DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and lingo2b

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001139054.1	Gene:	lingo2b / 564052	ZFINID:	ZDB-GENE-080723-57	Length:	607	Species:	Danio rerio

Alignment Length:	439	Identity:	118/439 - (26%)
Similarity:	188/439 - (42%)	Gaps:	86/439 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTID----SSIQFYAELTFLDLS 90
            ||..|:|...|..|.|...:|..:|..:....:.|.:..|:::.:.    ||:....|   ||||
Zfish    27 CPARCECSVPTRSVSCHRRRLAQVPEGIPIETRSLDLSKNRLRIVTPQNFSSLLLLEE---LDLS 88

  Fly    91 SNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLK 155
            :|.|.::...:|..|.:|:.:.|..|::..:......|||.:|:|::..|::..|....|....:
Zfish    89 NNLLSSVEPNSFRAQPRLRSLRLRSNQLTLLPRGALAGLSELTLLDVSQNRLVILLDYGFEEQRR 153

  Fly   156 IEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVI--FQAMPSL-------AEL--- 208
            :..|.|.:|.:.::.|:||.||:.||.|.|....|:|||...:  ...:.||       |||
Zfish   154 LRVLELSDNELVFIAPRAFSGLASLRSLTLQRCNLSTVPTHALAHLHGLTSLRLRDLGIAELQAH 218

  Fly   209 -FLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLS 272
             |.|:..|:.::.|.:..|:|.....|:|.:|..:|              ::...|..:|.|  :
Zfish   219 TFKGLPRLKHLEVDRWPLLEGFPTSALQGLNLSTLS--------------ITHTNLTSVPVV--T 267

  Fly   273 KLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKML 337
            .|:.|..|:|..:...|:..|...|:.:|:.|.|..|                          .|
Zfish   268 NLLYLTHLNLSYSRIRVLPAGWLRGMDRLEVLRVRQA--------------------------NL 306

  Fly   338 LEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKD-LQTLDLSENPLSCDCRVMWLHNLLVAKN 401
            |.|:..|..|.|.|:.:.|..|.|.:|...:||..: ||||.:.:|||.||||:.||
Zfish   307 LSVEPQAFQGASSLRILDLCYNRLATLERSVFPVTEALQTLLIGQNPLVCDCRLRWL-------- 363

  Fly   402 ASQDDVSELL-------CEFPERLRGESLRHLNPAMMG----CTHADPR 439
              .:....||       |..|..|.|:.||.|..|.:.    ||  .||
Zfish   364 --LERTPPLLYGDVQPECSAPAPLAGKPLRDLVEAQISRYVICT--KPR 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	4/21 (19%)
		LRR_8	83..142	CDD:290566	18/58 (31%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	5/22 (23%)
		LRR_RI	129..421	CDD:238064	83/312 (27%)
		LRR_8	132..190	CDD:290566	17/57 (30%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	8/25 (32%)
		LRR_8	203..263	CDD:290566	15/70 (21%)
		leucine-rich repeat	205..228	CDD:275380	9/33 (27%)
		leucine-rich repeat	229..252	CDD:275380	4/22 (18%)
		LRR_8	252..308	CDD:290566	13/55 (24%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	4/20 (20%)
		LRR_8	325..384	CDD:290566	18/59 (31%)
		leucine-rich repeat	326..350	CDD:275380	5/23 (22%)
		leucine-rich repeat	351..373	CDD:275380	7/21 (33%)
lingo2b	NP_001139054.1	LRRNT	26..58	CDD:214470	9/30 (30%)
		leucine-rich repeat	37..60	CDD:275380	5/22 (23%)
		LRR_8	59..116	CDD:290566	16/59 (27%)
		leucine-rich repeat	61..81	CDD:275380	4/19 (21%)
		LRR_RI	<103..214	CDD:238064	30/110 (27%)
		LRR_8	104..188	CDD:290566	23/83 (28%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..177	CDD:275380	8/22 (36%)
		leucine-rich repeat	178..201	CDD:275380	8/22 (36%)
		LRR_8	201..260	CDD:290566	15/72 (21%)
		leucine-rich repeat	202..225	CDD:275380	7/22 (32%)
		leucine-rich repeat	226..271	CDD:275380	12/60 (20%)
		LRR_8	272..330	CDD:290566	19/83 (23%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	9/48 (19%)
		leucine-rich repeat	320..338	CDD:275380	5/17 (29%)
		leucine-rich repeat	344..356	CDD:275378	7/11 (64%)
		LRRCT	352..394	CDD:214507	17/51 (33%)
		IG_like	419..497	CDD:214653
		Ig	422..497	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010