DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and lrrtm4l2

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_009302017.1	Gene:	lrrtm4l2 / 568695	ZFINID:	ZDB-GENE-080327-14	Length:	557	Species:	Danio rerio

Alignment Length:	697	Identity:	146/697 - (20%)
Similarity:	245/697 - (35%)	Gaps:	218/697 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IW-----CIL--ASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSN 69
            :|     |.|  ||:.:..:.|...||..|:|:..  :|.|..|....:|..::...|.|.::.|
Zfish     5 LWEGRLSCFLLHASVLLLLSKGERMCPVSCRCEGK--IVYCESGGFQDVPENISLGCQGLSLRYN 67

  Fly    70 KIKTIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTV 134
            .:                      |:.:|.: ||:..:|..::|:||.|..:....|.||..:..
Zfish    68 SL----------------------LLLLPYQ-FAHLNQLVWLYLDHNSISTVDRLAFQGLRRLKE 109

  Fly   135 LNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIF 199
            |.|..|:|::|..|||..:..:..|:|..|::..|.|..|.||.:|:.|:|..
Zfish   110 LILSSNKIAQLQNGTFETVPNLRNLDLSYNQMQDLVPGHFHGLRKLQNLHLRS------------ 162

  Fly   200 QAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLD 264
                         |.::||....|.:.:.|..|:|....||.|:..:||||..|..|.|..|:..
Zfish   163 -------------NNIRSIPVRTFMECRSLEFLDLGYNRLRTITRTTFLGLLRLTELHLEHNQFS 214

  Fly   265 RIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYL 329
            ||......:|:.|:.|.|..|....:.:|:......|::|:::|. .::.:....|....||..|
Zfish   215 RINFFLFPRLLNLQALYLQWNRIRTVVQGSPWTWHTLQKLDLSGN-EIQILDPAIFRCLPNLHTL 278

  Fly   330 NLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCR----V 390
            ||.|||         :|.:|               .|.:..|..:.|::|:.|...|...    |
Zfish   279 NLESNK---------ISNVS---------------LEVVSSWISISTINLAGNIWDCSSSICPLV 319

  Fly   391 MWLHNLLVAKNASQDDVSELLCEFPERLRGE----SLRHLNPAMMGCTHADPRKQALIGALLVGS 451
            .||.|....::||      ::|..|:.|:||    ::|: |.........:|..:..:
Zfish   320 SWLRNFRGTRDAS------IICSTPKSLQGERVMDAVRN-NSVCEEMFTVEPTTELTL------- 370

  Fly   452 AATITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTF 516
              .:|.....||..:.....|                                          |.
Zfish   371 --LLTTTTTTLYVTKPPTTTT------------------------------------------TT 391

  Fly   517 PNTYTAPHHPGATHHYGMCP---MPVNDLGAIDPQQKFQQLVVPTATMISEKKLNN---NKALVS 575
            |.| |.......||...:.|   :||.      |:::|..:...:.....|.:..:   :|.:..
Zfish   392 PRT-TTRQLSQVTHIQRLTPKVLLPVR------PEKEFLTVTPSSLPFTPEPEFEHMTFHKIIAG 449

  Fly   576 QGAIDDSASFVL---------------HMKSATMGR--------DVHQQNPQLNHYTKPQFLS-- 615
            ..|:..|.|.:|               .::..::.|        ..|..|.||..|    :||
Zfish   450 SVALFLSVSLILLVIYVSWRRYPNSMRQLQQHSIRRKRRKKTREPEHNINSQLQEY----YLSYN 510

  Fly   616 --------------ATATVG-----DSCYSY---------ADVPMVH 634
                          .|.|:.     ::.|||         .|||.:|
Zfish   511 HANAETMDSLVNGACTCTISGSRECENAYSYPRPLPGAWMGDVPTIH 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	3/17 (18%)
		LRR_8	83..142	CDD:290566	15/58 (26%)
		leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_RI	129..421	CDD:238064	75/295 (25%)
		LRR_8	132..190	CDD:290566	19/57 (33%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	3/23 (13%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		LRR_8	252..308	CDD:290566	14/55 (25%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..322	CDD:275380	4/20 (20%)
		LRR_8	325..384	CDD:290566	15/58 (26%)
		leucine-rich repeat	326..350	CDD:275380	8/23 (35%)
		leucine-rich repeat	351..373	CDD:275380	2/21 (10%)
lrrtm4l2	XP_009302017.1	LRR_8	<74..117	CDD:290566	14/43 (33%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		LRR_8	105..165	CDD:290566	20/84 (24%)
		LRR_RI	107..307	CDD:238064	63/249 (25%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_8	153..213	CDD:290566	21/84 (25%)
		leucine-rich repeat	155..178	CDD:275380	7/47 (15%)
		leucine-rich repeat	179..202	CDD:275380	10/22 (45%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		LRR_8	226..285	CDD:290566	17/68 (25%)
		leucine-rich repeat	227..250	CDD:275380	5/22 (23%)
		leucine-rich repeat	251..274	CDD:275380	4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100