DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Lingo4

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001102659.1	Gene:	Lingo4 / 499668	RGDID:	1562025	Length:	618	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	134/459 - (29%)
Similarity:	201/459 - (43%)	Gaps:	84/459 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTID- 75
            :|..|..:.:.|...:::||..|.|...|..|.|...:||.:|..|....:.|.:..|::..:.
  Rat    38 LWSPLLFLLLLPGGSISSCPTLCDCTSQTRAVLCAHRRLDTVPGGLPLDTEVLDLSGNRLWGLQR 102

  Fly    76 SSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGN 140
            ..:....:|..||||.|.|.|:....|...:.|..:.|..|::..:....|.||||:|:|:||.|
  Rat   103 GMLSRLGQLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIVGPGIFSGLSALTLLDLRLN 167

  Fly   141 QISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSL 205
            ||.....|.|..|..:::|.:|:|.:.::.|.||.||::|..:.|:...|:|||...:.| :|:|
  Rat   168 QIVLFLDGAFGELGSLQQLEVGDNHLVFVAPGAFSGLAKLSTITLERCNLSTVPGLALAQ-LPAL 231

  Fly   206 AELFL--------------GMNTLQSIQADAFQDLKGLTRLELKGASLR-------NISHDSFLG 249
            ..|.|              |:..|:.::...:..|:.|....|.|.:|.       |:|...|..
  Rat   232 VALRLRELDIERLPSGALRGLGQLKELEIHHWPSLEALDPGSLVGLNLSSLAITHCNLSSVPFQA 296

  Fly   250 LQE---LRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALR 311
            |..   |::||||.|.:..||:..||.||||::|.|.......|:..||.||.
  Rat   297 LHHLSFLQVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLT------------ 349

  Fly   312 LKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKD-LQ 375
                   ||.               ||:|.:                |||.:|.|..||..| |.
  Rat   350 -------AFH---------------LLDVAD----------------NALQTLEETAFPSPDKLV 376

  Fly   376 TLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRH----LNPAMMGCTHA 436
            ||.||.|||:||||::||..|   :.......|...|..|:.::|::||.    |.|....|..|
  Rat   377 TLRLSGNPLTCDCRLLWLLRL---RRRLDFGTSPPACAGPQHVQGKNLREFSDILPPGHFTCKPA 438

  Fly   437 DPRK 440
            ..||
  Rat   439 LIRK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/18 (11%)
		LRR_8	83..142	CDD:290566	22/58 (38%)
		leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_RI	129..421	CDD:238064	95/316 (30%)
		LRR_8	132..190	CDD:290566	20/57 (35%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	21/83 (25%)
		leucine-rich repeat	205..228	CDD:275380	6/36 (17%)
		leucine-rich repeat	229..252	CDD:275380	8/29 (28%)
		LRR_8	252..308	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	11/22 (50%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		LRR_8	325..384	CDD:290566	17/59 (29%)
		leucine-rich repeat	326..350	CDD:275380	3/23 (13%)
		leucine-rich repeat	351..373	CDD:275380	7/21 (33%)
Lingo4	NP_001102659.1	leucine-rich repeat	87..110	CDD:275380	2/22 (9%)
		LRR_8	88..145	CDD:290566	14/56 (25%)
		LRR_4	88..126	CDD:289563	10/37 (27%)
		LRR_RI	110..345	CDD:238064	74/235 (31%)
		leucine-rich repeat	111..134	CDD:275380	9/22 (41%)
		LRR_8	134..193	CDD:290566	21/58 (36%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..182	CDD:275380	10/22 (45%)
		LRR_8	182..237	CDD:290566	18/55 (33%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		leucine-rich repeat	207..230	CDD:275380	7/23 (30%)
		leucine-rich repeat	231..254	CDD:275380	4/22 (18%)
		leucine-rich repeat	255..302	CDD:275380	10/46 (22%)
		LRR_8	278..334	CDD:290566	21/55 (38%)
		leucine-rich repeat	303..326	CDD:275380	11/22 (50%)
		LRR_8	326..385	CDD:290566	28/108 (26%)
		leucine-rich repeat	327..348	CDD:275380	6/20 (30%)
		leucine-rich repeat	351..374	CDD:275380	11/53 (21%)
		IG_like	445..526	CDD:214653
		Ig	456..526	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010