DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and lingo1b

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001004576.1	Gene:	lingo1b / 447837	ZFINID:	ZDB-GENE-040912-136	Length:	622	Species:	Danio rerio

Alignment Length:	606	Identity:	146/606 - (24%)
Similarity:	231/606 - (38%)	Gaps:	116/606 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VGIW--CILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIK 72
            |..|  .::..:|...:.....||..|:|......|.|...:|..||..:
Zfish    22 VACWQPILILMLGTVLSGSATGCPSRCECSAQERSVVCHRRKLITLPEGI--------------- 71

  Fly    73 TIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNL 137
            .||:.:        ||||.|.|..|....|....:|:::.||.|.|..|....|..|..:..|.|
Zfish    72 PIDTRL--------LDLSKNRLKAINPEEFLNYPQLEDLQLNENIISVIEPGAFSNLLGLRTLGL 128

  Fly   138 RGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAM 202
            |.|.:..:..|.||.|..:..|::.||:|..|....|..|..|:.|.:.||.|..:.... |..:
Zfish   129 RNNNLKLIQLGVFTGLSNLTRLDISENKIVILLDYMFQELYNLKELEVGDNDLVFISHRA-FHGL 192

  Fly   203 PSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILD---------- 257
            .||.:|.:....|.|:..:||..|..|..|:|:..::..|...||..|..|:||:
Zfish   193 SSLEQLTMERCNLTSVPTEAFSHLHNLLTLKLRHLNVNVIRDFSFRRLYRLKILEIANWPLLESL 257

  Fly   258 --------------LSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNG 308
                          :::..|..:|.|.:..||.|...:|..|..||:.......|.:|:...:.|
Zfish   258 TAKSLHGLNITTLSITNCNLTAVPYVAIQHLVYLRFFNLSFNPIEVVEGNKMHNLLRLQAFHLVG 322

  Fly   309 ALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLF-PWK 372
            .                          .|:.::..:..||:.|:.:.:.:|:|::|.|..| ...
Zfish   323 G--------------------------RLVSIEPYSFKGLNYLRVLNVSSNSLSTLEESAFHSVG 361

  Fly   373 DLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRH----LNPAMMGC 433
            :|:||.|.:|||:||||::|:.......|.::...|   ||.||.|:|:..:.    |.|....|
Zfish   362 NLETLALHDNPLACDCRLLWVFRRRWRLNFNRQQPS---CETPEFLQGKEFKDFPDVLPPNYFTC 423

  Fly   434 THADPRKQALIGALLVGSAATI--------TALALVLYRCRHKIRETIKG-GLWGNSALGRKERE 489
            ..:..|....|.. .|....|:        ....:::::...|...|.|. |....|..|..|..
Zfish   424 QKSKIRDHKAIHR-FVDEGTTVQFPCQADGDPTPMIMWQSPKKQFITTKSIGRLSVSLDGTLEVR 487

  Fly   490 YQKTFCDEDYM----------SRHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGMCPMP----VN 540
            |.:...:..|.          :|..|    |.:||..||.   ||.|..|..: :...|    .|
Zfish   488 YAQIQDNGTYTCFAVNAGGNDTRLAH----LHVHSYSPNW---PHQPNKTFAF-ILNQPSDNSAN 544

  Fly   541 DLGAIDPQQKFQQLVVPTATM 561
            ..||:||.....:.::...||
Zfish   545 GTGAMDPFPFDMKTLIIATTM 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/17 (12%)
		LRR_8	83..142	CDD:290566	20/58 (34%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_RI	129..421	CDD:238064	81/316 (26%)
		LRR_8	132..190	CDD:290566	19/57 (33%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	6/23 (26%)
		LRR_8	203..263	CDD:290566	18/83 (22%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	15/79 (19%)
		leucine-rich repeat	253..276	CDD:275380	7/46 (15%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		LRR_8	325..384	CDD:290566	14/59 (24%)
		leucine-rich repeat	326..350	CDD:275380	3/23 (13%)
		leucine-rich repeat	351..373	CDD:275380	6/22 (27%)
lingo1b	NP_001004576.1	LRRNT	43..77	CDD:214470	11/48 (23%)
		LRR 1	74..95		9/28 (32%)
		leucine-rich repeat	75..98	CDD:275380	8/30 (27%)
		LRR_8	76..133	CDD:290566	20/64 (31%)
		LRR_RI	78..>315	CDD:238064	66/237 (28%)
		LRR 2	98..119		7/20 (35%)
		leucine-rich repeat	99..146	CDD:275380	16/46 (35%)
		LRR 3	122..143		6/20 (30%)
		LRR_8	130..181	CDD:290566	16/50 (32%)
		LRR 4	146..167		6/20 (30%)
		leucine-rich repeat	147..170	CDD:275380	7/22 (32%)
		LRR_8	170..226	CDD:290566	17/56 (30%)
		LRR 5	170..191		6/21 (29%)
		leucine-rich repeat	171..194	CDD:275380	6/23 (26%)
		LRR 6	194..215		7/20 (35%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		LRR 7	218..239		6/20 (30%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		leucine-rich repeat	243..290	CDD:275380	7/46 (15%)
		LRR_8	266..325	CDD:290566	13/84 (15%)
		LRR 8	266..287		3/20 (15%)
		LRR 9	290..311		5/20 (25%)
		leucine-rich repeat	291..338	CDD:275380	11/72 (15%)
		LRR_8	314..373	CDD:290566	16/84 (19%)
		LRR 10	314..335		3/46 (7%)
		LRR 11	338..359		6/20 (30%)
		leucine-rich repeat	339..362	CDD:275380	6/22 (27%)
		TPKR_C2	371..424	CDD:301599	18/55 (33%)
		IG_like	438..516	CDD:214653	14/81 (17%)
		Ig	441..516	CDD:299845	13/78 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010