DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and flrt3

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001243575.1	Gene:	flrt3 / 558864	ZFINID:	ZDB-GENE-030131-1988	Length:	649	Species:	Danio rerio

Alignment Length:	646	Identity:	145/646 - (22%)
Similarity:	240/646 - (37%)	Gaps:	198/646 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQRNMMIAFV-----GIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPS 60
            |..|.|..||     |:...||:    |....|:||..|:||..  .:.|.:..|..:|..:...
Zfish     1 MASNYMSFFVFFIRAGLLLGLAN----PLMTSASCPSQCRCDGT--FIYCNDRDLTSIPSGIPED 59

  Fly    61 IQRLVIKSNKIKT--IDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISN 123
            ...|.:::|:||:  |.:.::....:..:.|..|:|...|..   ....::|:||..|.|..|::
Zfish    60 ATVLFLQNNRIKSAGIPTDLRRLNGVEKIYLYCNNLDEFPTN---LPLNVKELHLQENNIRTITH 121

  Fly   124 KTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIG--YLDPKAFDGLSQLRILYLD 186
                               :.|.|..|     ||||:|.:|.:.  .::..||...:.||:|:|.
Zfish   122 -------------------ASLAQIPF-----IEELHLDDNSVSAVSIEEGAFRDSNHLRLLFLS 162

  Fly   187 DNALTTVPDPVIFQAMP-SLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRN--ISHDSFL 248
            .|.|:|:|     ..:| ::.||....|.:.||...:.|||..|.||.|.|..|.|  |...:.:
Zfish   163 RNHLSTIP-----SGLPMTIEELRFDDNRISSISEASLQDLINLKRLVLDGNLLNNRGIGEMALV 222

  Fly   249 GLQELRILDLSDNRLDRIPS--VGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALR 311
            .|..|..|.|..|.|...|:  .|.|    ||:|:|..|....:..|||..|:||.||:::|
Zfish   223 NLVNLTELSLVRNSLTSPPANLPGSS----LEKLNLQDNHINHVPPGAFAFLRQLYRLDLSG--- 280

  Fly   312 LKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQT 376
                                                           |.|:||..|:|  :||..
Zfish   281 -----------------------------------------------NNLSSLPMGVF--EDLDN 296

  Fly   377 LD---LSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHAD- 437
            |.   |..||..|:||:.|:.:.| ....|:.:|...:|:.|::::|.:::.|:..:.||:..:
Zfish   297 LTQLLLRNNPWHCNCRMKWVRDWL-RTLPSKVNVRGFMCQGPDKVKGMAIKDLSTELFGCSDTEI 360

  Fly   438 -------------------------------------------PRKQALIGALLVGSAA------ 453
                                                       |..:.:|...:..|:|
Zfish   361 PTTYETSTVSNTLPPSRPQWPSYVTKRPVVKGPDLGRNYRSTTPSSRKIITISVKSSSAETVHIS 425

  Fly   454 -----TITALALVLYRCRH-----KIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPC 508
                 .:|||.|...:..|     .|.|||..|         :..||..|..:.:    ..:..|
Zfish   426 WRVSQPMTALRLSWLKLGHSPAFGSITETIVQG---------ERTEYLLTALEPE----SSYRIC 477

  Fly   509 SLGIHSTFPNTYTAPHHP-------GATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTATMI 562
            .:.:.::  |.|.:...|       |:...|.    |...|.....::.::...:|.|::|
Zfish   478 MVPMETS--NIYLSDETPVCIETETGSLKAYN----PTTTLNREQEKEPYKNSNLPLASII 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	5/19 (26%)
		LRR_8	83..142	CDD:290566	10/58 (17%)
		leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_RI	129..421	CDD:238064	80/301 (27%)
		LRR_8	132..190	CDD:290566	16/59 (27%)
		leucine-rich repeat	132..155	CDD:275380	3/22 (14%)
		leucine-rich repeat	156..179	CDD:275380	8/24 (33%)
		leucine-rich repeat	180..204	CDD:275380	9/24 (38%)
		LRR_8	203..263	CDD:290566	22/62 (35%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	9/24 (38%)
		LRR_8	252..308	CDD:290566	21/57 (37%)
		leucine-rich repeat	253..276	CDD:275380	8/24 (33%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		leucine-rich repeat	301..322	CDD:275380	4/20 (20%)
		LRR_8	325..384	CDD:290566	11/61 (18%)
		leucine-rich repeat	326..350	CDD:275380	0/23 (0%)
		leucine-rich repeat	351..373	CDD:275380	6/21 (29%)
flrt3	NP_001243575.1	LRRNT	31..61	CDD:214470	8/31 (26%)
		leucine-rich repeat	61..84	CDD:275378	5/22 (23%)
		leucine-rich repeat	85..105	CDD:275380	4/22 (18%)
		LRR_RI	104..327	CDD:238064	83/308 (27%)
		leucine-rich repeat	106..129	CDD:275380	8/41 (20%)
		leucine-rich repeat	130..155	CDD:275380	8/24 (33%)
		LRR_8	131..211	CDD:290566	29/84 (35%)
		leucine-rich repeat	156..176	CDD:275380	9/24 (38%)
		leucine-rich repeat	177..200	CDD:275380	8/22 (36%)
		LRR_8	178..237	CDD:290566	21/58 (36%)
		leucine-rich repeat	201..226	CDD:275380	9/24 (38%)
		leucine-rich repeat	227..248	CDD:275380	7/20 (35%)
		LRR_8	247..306	CDD:290566	25/114 (22%)
		leucine-rich repeat	249..272	CDD:275380	9/22 (41%)
		leucine-rich repeat	273..296	CDD:275380	12/74 (16%)
		LRRCT	305..356	CDD:214507	14/51 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	2	1.870