DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and LRRN1

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001311117.1	Gene:	LRRN1 / 57633	HGNCID:	20980	Length:	716	Species:	Homo sapiens

Alignment Length:	420	Identity:	115/420 - (27%)
Similarity:	186/420 - (44%)	Gaps:	57/420 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ANCPPGCQCD-----------DNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKI-KTIDSSIQF 80
            :.||..|.|:           .....|.|.:.:|..:|..|:...|.|:::||.| ||:|...|.
Human    30 SECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQL 94

  Fly    81 YAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISEL 145
            : .||.||.|.|:...|           :||.|             ..|:.:|.|:|..|||:|:
Human    95 F-NLTELDFSQNNFTNI-----------KEVGL-------------ANLTQLTTLHLEENQITEM 134

  Fly   146 HQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFL 210
            .......|..::||.:..|:|..:...||.||..|..|:|:.|.|..: |...|.:.|:|..|.:
Human   135 TDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVI-DSRWFDSTPNLEILMI 198

  Fly   211 GMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLV 275
            |.|.:..|....|:.|..|..|.|.|..|.:|..::.:||..|..|...||:|.::|.:.|.|:.
Human   199 GENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVP 263

  Fly   276 RLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEV 340
            .|:.|.|.:|....|.||.|..:.:||.|.:|....|..|...|..:...|..|..::|..|..:
Human   264 NLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYI 328

  Fly   341 QEGALSGLSQLKHVVLKANALTSL----AEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAKN 401
            ...|...:..|:.::|..|||.::    .|.|   .:|:.:.:..|||.|||.:.|:       |
Human   329 HRLAFRSVPALESLMLNNNALNAIYQKTVESL---PNLREISIHSNPLRCDCVIHWI-------N 383

  Fly   402 ASQDDVS-----ELLCEFPERLRGESLRHL 426
            :::.::.     .:.|..|...:|..::.:
Human   384 SNKTNIRFMEPLSMFCAMPPEYKGHQVKEV 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	8/18 (44%)
		LRR_8	83..142	CDD:290566	15/58 (26%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..131	CDD:275380	4/22 (18%)
		LRR_RI	129..421	CDD:238064	86/300 (29%)
		LRR_8	132..190	CDD:290566	20/57 (35%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	20/59 (34%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..308	CDD:290566	19/55 (35%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	7/20 (35%)
		LRR_8	325..384	CDD:290566	14/62 (23%)
		leucine-rich repeat	326..350	CDD:275380	5/23 (22%)
		leucine-rich repeat	351..373	CDD:275380	7/25 (28%)
LRRN1	NP_001311117.1	LRR_RI	13..273	CDD:238064	79/268 (29%)
		leucine-rich repeat	54..73	CDD:275380	5/18 (28%)
		LRR 1	73..95		9/21 (43%)
		leucine-rich repeat	74..96	CDD:275380	9/22 (41%)
		LRR 2	96..117		10/44 (23%)
		leucine-rich repeat	97..120	CDD:275380	11/46 (24%)
		LRR_8	119..179	CDD:290566	20/59 (34%)
		LRR 3	120..141		7/20 (35%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR 4	144..165		6/20 (30%)
		leucine-rich repeat	145..168	CDD:275380	8/22 (36%)
		LRR 5	168..189		7/21 (33%)
		leucine-rich repeat	169..192	CDD:275380	7/23 (30%)
		LRR 6	192..213		6/20 (30%)
		leucine-rich repeat	193..216	CDD:275380	7/22 (32%)
		LRR_8	216..275	CDD:290566	20/58 (34%)
		LRR 7	216..237		6/20 (30%)
		leucine-rich repeat	217..240	CDD:275380	8/22 (36%)
		LRR_RI	240..>376	CDD:238064	39/138 (28%)
		LRR 8	240..261		7/20 (35%)
		leucine-rich repeat	241..264	CDD:275380	8/22 (36%)
		LRR_8	263..323	CDD:290566	17/59 (29%)
		LRR 9	264..285		8/20 (40%)
		leucine-rich repeat	265..288	CDD:275380	8/22 (36%)
		leucine-rich repeat	289..313	CDD:275380	7/23 (30%)
		LRR_8	312..373	CDD:290566	14/63 (22%)
		LRR 10	313..335		5/21 (24%)
		leucine-rich repeat	314..335	CDD:275380	5/20 (25%)
		LRR 11	338..359		5/20 (25%)
		leucine-rich repeat	339..362	CDD:275378	7/25 (28%)
		leucine-rich repeat	363..375	CDD:275378	4/11 (36%)
		LRRCT	371..419	CDD:214507	11/50 (22%)
		I-set	429..516	CDD:254352
		Ig	431..516	CDD:299845
		fn3	531..600	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4346
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8524
orthoMCL	1	0.900	-	-		OOG6_103993
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.960