DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and vasn

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001005036.1	Gene:	vasn / 448556	XenbaseID:	XB-GENE-941552	Length:	661	Species:	Xenopus tropicalis

Alignment Length:	720	Identity:	165/720 - (22%)
Similarity:	255/720 - (35%)	Gaps:	213/720 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IWCILASIGVEPAAGLANCPPGCQCDDNT-LVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTID 75
            :|.||.:...:...  ..||.||||  || ..|.|...:....|.::.|....|.:..|.|.:|:
Frog     6 VWIILLATAQQMIT--EGCPAGCQC--NTPQTVFCLARKNSNFPRSVPPDTLNLYVFENGISSIE 66

  Fly    76 SSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGN 140
            .|       :|:.|:..||:                .|:||::..:....|..|:.::.|:|..|
Frog    67 ES-------SFIGLNGLHLL----------------DLSHNQLSSLPGGVFRNLANLSNLDLTSN 108

  Fly   141 QISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSL 205
            |::|:...||..|.::|.|.|..|||..:.|:||.|:..|..|.|.:|.|.|   |..| ::|.|
Frog   109 QLTEISADTFQGLSRLERLYLNGNRIRSIHPEAFKGIESLLELKLSNNQLVT---PPAF-SLPHL 169

  Fly   206 AELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVG 270
            ..|.|..|.:..||...| :...:..|.|.|..|:.:..:...||:.|..||||||:||::|. |
Frog   170 LLLDLSYNAIPVIQQGVF-NAGNIESLRLAGLGLKEVPEELLSGLKNLHELDLSDNQLDKVPP-G 232

  Fly   271 LSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNK 335
            |..|.:                                                    ||::.|.
Frog   233 LHGLTK----------------------------------------------------LNIAGNV 245

  Fly   336 MLLEVQEGALSGLSQLKHVVLKANALTSLAEGLF-PWKDLQTLDLSENPLSCDCRVMWLHNLLVA 399
            ...::|...||.|..|:.:.|...:|.:|.:||| ..|.|:.:.|::||.:|.|.:.||...:..
Frog   246 GFSQIQVDDLSNLPALQELDLSGLSLQTLPKGLFRSSKRLRAVSLAQNPFNCVCSLGWLSEWMRV 310

  Fly   400 KNASQDDVSELLCEFPERLRGESLRHLNPAMMGC----------------THADP--RKQALIGA 446
            .........|..|.||.:..|::||.|..:..||                |...|  .|.....|
Frog   311 SGVVLLRPDETRCHFPPKNAGKTLRQLRDSEYGCPAPTTIQMPSTMPPSTTTGPPTTTKHLQTEA 375

  Fly   447 LLVGSAATITALALVLYRCRHKIRE-------------------TIKGGLWGNSALGRKERE--- 489
            ....|..|.|        ..|:.:|                   .:.||.......|:.|.|
Frog   376 PTTASTTTTT--------IPHQEQEEDTQPFQFDFEDTLCPPQTCLNGGSCHLDPTGQLECECPP 432

  Fly   490 -YQKTFCDE----------------------------DYMSRHQHHPCSLGIHSTFPNTYTAPHH 525
             :|.|:|:.                            |..|..|:......|..|..|.|.|...
Frog   433 GFQGTYCETGPVTPAVVTEMYIEQVKIIEVTVSSIRVDLQSYSQNKEKLRAIRLTVRNLYGADRR 497

  Fly   526 PGATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTATMISEKKLNNNKA----LVSQGAIDDSASFV 586
            |      .:..:|                  ||....:.:.|::|.:    |.|||  :......
Frog   498 P------MIYKLP------------------PTLPEYTVRALSSNSSYWVCLGSQG--EGGPEED 536

  Fly   587 LHMKSATMGRDVHQQNPQLNHYTKPQ---------------FLSATATVGDSCYSYADVPMVHGA 636
            |..::.|:| :..:.:||:   |:.|               .|.:.|....:||:.......|..
Frog   537 LCTETHTLG-EPPKHSPQV---TQSQEGNLTLVLVPAVAAGILLSAAVAAAACYARRRKGKGHSV 597

  Fly   637 PLGGP 641
            ..|||
Frog   598 EDGGP 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	5/17 (29%)
		LRR_8	83..142	CDD:290566	12/58 (21%)
		leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		leucine-rich repeat	108..131	CDD:275380	5/22 (23%)
		LRR_RI	129..421	CDD:238064	81/292 (28%)
		LRR_8	132..190	CDD:290566	22/57 (39%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	10/22 (45%)
		leucine-rich repeat	180..204	CDD:275380	8/23 (35%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..308	CDD:290566	13/55 (24%)
		leucine-rich repeat	253..276	CDD:275380	13/22 (59%)
		leucine-rich repeat	277..300	CDD:275380	0/22 (0%)
		leucine-rich repeat	301..322	CDD:275380	0/20 (0%)
		LRR_8	325..384	CDD:290566	18/59 (31%)
		leucine-rich repeat	326..350	CDD:275380	7/23 (30%)
		leucine-rich repeat	351..373	CDD:275380	7/22 (32%)
vasn	NP_001005036.1	LRRNT	21..52	CDD:214470	12/32 (38%)
		leucine-rich repeat	52..75	CDD:275380	7/29 (24%)
		LRR 1	52..72		6/26 (23%)
		LRR	<60..>276	CDD:227223	77/296 (26%)
		LRR 2	75..96		6/36 (17%)
		leucine-rich repeat	76..99	CDD:275380	7/38 (18%)
		LRR_8	99..158	CDD:338972	22/58 (38%)
		LRR 3	99..120		7/20 (35%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		LRR 4	123..144		9/20 (45%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR 5	147..168		8/24 (33%)
		leucine-rich repeat	148..169	CDD:275380	9/24 (38%)
		LRR 6	169..189		7/20 (35%)
		leucine-rich repeat	170..191	CDD:275380	6/21 (29%)
		LRR 7	191..212		4/20 (20%)
		leucine-rich repeat	192..215	CDD:275380	6/22 (27%)
		LRR 8	215..237		12/22 (55%)
		leucine-rich repeat	216..235	CDD:275380	12/19 (63%)
		leucine-rich repeat	236..260	CDD:275380	8/75 (11%)
		LRR 9	238..258		6/71 (8%)
		LRR 10	259..281		7/21 (33%)
		leucine-rich repeat	261..281	CDD:275380	7/19 (37%)
		PCC	265..>344	CDD:188093	23/78 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..395		9/54 (17%)
		EGF	407..438	CDD:333761	6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	591..661		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010