKKLQEVHLNHNKIGQISNKTFIG 128
               ::|:            ..:|.|..:.|    ||...||      |....|.:|..|.:.::.
Mouse  1000 PTPKITWTKETNALTTSGHYSVSRNGTLVIVQPSPQDAGAY------VCTATNSVGFSSQEMWLS 1058

  Fly   129 LSAVTVLNLRGNQISEL-----------------HQGTFTPL----------------------- 153
            ::...::.:.|:|..::                 .||:.|||                       
Mouse  1059 VNTKPMIKMNGSQAVDVPLRVTVKAGEEVTLDCEAQGSPTPLLTWTKDANPLLPVTNRYELLPSG 1123

  Fly   154 -LKIEELNLGEN--------------------RIGYLDPKAFDGLSQLRIL---YLDDNALTT-V 193
             |::.:..:|:|                    |: .:.|:...|...|::|   .||.|.:.. .
Mouse  1124 SLRLAQAQVGDNGLYGCTASNPAGATSRRYVLRV-QVPPQVQPGPRVLKVLAGEALDLNCVAEGN 1187

  Fly   194 PDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLK----GLTRLELKGASLRNISHDSFLGLQELR 254
            |.|.:......:|  .:|.....|:.   |..:|    ||.|.|...::    ..|::  ..||.
Mouse  1188 PQPQLNWFKDGMA--LMGEGAQGSVH---FAAVKTSDAGLYRCEASNSA----GTDTW--KLELL 1241

  Fly   255 IL-------DLSDNRLDRI---------PSVGLSKLVRL--------EQLSLGQNDFEVISEGAF 295
            :|       |.:.:.|:|:         |:.|..| .|:        |.|: |:.|..|:.|   
Mouse  1242 VLEPPHWGTDETKSLLERVAGENASLPCPAQGTPK-PRITWRRGPSSEPLN-GRPDVAVLDE--- 1301

  Fly   296 MGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSN---------KMLLEV-----QEGALS 346
                        |:|.|..|   :.:|:|  ||...::|         |:::.|     :||.::
Mouse  1302 ------------GSLFLSSV---SLADSG--EYECQATNEVGSASRRAKLVVYVPPSIREEGHIT 1349

  Fly   347 GLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDC--------RVMWL---------- 393
            .:|                            .|:..||:.:|        .|.||          
Mouse  1350 NVS----------------------------GLAGQPLTLECDINGFPAPEVAWLKDGQLIPEAS 1386

  Fly   394 -HNLLVAKNA-----SQDDVSELLCEFPERLRGESLRHLN------PAMMGCTHADPRKQALIGA 446
             |.||....:     .|:..|.|.....|...|.:.|..|      |:::|...|    |.::| 
Mouse  1387 GHRLLDGSRSLHFPRIQESHSGLYSCQAENQAGSAQRDFNLAVFIPPSLLGAGAA----QEVLG- 1446

  Fly   447 LLVGSAATITALAL----------------------VLYRCRHKIRETIKGGLWGN--------S 481
             |.|:..|:.....                      :|.:...::...|...|...        |
Mouse  1447 -LAGADVTLECQTSGVPTPQVEWTKDGQPILPGDPHILLQEDGQVLRIISSHLGDEGQYQCVAFS 1510

  Fly   482 ALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAID 546
            ..|::.:::|        :|.|...|.:.....|:|.:||.|...|:           |:.|.: 
Mouse  1511 PAGQQAKDFQ--------LSIHYGDPEAQRGERTYPRSYTPPTIWGS-----------NETGEV- 1555

  Fly   547 PQQKFQQLVVPTATMISEKKLNNNKALV--SQGAIDDSASFVLHMKSATMGRDVHQQNPQLNHYT 609
                 ..|...||.::.|.:...:.|:.  ..|.:...:|.|::.|.....:.|..|......||
Mouse  1556 -----TVLEGHTAQLLCEARGMPSPAITWYKDGTLLAPSSEVVYSKGGRQLQLVKAQPSDAGLYT 1615

  Fly   610 ----KPQFLSATATVGDSCYSYADVPMVHGAPLGGPNQPQ--------LRLTQEHFKQRELYDQE 662
                .|..::..:|   |...|.. |.:.||. |||...|        |...........:..|.
Mouse  1616 CQASNPAGITKKST---SLEVYVP-PTIEGAD-GGPYLVQAVAGRPVALECVARGHPPPTISWQH 1675

