DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and lingo1a

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_005174327.1	Gene:	lingo1a / 564943	ZFINID:	ZDB-GENE-080327-16	Length:	615	Species:	Danio rerio

Alignment Length:	641	Identity:	147/641 - (22%)
Similarity:	238/641 - (37%)	Gaps:	188/641 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VGIW--CILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIK 72
            |..|  .::..:|...:.....||..|:|:.....|.|...:|..:|..: ||..||
Zfish    13 VACWQPILILMLGTVLSGSATGCPSRCECNVQERSVLCHRKKLMSVPEGI-PSETRL-------- 68

  Fly    73 TIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNL 137
                          ||||.|.:.||....|:...:|:|:.||.|.|..|....|..|..:..|.|
Zfish    69 --------------LDLSKNRIKTINPDEFSAFPQLEELELNENTISAIEPGAFNNLYGLQTLGL 119

  Fly   138 RGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAM 202
            |.|::..:..|.||.|..:.:|::.||:|..|....|..|..||.|.:.||.|..:.... |..:
Zfish   120 RSNKLKLIQLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLRSLEVGDNDLVFISHRA-FHGL 183

  Fly   203 PSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILD---------- 257
            .||.:|.|....|.|:..:||..|..|..|.|:..::.:|...||..|..|::|:
Zfish   184 SSLEQLTLEKCNLTSVPTEAFTHLHSLVTLRLRNLNINSIRDYSFKRLYRLKVLEIANWPYLDTM 248

  Fly   258 --------------LSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNG 308
                          :::..|..||.:.|..||.|..|::..|..::|.......|.:|:.|.:.|
Zfish   249 TTNCLYGLNLTSLTITNANLTSIPYLALRHLVYLRFLNMSYNPIQMIEGNRLHDLLRLQELYLVG 313

  Fly   309 ALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLF-PWK 372
                           |.|..           ::..:..||:.||.:.:.:|.||:|.|.:| ...
Zfish   314 ---------------GRLSV-----------IEPYSFRGLNYLKVLNVSSNFLTTLEESVFHSVG 352

  Fly   373 DLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRH----LNPAMMGC 433
            :|:||.|.:|||:||||::|:.......|.::...:   |..||.::|:..:.    |.|....|
Zfish   353 NLETLALHDNPLACDCRLLWVFRRRWRLNFNRQQPT---CSSPEFVQGKEFKDFPDILQPNYFTC 414

  Fly   434 THADPRKQALIGALLVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDED 498
                 ||..:                                          ::|:.|:.|.||
Zfish   415 -----RKSRI------------------------------------------RDRKPQQKFVDE- 431

  Fly   499 YMSRHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGMC-----PMPVNDLGAIDPQQKF------- 551
                                        |.|.|: :|     |.||  :..:.||::|
Zfish   432 ----------------------------GTTVHF-VCQADGDPTPV--IMWLSPQKQFITMKTIG 465

  Fly   552 QQLVVPTATM-ISEKKLNNN---KALVSQGAIDDSASFVLHMKSATMGRDVHQQNP 603
            :..|.|..|: :...::.:|   ..:.|....:|:|...||         ||..:|
Zfish   466 RLTVFPDGTLEVRYAQIQDNGTYGCIASNAGGNDTALAHLH---------VHSYSP 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/17 (12%)
		LRR_8	83..142	CDD:290566	21/58 (36%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_RI	129..421	CDD:238064	83/316 (26%)
		LRR_8	132..190	CDD:290566	20/57 (35%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	18/83 (22%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	15/79 (19%)
		leucine-rich repeat	253..276	CDD:275380	7/46 (15%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..322	CDD:275380	3/20 (15%)
		LRR_8	325..384	CDD:290566	16/59 (27%)
		leucine-rich repeat	326..350	CDD:275380	3/23 (13%)
		leucine-rich repeat	351..373	CDD:275380	8/22 (36%)
lingo1a	XP_005174327.1	LRRNT	34..68	CDD:214470	10/34 (29%)
		LRR_RI	<55..231	CDD:238064	60/199 (30%)
		leucine-rich repeat	66..89	CDD:275380	10/44 (23%)
		LRR_8	88..148	CDD:290566	20/59 (34%)
		leucine-rich repeat	90..113	CDD:275380	9/22 (41%)
		leucine-rich repeat	114..137	CDD:275380	8/22 (36%)
		LRR_8	136..196	CDD:290566	18/60 (30%)
		leucine-rich repeat	138..185	CDD:275380	14/47 (30%)
		LRR_8	184..241	CDD:290566	18/56 (32%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..257	CDD:275380	9/46 (20%)
		leucine-rich repeat	234..256	CDD:275380	2/21 (10%)
		LRR_8	257..316	CDD:290566	15/73 (21%)
		leucine-rich repeat	258..281	CDD:275380	5/22 (23%)
		leucine-rich repeat	282..305	CDD:275380	5/22 (23%)
		LRR_8	305..364	CDD:290566	20/84 (24%)
		leucine-rich repeat	306..329	CDD:275380	7/48 (15%)
		leucine-rich repeat	330..350	CDD:275380	8/19 (42%)
		TPKR_C2	362..>398	CDD:301599	12/38 (32%)
		I-set	421..507	CDD:254352	24/126 (19%)
		Ig	432..507	CDD:299845	19/86 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010