DRSC/TRiP Functional Genomics Resources

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Protein Alignment trn and LRRN3

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001093128.1 Gene:LRRN3 / 54674 HGNCID:17200 Length:708 Species:Homo sapiens


Alignment Length:452 Identity:120/452 - (26%)
Similarity:198/452 - (43%) Gaps:48/452 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 NCPPGCQCD-----------DNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYA 82
            :||..|.|:           .....|.|.:..|...|..|..:.|.|::::|.|..|:.|..|..
Human    28 DCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYSTDFPV 92

  Fly    83 ELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQ 147
            .||.||||.|:|.::.........:|..|:|..||:.::..|....||.:..|.:..|.:|.:..
Human    93 NLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISP 157

  Fly   148 GTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGM 212
            |.|..|..:..|:|..||:..::.|.||.|..|.||.:.:|.:..:.|                |
Human   158 GAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKD----------------M 206

  Fly   213 NTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRL 277
            |         |:.|..|..|.:.|.:|..|..::.:||:.|..:...||||.::|.|.|.|:|.|
Human   207 N---------FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNL 262

  Fly   278 EQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQE 342
            :.|.|.:|....|..|.|..:..||.|.:|....|..:.:.|..:..:|..:..::|..|..:..
Human   263 KFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHP 327

  Fly   343 GALSGLSQLKHVVLKANALTSLAEG-LFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDD 406
            .|...|.:|:.::|.:|||::|..| :....:|:.:.:..||:.|||.:.|::  :...|....:
Human   328 NAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMN--MNKTNIRFME 390

  Fly   407 VSELLCEFPERLRGESLR--HLNPAMMGCTHADPRKQALIGALLVGSAATITALALVLYRCR 466
            ...|.|..|...:|:::|  |....|..|.       .||......|...:.|.:.|.:.||
Human   391 PDSLFCVDPPEFQGQNVRQVHFRDMMEICL-------PLIAPESFPSNLNVEAGSYVSFHCR 445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 6/17 (35%)
LRR_8 83..142 CDD:290566 18/58 (31%)
leucine-rich repeat 84..107 CDD:275380 8/22 (36%)
leucine-rich repeat 108..131 CDD:275380 7/22 (32%)
LRR_RI 129..421 CDD:238064 78/292 (27%)
LRR_8 132..190 CDD:290566 18/57 (32%)
leucine-rich repeat 132..155 CDD:275380 6/22 (27%)
leucine-rich repeat 156..179 CDD:275380 8/22 (36%)
leucine-rich repeat 180..204 CDD:275380 5/23 (22%)
LRR_8 203..263 CDD:290566 14/59 (24%)
leucine-rich repeat 205..228 CDD:275380 4/22 (18%)
leucine-rich repeat 229..252 CDD:275380 7/22 (32%)
LRR_8 252..308 CDD:290566 20/55 (36%)
leucine-rich repeat 253..276 CDD:275380 9/22 (41%)
leucine-rich repeat 277..300 CDD:275380 7/22 (32%)
leucine-rich repeat 301..322 CDD:275380 6/20 (30%)
LRR_8 325..384 CDD:290566 14/59 (24%)
leucine-rich repeat 326..350 CDD:275380 5/23 (22%)
leucine-rich repeat 351..373 CDD:275380 7/22 (32%)
LRRN3NP_001093128.1 LRRNT 28..72 CDD:214470 9/43 (21%)
LRR 1 70..91 6/20 (30%)
leucine-rich repeat 72..93 CDD:275380 7/20 (35%)
LRR <75..355 CDD:227223 86/304 (28%)
LRR 2 93..114 8/20 (40%)
leucine-rich repeat 94..117 CDD:275380 8/22 (36%)
LRR 3 117..138 6/20 (30%)
leucine-rich repeat 118..141 CDD:275380 7/22 (32%)
LRR 4 141..162 5/20 (25%)
leucine-rich repeat 142..165 CDD:275380 6/22 (27%)
LRR 5 165..186 6/20 (30%)
leucine-rich repeat 166..189 CDD:275380 8/22 (36%)
LRR 6 189..210 8/45 (18%)
leucine-rich repeat 190..213 CDD:275380 9/47 (19%)
LRR 7 213..234 5/20 (25%)
leucine-rich repeat 214..237 CDD:275380 7/22 (32%)
LRR 8 237..258 8/20 (40%)
leucine-rich repeat 238..261 CDD:275380 9/22 (41%)
LRR 9 261..282 7/20 (35%)
leucine-rich repeat 262..285 CDD:275380 7/22 (32%)
LRR 10 285..304 5/18 (28%)
leucine-rich repeat 286..310 CDD:275380 6/23 (26%)
LRR 11 310..332 4/21 (19%)
leucine-rich repeat 311..333 CDD:275380 4/21 (19%)
LRR 12 335..358 7/22 (32%)
leucine-rich repeat 336..359 CDD:275380 7/22 (32%)
PCC 341..>442 CDD:188093 27/109 (25%)
Ig 437..513 CDD:325142 3/9 (33%)
fn3 526..593 CDD:306538
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 153 1.000 Inparanoid score I4346
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8524
orthoMCL 1 0.900 - - OOG6_103993
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.960

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