  Fly   663 MGSEILDHNYIYSNTHYSMPLEQLGRSK-------TPTPP-----------PMPPALPLRNGL-- 707
            .|..::|.|..:.....::.||..|.:.       ..:|.           .:||.|.:..|:  
Mouse  1676 EGLPVVDSNGTWLEAGGALQLENPGEASGGLYSCVASSPAGEAVLQYSVEMQVPPQLLVAEGMGQ 1740

  Fly   708 -CATTGR 713
             .||.|:
Mouse  1741 VTATVGQ 1747

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 2/17 (12%)
LRR_8 83..142 CDD:290566 13/74 (18%)
leucine-rich repeat 84..107 CDD:275380 8/38 (21%)
leucine-rich repeat 108..131 CDD:275380 4/22 (18%)
LRR_RI 129..421 CDD:238064 74/422 (18%)
LRR_8 132..190 CDD:290566 18/121 (15%)
leucine-rich repeat 132..155 CDD:275380 7/63 (11%)
leucine-rich repeat 156..179 CDD:275380 5/42 (12%)
leucine-rich repeat 180..204 CDD:275380 7/27 (26%)
LRR_8 203..263 CDD:290566 14/70 (20%)
leucine-rich repeat 205..228 CDD:275380 5/26 (19%)
leucine-rich repeat 229..252 CDD:275380 4/22 (18%)
LRR_8 252..308 CDD:290566 16/79 (20%)
leucine-rich repeat 253..276 CDD:275380 8/38 (21%)
leucine-rich repeat 277..300 CDD:275380 6/30 (20%)
leucine-rich repeat 301..322 CDD:275380 4/20 (20%)
LRR_8 325..384 CDD:290566 9/72 (13%)
leucine-rich repeat 326..350 CDD:275380 7/37 (19%)
leucine-rich repeat 351..373 CDD:275380 0/21 (0%)
Hmcn2XP_006498564.1 vWFA 38..196 CDD:238119
Ig 445..511 CDD:319273
IG 525..605 CDD:214652
I-set 609..693 CDD:369462
IG 707..783 CDD:214652
IG_like 793..876 CDD:214653
I-set 889..969 CDD:369462 7/21 (33%)
Ig 992..1058 CDD:386229 13/71 (18%)
IG 1076..1157 CDD:214652 8/80 (10%)
Ig 1161..1242 CDD:386229 21/91 (23%)
Ig 1262..1336 CDD:386229 20/95 (21%)
I-set 1345..1429 CDD:369462 20/111 (18%)
I-set 1449..1523 CDD:369462 8/81 (10%)
IG 1553..1633 CDD:214652 17/88 (19%)
IGc2 1654..1716 CDD:197706 9/61 (15%)
Ig 1741..1819 CDD:386229 3/7 (43%)
Ig 1839..1903 CDD:386229
I-set 1907..1986 CDD:369462
Ig_3 1998..2073 CDD:372822
Ig 2092..2179 CDD:386229
Ig 2183..2273 CDD:386229
Ig 2291..2367 CDD:386229
IGc2 2389..2451 CDD:197706
I-set 2476..2554 CDD:369462
I-set 2558..2650 CDD:369462
I-set 2668..2740 CDD:369462
Ig 2782..2859 CDD:386229
I-set 2876..2954 CDD:369462
I-set 2966..3046 CDD:369462
I-set 3050..3141 CDD:369462
Ig 3145..3233 CDD:386229
Ig 3256..3320 CDD:319273
Ig 3347..3422 CDD:386229
IG_like 3436..3511 CDD:214653
IGc2 3530..3592 CDD:197706
Ig 3614..3695 CDD:386229
I-set 3699..3786 CDD:369462
Ig 3789..3874 CDD:386229
Ig 3900..3967 CDD:319273
I-set 3974..4060 CDD:369462
Ig 4064..4151 CDD:386229
I-set 4155..4240 CDD:369462
IGc2 4259..4321 CDD:197706
I-set 4335..4421 CDD:369462
G2F 4423..4605 CDD:369383
FXa_inhibition 4664..4699 CDD:373209
EGF_CA 4701..4744 CDD:311536
EGF_CA 4746..4783 CDD:214542
EGF_CA 4789..4829 CDD:214542
EGF_CA 4896..4935 CDD:214542
EGF_CA 4936..4974 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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