DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Tollo

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	113/381 - (29%)
Similarity:	183/381 - (48%)	Gaps:	47/381 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CGE--GQLDV-------LPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTF--------LDLSSN 92
            ||.  ..||:       ||.|:..::.||    ..:....:|:.|.|:..|        :|||:|
  Fly   208 CGSTLQSLDLSANKMVSLPTAMLSALGRL----THLNMAKNSMSFLADRAFEGLLSLRVVDLSAN 268

  Fly    93 HLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISE--LHQGTFTPLLK 155
            .|.::|...||..|:|||::|.:|.|..::...|..|:.:.||:|..|:::.  ::..||..|.:
  Fly   269 RLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKR 333

  Fly   156 IEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQA 220
            :..|:|..|:|..|:...|..|:.|:||.|:||.:..:|.. ||..:.:|..|.|..|.:..|:.
  Fly   334 LMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGG-IFADLTNLHTLILSRNRISVIEQ 397

  Fly   221 DAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQN 285
            ...|.||.|..|.|....:..:...|.:...:|:.|.|:||:|..:|. .|:.:..|:.|.:|:|
  Fly   398 RTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPE-ALAHVQLLKTLDVGEN 461

  Fly   286 DFEVISEGAFMGLKQL--KRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGL 348
            ....|...:...|:.|  .|:..|....::|   |.|....:|:.||||.|| |..::.|:|...
  Fly   462 MISQIENTSITQLESLYGLRMTENSLTHIRR---GVFDRMSSLQILNLSQNK-LKSIEAGSLQRN 522

  Fly   349 SQLKHVVLKANALTSLAEGLFP------WKD-----LQTLDLSENPLSCDCRVMWL 393
            |||:.:.|..|.|.|:| |||.      |.:     |:..|.|..|:.    :.||
  Fly   523 SQLQAIRLDGNQLKSIA-GLFTELPNLVWLNISGNRLEKFDYSHIPIG----LQWL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	3/17 (18%)
		LRR_8	83..142	CDD:290566	22/66 (33%)
		leucine-rich repeat	84..107	CDD:275380	9/30 (30%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_RI	129..421	CDD:238064	84/280 (30%)
		LRR_8	132..190	CDD:290566	20/59 (34%)
		leucine-rich repeat	132..155	CDD:275380	7/24 (29%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	9/23 (39%)
		LRR_8	203..263	CDD:290566	17/59 (29%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	4/22 (18%)
		LRR_8	252..308	CDD:290566	16/57 (28%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	6/22 (27%)
		LRR_8	325..384	CDD:290566	25/69 (36%)
		leucine-rich repeat	326..350	CDD:275380	10/23 (43%)
		leucine-rich repeat	351..373	CDD:275380	10/27 (37%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	21/76 (28%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	4/13 (31%)
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	111/379 (29%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	236..259	CDD:275380	5/26 (19%)
		leucine-rich repeat	260..283	CDD:275380	8/22 (36%)
		LRR_RI	276..558	CDD:238064	88/288 (31%)
		leucine-rich repeat	284..307	CDD:275380	8/22 (36%)
		leucine-rich repeat	308..333	CDD:275380	7/24 (29%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	9/23 (39%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		leucine-rich repeat	430..452	CDD:275380	8/22 (36%)
		leucine-rich repeat	453..500	CDD:275380	12/49 (24%)
		leucine-rich repeat	501..521	CDD:275380	10/20 (50%)
		leucine-rich repeat	525..547	CDD:275380	9/22 (41%)
		leucine-rich repeat	548..573	CDD:275380	5/28 (18%)
		leucine-rich repeat	604..640	CDD:275380
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840