DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and zgc:153913

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001073448.1	Gene:	zgc:153913 / 559700	ZFINID:	ZDB-GENE-061103-397	Length:	496	Species:	Danio rerio

Alignment Length:	457	Identity:	121/457 - (26%)
Similarity:	204/457 - (44%)	Gaps:	69/457 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MMIAFVGIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSN 69
            :::..:.::|     ||       .||..|||...:.:| |.:.::..||:.::..::.|::.::
Zfish     8 VLLVLIHLYC-----GV-------CCPEPCQCFSGSKLV-CSDDRMKSLPVNISTQVRELIVVAS 59

  Fly    70 KIKTID----------SSIQF---------------YAELTFLDLSSNHL-MTIPQRTFAYQKKL 108
            .|..:|          |.:.|               ..||..|::|.|.. |::..:||:....|
Zfish    60 GIPDLDQQSFPETLRLSKLVFLNGMLKSVSGEAFERLVELRELEISGNICWMSLDIQTFSSLTNL 124

  Fly   109 QEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKA 173
            ..:.||:||:..:....|..|..:.:|.||||.:|.|....|..|.:::||:|..|:|..|..:.
Zfish   125 TRLLLNNNKLSGVDAGLFHSLHQLEMLQLRGNGLSFLSGRLFQRLHRLQELDLSFNQISSLSTEL 189

  Fly   174 FDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGAS 238
            |...|:||:|.|..|.:..:||. ||..:..|.||.|..|.::.:...:|.  ..|..|.||...
Zfish   190 FQNNSELRVLSLQANKIPNLPDG-IFTHLDHLQELNLRSNLIRVLTPGSFP--ASLKTLILKKNL 251

  Fly   239 LRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKR 303
            |..:::..|..|..:..||||.|.|..:|:.....|:.||.|.|.:|....::...|.||..:|.
Zfish   252 LEKLTNAVFHTLHYITYLDLSQNSLTEVPADLFQNLISLETLDLSENRISTLAGSVFKGLFSIKS 316

  Fly   304 LEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGL 368
            :                       ||..:|   |:.|....|.....|:.:.|..|:|.|:..|.
Zfish   317 V-----------------------YLQKNS---LISVDAHLLKDQHDLQLLDLSNNSLRSIPSGF 355

  Fly   369 FPWKDLQ-TLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMG 432
            |...|.| ..:|..||.||||.:.:.::.|...:....|:|.:.||.||.::|.:||.::...:.
Zfish   356 FEDLDFQCVFELRGNPWSCDCGIHYFYDWLKYNHKHVKDLSRVSCEAPELIQGHNLRSVDREQLV 420

  Fly   433 CT 434
            |:
Zfish   421 CS 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	4/27 (15%)
		LRR_8	83..142	CDD:290566	20/59 (34%)
		leucine-rich repeat	84..107	CDD:275380	7/23 (30%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_RI	129..421	CDD:238064	86/292 (29%)
		LRR_8	132..190	CDD:290566	22/57 (39%)
		leucine-rich repeat	132..155	CDD:275380	9/22 (41%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	9/23 (39%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	17/55 (31%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	1/20 (5%)
		LRR_8	325..384	CDD:290566	17/59 (29%)
		leucine-rich repeat	326..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	7/21 (33%)
zgc:153913	NP_001073448.1	leucine-rich repeat	75..98	CDD:275380	2/22 (9%)
		LRR_RI	141..>350	CDD:238064	68/237 (29%)
		LRR_8	147..206	CDD:290566	22/58 (38%)
		leucine-rich repeat	148..171	CDD:275380	9/22 (41%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		LRR_8	194..252	CDD:290566	20/60 (33%)
		leucine-rich repeat	196..219	CDD:275380	9/23 (39%)
		leucine-rich repeat	220..241	CDD:275380	6/22 (27%)
		leucine-rich repeat	242..265	CDD:275380	7/22 (32%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		LRR_8	267..324	CDD:290566	20/82 (24%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..337	CDD:275380	7/48 (15%)
		leucine-rich repeat	338..359	CDD:275380	7/20 (35%)
		TPKR_C2	370..>404	CDD:301599	11/33 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D187891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6410
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950