DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and lingo3a

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001076323.1	Gene:	lingo3a / 567293	ZFINID:	ZDB-GENE-060503-54	Length:	605	Species:	Danio rerio

Alignment Length:	398	Identity:	112/398 - (28%)
Similarity:	180/398 - (45%)	Gaps:	34/398 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTID-SSIQFYAELTFLDLSSN 92
            :||..|.|..:...|.|...:|..:|..:....:.|.:..|.::.:: :.:.....|..||||.|
Zfish    26 SCPQRCDCIPHQRAVMCQNKRLGSIPGGIPADTRLLDLSCNSLRWVEYNDLSTLLRLEELDLSEN 90

  Fly    93 HLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIE 157
            .:..:....|:....|:.:.|..|::..:....|..|:.:|.|:|.||::..|...||..|..:.
Zfish    91 LISVLEPNAFSSLLNLRVLRLRANQLKLVPMGAFSRLTNLTTLDLSGNKLVILLDFTFQDLRNLR 155

  Fly   158 ELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADA 222
            .|.:|:|.:.|:..|||.||..||.|.::...||::....: ..:..|..|.|...::.|::...
Zfish   156 NLEVGDNDLVYISNKAFLGLVGLRELTIERCNLTSISGQSL-SYLRGLVTLRLRYLSIASLEEQN 219

  Fly   223 FQDLKGLTRLEL-KGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQND 286
            |:.|.||..||: ....|..||..||.|| .|..|.:::..:..:|:..|..|:.|..|:|..|.
Zfish   220 FRKLGGLRGLEIDHWPFLEYISPHSFQGL-NLSWLSITNTNISTVPTGALRNLIHLASLNLSYNP 283

  Fly   287 FEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQL 351
            ..|:...|...|.:||.|.:.|.                          .|:.||...|.||.|:
Zfish   284 ISVLESWALRDLVRLKELHLVGT--------------------------NLISVQPYGLGGLQQI 322

  Fly   352 KHVVLKANALTSLAEGLF-PWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFP 415
            :.:.|..|.|.:|.||.| ....|:||.:..||||||||::|   :|..:.....|....:|..|
Zfish   323 RLLNLSNNGLVTLEEGSFHSVNTLETLRVDGNPLSCDCRLLW---ILQRRKTLNFDGKSPVCTAP 384

  Fly   416 ERLRGESL 423
            ..:||:||
Zfish   385 VEVRGKSL 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/18 (11%)
		LRR_8	83..142	CDD:290566	17/58 (29%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..131	CDD:275380	5/22 (23%)
		LRR_RI	129..421	CDD:238064	88/293 (30%)
		LRR_8	132..190	CDD:290566	21/57 (37%)
		leucine-rich repeat	132..155	CDD:275380	9/22 (41%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..204	CDD:275380	5/23 (22%)
		LRR_8	203..263	CDD:290566	19/60 (32%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	10/23 (43%)
		LRR_8	252..308	CDD:290566	15/55 (27%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..322	CDD:275380	4/20 (20%)
		LRR_8	325..384	CDD:290566	18/59 (31%)
		leucine-rich repeat	326..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	7/22 (32%)
lingo3a	NP_001076323.1	LRRNT	27..60	CDD:214470	8/32 (25%)
		LRR	<49..357	CDD:227223	90/335 (27%)
		leucine-rich repeat	58..81	CDD:275380	2/22 (9%)
		leucine-rich repeat	82..105	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	9/22 (41%)
		leucine-rich repeat	154..177	CDD:275380	9/22 (41%)
		leucine-rich repeat	178..201	CDD:275380	5/23 (22%)
		leucine-rich repeat	202..225	CDD:275380	6/22 (27%)
		leucine-rich repeat	226..249	CDD:275380	10/23 (43%)
		leucine-rich repeat	250..273	CDD:275380	5/22 (23%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		leucine-rich repeat	298..321	CDD:275380	10/48 (21%)
		leucine-rich repeat	322..342	CDD:275380	7/19 (37%)
		PCC	326..>392	CDD:188093	25/68 (37%)
		Ig	424..492	CDD:325142
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010