DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and igfals

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_003198203.1	Gene:	igfals / 570758	ZFINID:	ZDB-GENE-061009-25	Length:	614	Species:	Danio rerio

Alignment Length:	456	Identity:	121/456 - (26%)
Similarity:	192/456 - (42%)	Gaps:	103/456 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CPPGCQC--DDNTLV--VQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDS-SIQFYAELTFLDL 89
            |..||.|  ||.:|.  |.|.......:|..:..|.:.|.:..|....:.: :.:....|.||:|
Zfish    49 CAKGCTCLQDDYSLELNVYCSTRNFTQVPSDIPLSTRSLWLDGNLFSNLPAGAFEKLTNLEFLNL 113

  Fly    90 SSNHLMTIPQRTFAYQKKLQEVH------------------------LNHNKIGQISNKTFIGLS 130
            .|:.|:::....|.....|..:|                        ||:|::.:|.::.|.|:|
Zfish   114 QSSLLVSLDAHAFRGLNSLAHLHLERNNLRSLSGLVFQGTSNLATLSLNNNQMFRIDDRLFAGMS 178

  Fly   131 AVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPD 195
            .:.:|||..|.:|.|.:..|..|..:.||.|..||:.||.|:.|.||::|:.|.|..|.|..:..
Zfish   179 HMWLLNLGWNLLSVLPETGFQDLHGLRELILAGNRLAYLQPQLFQGLNELKELDLTGNYLKVIKA 243

  Fly   196 PVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSD 260
            .| |..:|.|.:|:||.|.:.::...||..:|.|..|:|....|..:..::|:|||.|.:|.||:
Zfish   244 NV-FLKLPKLQKLYLGQNQIVTVAPRAFVGMKSLRWLDLSRNRLTVLHDETFIGLQSLHVLRLSN 307

  Fly   261 NRL---------------------DRIPSVGL---SKLVRLEQLSLGQNDFEVISEGAFMGLKQL 301
            |.:                     ::|.::|:   ..|..||.|:|..|..:....|.||||..|
Zfish   308 NSINSLRPGTFRDLQYLEELCLYHNQIRALGVRVFEGLGHLEVLNLENNRLQEARMGTFMGLNHL 372

  Fly   302 KRLEVNG------------------ALRLKRV------------MTG-----------------A 319
            ..:::.|                  ::.|.|.            :||                 :
Zfish   373 AVMKLTGSCFHSLPDQVFKGLSKLHSIHLDRSCLTKVSSQSFSGLTGLRRLFLQHNNISLVERQS 437

  Fly   320 FSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSL-AEGLFPWKDLQTLDLSENP 383
            |.:...|:.|:|..|| |..:......||..|.:::|..|.|.:| ||.|.|.:.|..||||.|.
Zfish   438 FVELQRLQQLDLRFNK-LTTITSNTFYGLKNLDYLLLSGNLLHNLPAEALLPLQHLSWLDLSGNK 501

  Fly   384 L 384
            |
Zfish   502 L 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/18 (11%)
		LRR_8	83..142	CDD:290566	20/82 (24%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..131	CDD:275380	8/46 (17%)
		LRR_RI	129..421	CDD:238064	93/328 (28%)
		LRR_8	132..190	CDD:290566	23/57 (40%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	11/22 (50%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	22/59 (37%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	19/79 (24%)
		leucine-rich repeat	253..276	CDD:275380	8/46 (17%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		leucine-rich repeat	301..322	CDD:275380	7/67 (10%)
		LRR_8	325..384	CDD:290566	23/59 (39%)
		leucine-rich repeat	326..350	CDD:275380	8/23 (35%)
		leucine-rich repeat	351..373	CDD:275380	9/22 (41%)
igfals	XP_003198203.1	LRRNT	48..81	CDD:279764	10/31 (32%)
		leucine-rich repeat	65..83	CDD:275380	3/17 (18%)
		leucine-rich repeat	84..107	CDD:275380	2/22 (9%)
		LRR_8	85..142	CDD:290566	11/56 (20%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_8	131..214	CDD:290566	21/82 (26%)
		leucine-rich repeat	132..155	CDD:275380	2/22 (9%)
		leucine-rich repeat	156..203	CDD:275380	15/46 (33%)
		leucine-rich repeat	204..227	CDD:275380	11/22 (50%)
		LRR_RI	<219..456	CDD:238064	59/238 (25%)
		LRR_8	227..286	CDD:290566	19/59 (32%)
		leucine-rich repeat	228..251	CDD:275380	7/23 (30%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR_8	274..334	CDD:290566	14/59 (24%)
		leucine-rich repeat	276..299	CDD:275380	7/22 (32%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		leucine-rich repeat	324..347	CDD:275380	3/22 (14%)
		leucine-rich repeat	348..369	CDD:275380	8/20 (40%)
		LRR_8	371..430	CDD:290566	6/58 (10%)
		leucine-rich repeat	396..419	CDD:275380	2/22 (9%)
		LRR_8	418..478	CDD:290566	14/60 (23%)
		leucine-rich repeat	420..443	CDD:275380	1/22 (5%)
		leucine-rich repeat	444..467	CDD:275380	8/23 (35%)
		LRR_8	466..524	CDD:290566	16/37 (43%)
		leucine-rich repeat	468..486	CDD:275380	7/17 (41%)
		leucine-rich repeat	492..515	CDD:275380	7/11 (64%)
		leucine-rich repeat	516..540	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010