DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and Toll-6

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster

Alignment Length:	394	Identity:	120/394 - (30%)
Similarity:	184/394 - (46%)	Gaps:	37/394 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQR---LVIKSNKIKTI-DSSIQFYA 82
            |.|...::....|..|...|.|  ......|||.....:::|   |.:.:|.|..| |.::....
  Fly   263 ESAKKSSSSSTSCSLDLEYLDV--SHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLK 325

  Fly    83 ELTFLDLSSNHLMTIPQRTFAYQKK-LQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISE-- 144
            .|..|:||||.::.:|...||.|.| :|||:|.:|.|..::.:.|..|..:..|:|..|||:.
  Fly   326 NLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTW 390

  Fly   145 LHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELF 209
            :.:.||..|:::..|||..|::..|:|:.|..|..|:||.|..|.|..:.... |..|.:|..|.
  Fly   391 IDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADT-FAPMNNLHTLL 454

  Fly   210 LGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKL 274
            |..|.|:.:.|.|...|..|:.|.|...:|..:..|:|.....|:.|:|:.|:|..:| :.|..:
  Fly   455 LSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVP-LALRNM 518

  Fly   275 VRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLE 339
            ..|..:.||:|...|:.:.||.||..|..|.:.|.. |:.:....|.|..||:.|||:.|::.:
  Fly   519 RHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNY-LENITMHTFRDLPNLQILNLARNRIAV- 581

  Fly   340 VQEGALSGLSQLKHVVLKANALTSLAEGLFP------W-----------------KDLQTLDLSE 381
            |:.||....|.::.|.|..|.|..: .|||.      |                 ..||.|||.:
  Fly   582 VEPGAFEMTSSIQAVRLDGNELNDI-NGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHK 645

  Fly   382 NPLS 385
            |.||
  Fly   646 NRLS 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	6/21 (29%)
		LRR_8	83..142	CDD:290566	22/59 (37%)
		leucine-rich repeat	84..107	CDD:275380	10/22 (45%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_RI	129..421	CDD:238064	87/282 (31%)
		LRR_8	132..190	CDD:290566	21/59 (36%)
		leucine-rich repeat	132..155	CDD:275380	8/24 (33%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	8/23 (35%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..308	CDD:290566	18/55 (33%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		leucine-rich repeat	301..322	CDD:275380	5/20 (25%)
		LRR_8	325..384	CDD:290566	24/81 (30%)
		leucine-rich repeat	326..350	CDD:275380	8/23 (35%)
		leucine-rich repeat	351..373	CDD:275380	8/44 (18%)
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	3/14 (21%)
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	61/192 (32%)
		leucine-rich repeat	279..302	CDD:275380	5/24 (21%)
		LRR_8	301..386	CDD:290566	28/84 (33%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	10/22 (45%)
		LRR	350..729	CDD:227223	95/305 (31%)
		leucine-rich repeat	352..375	CDD:275380	8/22 (36%)
		leucine-rich repeat	376..401	CDD:275380	8/24 (33%)
		LRR_RI	<401..626	CDD:238064	70/229 (31%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	8/23 (35%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	6/22 (27%)
		leucine-rich repeat	498..518	CDD:275380	7/20 (35%)
		leucine-rich repeat	521..544	CDD:275380	9/22 (41%)
		leucine-rich repeat	545..566	CDD:275380	5/21 (24%)
		leucine-rich repeat	569..592	CDD:275380	8/23 (35%)
		leucine-rich repeat	593..615	CDD:275380	7/22 (32%)
		leucine-rich repeat	616..637	CDD:275380	1/20 (5%)
		leucine-rich repeat	638..662	CDD:275380	8/12 (67%)
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453591
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840