DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and 2mit

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	476	Identity:	115/476 - (24%)
Similarity:	191/476 - (40%)	Gaps:	83/476 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IAFVGIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQL---DVLPIALNPSIQRLVIKS 68
            :|.:..|..|..:.|  ||.|.:.|     ..:.|..:..|.||   ||..::.. ||.|::...
  Fly    13 LALLLAWTWLTRLVV--AAHLVDIP-----TSSRLAAEREEQQLSRQDVGRLSYQ-SIHRMLRDE 69

  Fly    69 NKIKTIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVT 133
            |:..:....:::..:....:|..|          |...||...|.:.........:.......:|
  Fly    70 NEPDSFRGELRYQQKRHKRELELN----------APANKLNLTHRDLRTFNSTGGQWKGDFQVIT 124

  Fly   134 VLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLD--DNALTTVPDP 196
            .::|..||:..|....|.   ::.:|:||.|.:..:.....|....|..:.||  .|..:.:...
  Fly   125 AMDLSSNQLESLSLDNFN---QLRQLDLGNNSLEVIPLSLADTNMSLPFVTLDLSCNKFSQISTS 186

  Fly   197 VIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDN 261
            ...|.:|.|..|.|..|.|.:|..::|.:|..|..|.|...::.:|.:::||.|..|:.||||.|
  Fly   187 FFAQRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHN 251

  Fly   262 RLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNG-------ALRLKRVMTGA 319
            ||.......|..:..|..||:..|....::...|:....||.|:.:|       |...:.|.|..
  Fly   252 RLSGSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALAQSVRTLK 316

  Fly   320 FSDN-------GN------LEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFP- 370
            .|||       |:      |:||:||.:: :.:|::.||..|..|:.:.|..|.|..:...|.|
  Fly   317 LSDNWLKAINCGDMDSYPLLQYLDLSHSR-IAQVEDDALGRLELLESLFLDRNLLMRVPSSLPPS 380

  Fly   371 ---------------------WKDLQTLDLSENPLSCDCRVMWLHNLLVAK-------NASQDDV 407
                                 ..:|||||||.|      |:::|..|.:.|       ::..:.|
  Fly   381 LEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNN------RLIFLPPLSLPKLLTLNLESSGVESV 439

  Fly   408 SELLCEFPERLRGESLRHLNP 428
            |:.:.....:|| :.|...||
  Fly   440 SQSIVHTLPQLR-DLLLEDNP 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/17 (12%)
		LRR_8	83..142	CDD:290566	9/58 (16%)
		leucine-rich repeat	84..107	CDD:275380	3/22 (14%)
		leucine-rich repeat	108..131	CDD:275380	2/22 (9%)
		LRR_RI	129..421	CDD:238064	88/342 (26%)
		LRR_8	132..190	CDD:290566	15/59 (25%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		leucine-rich repeat	156..179	CDD:275380	5/22 (23%)
		leucine-rich repeat	180..204	CDD:275380	5/25 (20%)
		LRR_8	203..263	CDD:290566	22/59 (37%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	17/55 (31%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..322	CDD:275380	7/27 (26%)
		LRR_8	325..384	CDD:290566	23/86 (27%)
		leucine-rich repeat	326..350	CDD:275380	9/23 (39%)
		leucine-rich repeat	351..373	CDD:275380	6/43 (14%)
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	64/234 (27%)
		leucine-rich repeat	124..143	CDD:275380	6/21 (29%)
		leucine-rich repeat	144..167	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..194	CDD:275380	4/21 (19%)
		LRR_8	193..253	CDD:290566	22/59 (37%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		LRR_8	241..301	CDD:290566	18/59 (31%)
		leucine-rich repeat	243..311	CDD:275380	19/67 (28%)
		leucine-rich repeat	312..335	CDD:275380	6/22 (27%)
		LRR_8	334..415	CDD:290566	23/87 (26%)
		leucine-rich repeat	336..359	CDD:275380	9/23 (39%)
		leucine-rich repeat	360..380	CDD:275380	5/19 (26%)
		LRR_8	379..460	CDD:290566	20/88 (23%)
		LRR_4	379..>415	CDD:289563	9/41 (22%)
		leucine-rich repeat	381..404	CDD:275380	0/22 (0%)
		leucine-rich repeat	405..449	CDD:275380	14/49 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472911
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840