DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and CD180

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_005573.2 Gene:CD180 / 4064 HGNCID:6726 Length:661 Species:Homo sapiens


Alignment Length:624 Identity:136/624 - (21%)
Similarity:203/624 - (32%) Gaps:228/624 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 WCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTI-DS 76
            |.:|.|.|.:.   :.:....|...:......|....|..:|..|..:.:.|....|.:.|| :.
Human    10 WVVLFSAGCKV---ITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNR 71

  Fly    77 SIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQ 141
            :......||||||:...:..|.:.||....:|..:.|..|.:..::..:..|..::..|.|....
Human    72 TFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTG 136

  Fly   142 ISELHQGTFTP---LLKIEELNLGENRIGYLD-PKAFDGLSQLRILYLDDNALTTVP-------- 194
            ||.|.   |.|   |..:|.|.||.|.|..:. ||.|.. ..|::|...:||:..:.        
Human   137 ISNLE---FIPVHNLENLESLYLGSNHISSIKFPKDFPA-RNLKVLDFQNNAIHYISREDMRSLE 197

  Fly   195 ----------------------DPVIFQAM-----PSLAELFLGM--NTLQSIQADAFQD----- 225
                                  |..|||::     |:|:.:|.|:  :|.||:....|:|     
Human   198 QAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDED 262

  Fly   226 -----LKGLTRLELKGASLR-----NISHDSFLGLQELRILDLSDNRLDRIPS------------ 268
                 ||||..:.::..:|:     :||..:|....:|:.|||:...|..:||            
Human   263 ISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLV 327

  Fly   269 -----------------------------------VG-LSKLVRLEQLSLGQNDFEV-------- 289
                                               || |.||..|:.|.|..||.|.        
Human   328 LSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQL 392

  Fly   290 ------------------ISEGAFMGLKQLK-------RLEVNGA------LRLKRV--MTGAFS 321
                              :...||....||:       ||.:|..      |...:|  :|..|.
Human   393 KNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFL 457

  Fly   322 DNGN---------LEYLNLSSNKM--------------------------LLEVQEGALSGLSQL 351
            |..|         |.:|||..|..                          ||.:.:.|...|.::
Human   458 DTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKM 522

  Fly   352 KHVVLKANALTS-----------------------LAEGLFPWKDLQ-TLDLSENPLSCDCR--- 389
            .||.|..|:||.                       ::..|.|....| |::||.|||.|.|.   
Human   523 SHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIH 587

  Fly   390 -VMW----LHNLLVAKNASQDDVSELLCEFPERLRGESL 423
             :.|    ||.|        :...|..|..|..|||..|
Human   588 FLTWYKENLHKL--------EGSEETTCANPPSLRGVKL 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 4/18 (22%)
LRR_8 83..142 CDD:290566 15/58 (26%)
leucine-rich repeat 84..107 CDD:275380 9/22 (41%)
leucine-rich repeat 108..131 CDD:275380 4/22 (18%)
LRR_RI 129..421 CDD:238064 108/503 (21%)
LRR_8 132..190 CDD:290566 20/61 (33%)
leucine-rich repeat 132..155 CDD:275380 8/25 (32%)
leucine-rich repeat 156..179 CDD:275380 9/23 (39%)
leucine-rich repeat 180..204 CDD:275380 8/58 (14%)
LRR_8 203..263 CDD:290566 21/76 (28%)
leucine-rich repeat 205..228 CDD:275380 9/34 (26%)
leucine-rich repeat 229..252 CDD:275380 5/27 (19%)
LRR_8 252..308 CDD:290566 24/136 (18%)
leucine-rich repeat 253..276 CDD:275380 12/70 (17%)
leucine-rich repeat 277..300 CDD:275380 8/48 (17%)
leucine-rich repeat 301..322 CDD:275380 8/35 (23%)
LRR_8 325..384 CDD:290566 23/117 (20%)
leucine-rich repeat 326..350 CDD:275380 9/49 (18%)
leucine-rich repeat 351..373 CDD:275380 8/44 (18%)
CD180NP_005573.2 leucine-rich repeat 38..57 CDD:275380 4/18 (22%)
LRR 1 54..75 4/20 (20%)
leucine-rich repeat 58..78 CDD:275380 4/19 (21%)
LRR 2 78..99 9/20 (45%)
leucine-rich repeat 79..102 CDD:275380 9/22 (41%)
LRR_8 102..161 CDD:290566 17/61 (28%)
LRR 3 102..123 3/20 (15%)
leucine-rich repeat 103..126 CDD:275380 4/22 (18%)
LRR 4 126..147 7/23 (30%)
leucine-rich repeat 127..150 CDD:275380 8/25 (32%)
LRR 5 150..171 8/20 (40%)
leucine-rich repeat 151..174 CDD:275380 9/23 (39%)
LRR 6 174..195 4/20 (20%)
leucine-rich repeat 175..195 CDD:275380 4/19 (21%)
leucine-rich repeat 196..234 CDD:275380 4/37 (11%)
LRR 7 201..221 0/19 (0%)
leucine-rich repeat 235..275 CDD:275380 12/39 (31%)
LRR 8 275..296 4/20 (20%)
leucine-rich repeat 276..299 CDD:275380 4/22 (18%)
LRR 9 299..320 7/20 (35%)
leucine-rich repeat 300..322 CDD:275380 7/21 (33%)
LRR 10 322..343 0/20 (0%)
LRR_8 323..382 CDD:290566 9/58 (16%)
leucine-rich repeat 323..371 CDD:275380 5/47 (11%)
LRR_RI 327..541 CDD:238064 39/213 (18%)
LRR 11 346..366 2/19 (11%)
LRR_8 371..432 CDD:290566 10/60 (17%)
LRR 12 371..391 6/19 (32%)
leucine-rich repeat 372..397 CDD:275380 6/24 (25%)
LRR 13 397..418 2/20 (10%)
leucine-rich repeat 398..421 CDD:275380 2/22 (9%)
LRR_8 420..481 CDD:290566 16/60 (27%)
LRR 14 421..442 5/20 (25%)
leucine-rich repeat 422..446 CDD:275380 5/23 (22%)
LRR 15 446..466 5/19 (26%)
leucine-rich repeat 447..470 CDD:275380 5/22 (23%)
LRR 16 470..493 5/22 (23%)
leucine-rich repeat 471..497 CDD:275380 5/25 (20%)
LRR_8 497..555 CDD:290566 10/57 (18%)
LRR 17 497..518 3/20 (15%)
leucine-rich repeat 498..521 CDD:275380 4/22 (18%)
LRR 18 521..544 6/22 (27%)
leucine-rich repeat 522..543 CDD:275380 6/20 (30%)
LRR 19 546..564 1/17 (6%)
TPKR_C2 577..626 CDD:301599 16/50 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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